Evaluation of Typical Antipsychotic Augmentation with Citalopram in Reduction of Negative Symptoms in Inpatient Schizophrenia in Ahvaz Golestan Hospital
Background and Objective: The aim of this study was to evaluate the efficacy of citalopram added to typical antipsychotic for the treatment of negative symptoms of inpatients with schizophrenia disorder in Ahvaz Golestan hospital. Subjects and Methods: Forty inpatients suffering from schizophre...
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Ahvaz Jundishapur University of Medical Sciences
2012-09-01
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| Series: | Majalah-i ̒ilmī pizishkī-i jundī/shapūr |
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| Online Access: | http://journals.ajums.ac.ir/components4.php?rQV===AfABDQ6QnchR3cfZGfABDNApDZJRnblJXYw9lZ8B0M4MDQ6QWStVGdp9lZ8BEOApDZJxWY0J3bQxWYuJXdvp2XmxHQyATNApDZJ52bpR3Yh9lZ |
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| author | Masome Nazari Nasab Nilofar Khajeddin Abdol Amin Shanesaz Abbas Pezeshki |
| author_facet | Masome Nazari Nasab Nilofar Khajeddin Abdol Amin Shanesaz Abbas Pezeshki |
| author_sort | Masome Nazari Nasab |
| collection | DOAJ |
| description | Background and Objective: The aim of this study was to evaluate the efficacy of citalopram added to typical antipsychotic for the treatment of negative symptoms of inpatients with schizophrenia disorder in Ahvaz Golestan hospital. Subjects and Methods: Forty inpatients suffering from schizophrenia disorder (DSM-IV-TR) were recruited for a randomized double blind clinical trial. Depression was ruled out by Hamilton Depression Questionnaire. They were randomly assigned to either citalopram (20 mg for first week and 40 mg for next weeks) or placebo added on while the typical antipsychotic was continued. The efficacy of drugs was assessed weekly with PANSS scale during 6 weeks. Results: Mean age was 37/22 years and 60% (n=24) were male. Citalopram did not improve negative symptoms in schizophrenia patients compared to placebo. Citalopram improved general psychopathology symptoms and total PANSS. Conclusion: Citalopram improved general psychopathology symptoms and total PANSS. Adding citalopram on typical antipsychotic treatment did not improve negative symptoms in patients with schizophrenia disorder. |
| format | Article |
| id | doaj-art-6ac4123754bc49eeae85777585a05d4c |
| institution | Kabale University |
| issn | 2252-052X 2252-0619 |
| language | fas |
| publishDate | 2012-09-01 |
| publisher | Ahvaz Jundishapur University of Medical Sciences |
| record_format | Article |
| series | Majalah-i ̒ilmī pizishkī-i jundī/shapūr |
| spelling | doaj-art-6ac4123754bc49eeae85777585a05d4c2025-08-20T03:56:23ZfasAhvaz Jundishapur University of Medical SciencesMajalah-i ̒ilmī pizishkī-i jundī/shapūr2252-052X2252-06192012-09-01114439448Evaluation of Typical Antipsychotic Augmentation with Citalopram in Reduction of Negative Symptoms in Inpatient Schizophrenia in Ahvaz Golestan HospitalMasome Nazari NasabNilofar KhajeddinAbdol Amin Shanesaz Abbas PezeshkiBackground and Objective: The aim of this study was to evaluate the efficacy of citalopram added to typical antipsychotic for the treatment of negative symptoms of inpatients with schizophrenia disorder in Ahvaz Golestan hospital. Subjects and Methods: Forty inpatients suffering from schizophrenia disorder (DSM-IV-TR) were recruited for a randomized double blind clinical trial. Depression was ruled out by Hamilton Depression Questionnaire. They were randomly assigned to either citalopram (20 mg for first week and 40 mg for next weeks) or placebo added on while the typical antipsychotic was continued. The efficacy of drugs was assessed weekly with PANSS scale during 6 weeks. Results: Mean age was 37/22 years and 60% (n=24) were male. Citalopram did not improve negative symptoms in schizophrenia patients compared to placebo. Citalopram improved general psychopathology symptoms and total PANSS. Conclusion: Citalopram improved general psychopathology symptoms and total PANSS. Adding citalopram on typical antipsychotic treatment did not improve negative symptoms in patients with schizophrenia disorder.http://journals.ajums.ac.ir/components4.php?rQV===AfABDQ6QnchR3cfZGfABDNApDZJRnblJXYw9lZ8B0M4MDQ6QWStVGdp9lZ8BEOApDZJxWY0J3bQxWYuJXdvp2XmxHQyATNApDZJ52bpR3Yh9lZSchizophreniaNegative symptomsCitalopram. |
| spellingShingle | Masome Nazari Nasab Nilofar Khajeddin Abdol Amin Shanesaz Abbas Pezeshki Evaluation of Typical Antipsychotic Augmentation with Citalopram in Reduction of Negative Symptoms in Inpatient Schizophrenia in Ahvaz Golestan Hospital Majalah-i ̒ilmī pizishkī-i jundī/shapūr Schizophrenia Negative symptoms Citalopram. |
| title | Evaluation of Typical Antipsychotic Augmentation with Citalopram in Reduction of Negative Symptoms in Inpatient Schizophrenia in Ahvaz Golestan Hospital |
| title_full | Evaluation of Typical Antipsychotic Augmentation with Citalopram in Reduction of Negative Symptoms in Inpatient Schizophrenia in Ahvaz Golestan Hospital |
| title_fullStr | Evaluation of Typical Antipsychotic Augmentation with Citalopram in Reduction of Negative Symptoms in Inpatient Schizophrenia in Ahvaz Golestan Hospital |
| title_full_unstemmed | Evaluation of Typical Antipsychotic Augmentation with Citalopram in Reduction of Negative Symptoms in Inpatient Schizophrenia in Ahvaz Golestan Hospital |
| title_short | Evaluation of Typical Antipsychotic Augmentation with Citalopram in Reduction of Negative Symptoms in Inpatient Schizophrenia in Ahvaz Golestan Hospital |
| title_sort | evaluation of typical antipsychotic augmentation with citalopram in reduction of negative symptoms in inpatient schizophrenia in ahvaz golestan hospital |
| topic | Schizophrenia Negative symptoms Citalopram. |
| url | http://journals.ajums.ac.ir/components4.php?rQV===AfABDQ6QnchR3cfZGfABDNApDZJRnblJXYw9lZ8B0M4MDQ6QWStVGdp9lZ8BEOApDZJxWY0J3bQxWYuJXdvp2XmxHQyATNApDZJ52bpR3Yh9lZ |
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