Serum Vitamin D Level in Pediatric Alopecia Areata
Background: Alopecia areata (AA) is a common, autoimmune, nonscarring hair loss which displays a wide clinical spectrum from localized to generalized variants. It may have a long, relapsing, and unpredictable course. Vitamin D receptors are expressed in the hair follicles. Vitamin D functions as a m...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Paediatric Dermatology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpd.ijpd_53_23 |
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| author | Sneha Sonker Vibhu Mendiratta Ekta Debnath |
| author_facet | Sneha Sonker Vibhu Mendiratta Ekta Debnath |
| author_sort | Sneha Sonker |
| collection | DOAJ |
| description | Background:
Alopecia areata (AA) is a common, autoimmune, nonscarring hair loss which displays a wide clinical spectrum from localized to generalized variants. It may have a long, relapsing, and unpredictable course. Vitamin D receptors are expressed in the hair follicles. Vitamin D functions as a modulator of immune functions of T lymphocytes and B lymphocytes. Deficiency of Vitamin D may be associated with increased risk of AA in children.
Objectives:
The objectives of this study were to compare serum Vitamin D levels in pediatric AA with age- and sex-matched controls and to correlate it with severity, duration, pattern of AA, and nail changes.
Materials and Methods:
This was a hospital-based case–control study of 40 cases of AA aged <18 years along with 30 age- and sex-matched healthy controls. All subjects underwent complete evaluation and laboratory investigations including serum Vitamin D.
Results:
The mean serum Vitamin D was 39.98 ± 18.06 (nmol/L) in cases and 32.26 ± 12.22 (nmol/L) in controls. There was no statistically significant difference (P = 0.080) in Vitamin D levels between the cases and controls. No statistically significant correlation was found between Vitamin D levels and severity, duration of AA, pattern of AA, and nail changes.
Conclusion:
Role of Vitamin D in AA could not be substantiated in our study. There was no correlation between duration, severity, AA pattern, nail changes, and Vitamin D level. Small sample size was a limitation. Further studies with bigger sample size are needed as the prevalence of Vitamin D deficiency is high in India. |
| format | Article |
| id | doaj-art-6abae50afe144a1b80d43f2da805f3f2 |
| institution | OA Journals |
| issn | 2319-7250 2319-7269 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Paediatric Dermatology |
| spelling | doaj-art-6abae50afe144a1b80d43f2da805f3f22025-08-20T02:26:36ZengWolters Kluwer Medknow PublicationsIndian Journal of Paediatric Dermatology2319-72502319-72692025-01-01261162010.4103/ijpd.ijpd_53_23Serum Vitamin D Level in Pediatric Alopecia AreataSneha SonkerVibhu MendirattaEkta DebnathBackground: Alopecia areata (AA) is a common, autoimmune, nonscarring hair loss which displays a wide clinical spectrum from localized to generalized variants. It may have a long, relapsing, and unpredictable course. Vitamin D receptors are expressed in the hair follicles. Vitamin D functions as a modulator of immune functions of T lymphocytes and B lymphocytes. Deficiency of Vitamin D may be associated with increased risk of AA in children. Objectives: The objectives of this study were to compare serum Vitamin D levels in pediatric AA with age- and sex-matched controls and to correlate it with severity, duration, pattern of AA, and nail changes. Materials and Methods: This was a hospital-based case–control study of 40 cases of AA aged <18 years along with 30 age- and sex-matched healthy controls. All subjects underwent complete evaluation and laboratory investigations including serum Vitamin D. Results: The mean serum Vitamin D was 39.98 ± 18.06 (nmol/L) in cases and 32.26 ± 12.22 (nmol/L) in controls. There was no statistically significant difference (P = 0.080) in Vitamin D levels between the cases and controls. No statistically significant correlation was found between Vitamin D levels and severity, duration of AA, pattern of AA, and nail changes. Conclusion: Role of Vitamin D in AA could not be substantiated in our study. There was no correlation between duration, severity, AA pattern, nail changes, and Vitamin D level. Small sample size was a limitation. Further studies with bigger sample size are needed as the prevalence of Vitamin D deficiency is high in India.https://journals.lww.com/10.4103/ijpd.ijpd_53_23alopecia areataautoimmune diseasespediatricseverity of alopecia tool scorevitamin d |
| spellingShingle | Sneha Sonker Vibhu Mendiratta Ekta Debnath Serum Vitamin D Level in Pediatric Alopecia Areata Indian Journal of Paediatric Dermatology alopecia areata autoimmune diseases pediatric severity of alopecia tool score vitamin d |
| title | Serum Vitamin D Level in Pediatric Alopecia Areata |
| title_full | Serum Vitamin D Level in Pediatric Alopecia Areata |
| title_fullStr | Serum Vitamin D Level in Pediatric Alopecia Areata |
| title_full_unstemmed | Serum Vitamin D Level in Pediatric Alopecia Areata |
| title_short | Serum Vitamin D Level in Pediatric Alopecia Areata |
| title_sort | serum vitamin d level in pediatric alopecia areata |
| topic | alopecia areata autoimmune diseases pediatric severity of alopecia tool score vitamin d |
| url | https://journals.lww.com/10.4103/ijpd.ijpd_53_23 |
| work_keys_str_mv | AT snehasonker serumvitamindlevelinpediatricalopeciaareata AT vibhumendiratta serumvitamindlevelinpediatricalopeciaareata AT ektadebnath serumvitamindlevelinpediatricalopeciaareata |