Risankizumab and guselkumab for psoriasis: a 1-year real-world practice indirect comparison
Abstract Background: Psoriasis is a chronic inflammatory skin disease with a genetic predisposition and autoimmune component, often treated with immunomodulators such as biologic therapies. Objectives: In this study, the authors evaluated the effectiveness and safety of two of these over a 52-week...
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Sociedade Brasileira de Dermatologia
2025-04-01
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| Series: | Anais Brasileiros de Dermatologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962025000200305&lng=en&tlng=en |
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| author | Leyla Baykal Selçuk Hande Ermiş Akkuş Burak Akşan Deniz Aksu Arıca |
| author_facet | Leyla Baykal Selçuk Hande Ermiş Akkuş Burak Akşan Deniz Aksu Arıca |
| author_sort | Leyla Baykal Selçuk |
| collection | DOAJ |
| description | Abstract Background: Psoriasis is a chronic inflammatory skin disease with a genetic predisposition and autoimmune component, often treated with immunomodulators such as biologic therapies. Objectives: In this study, the authors evaluated the effectiveness and safety of two of these over a 52-week treatment period. Methods: A double-center retrospective cohort study was conducted, enrolling patients with moderate to severe psoriasis who received either guselkumab or risankizumab at dermatology clinics for a minimum of 52-weeks. Result: Out of the 90 patients enrolled in the study, 49 (54.4%) received guselkumab, while 41 (45.6%) received risankizumab. Regarding therapy efficiency, there was no statistically significant difference in PASI90 and PASI100 at week 4 between the two groups (p = 0.428, p = 0.750, respectively). By week 16, PASI90 responses were higher in the guselkumab group (p = 0.039). However, there was no difference in PASI100 response at week 16 (p = 0.957). At weeks 24 and 52, PASI90 and PASI100 responses were similar in both groups. Our results demonstrated that both guselkumab and risankizumab were effective in patients who had previously failed other biologics. Clinical outcomes in both the guselkumab and risankizumab groups had remained unaffected during prior biologic treatments, including anti-TNF, anti-IL17, and/or anti-IL12/23. Treatments yielded consistent outcomes regardless of factors such as obesity, gender, and comorbidities. Study limitations: The small sample size. Conclusions: Our results demonstrated that both guselkumab and risankizumab were effective in patients who had previously failed other biologics. Clinical outcomes in both the guselkumab and risankizumab groups had remained unaffected during prior biologic treatments, including anti-TNF, anti-IL17, and/or anti-IL12/23. Treatments yielded consistent outcomes regardless of factors such as obesity, gender, and comorbidities. |
| format | Article |
| id | doaj-art-6ab8fb2ae6c34aeabd48e8fcfc369cbd |
| institution | OA Journals |
| issn | 0365-0596 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj-art-6ab8fb2ae6c34aeabd48e8fcfc369cbd2025-08-20T02:10:41ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962025-04-01100210.1016/j.abd.2024.05.005Risankizumab and guselkumab for psoriasis: a 1-year real-world practice indirect comparisonLeyla Baykal Selçukhttps://orcid.org/0000-0001-7956-4033Hande Ermiş Akkuşhttps://orcid.org/0000-0002-1431-2203Burak Akşanhttps://orcid.org/0000-0002-3052-5014Deniz Aksu Arıcahttps://orcid.org/0000-0003-3755-4325Abstract Background: Psoriasis is a chronic inflammatory skin disease with a genetic predisposition and autoimmune component, often treated with immunomodulators such as biologic therapies. Objectives: In this study, the authors evaluated the effectiveness and safety of two of these over a 52-week treatment period. Methods: A double-center retrospective cohort study was conducted, enrolling patients with moderate to severe psoriasis who received either guselkumab or risankizumab at dermatology clinics for a minimum of 52-weeks. Result: Out of the 90 patients enrolled in the study, 49 (54.4%) received guselkumab, while 41 (45.6%) received risankizumab. Regarding therapy efficiency, there was no statistically significant difference in PASI90 and PASI100 at week 4 between the two groups (p = 0.428, p = 0.750, respectively). By week 16, PASI90 responses were higher in the guselkumab group (p = 0.039). However, there was no difference in PASI100 response at week 16 (p = 0.957). At weeks 24 and 52, PASI90 and PASI100 responses were similar in both groups. Our results demonstrated that both guselkumab and risankizumab were effective in patients who had previously failed other biologics. Clinical outcomes in both the guselkumab and risankizumab groups had remained unaffected during prior biologic treatments, including anti-TNF, anti-IL17, and/or anti-IL12/23. Treatments yielded consistent outcomes regardless of factors such as obesity, gender, and comorbidities. Study limitations: The small sample size. Conclusions: Our results demonstrated that both guselkumab and risankizumab were effective in patients who had previously failed other biologics. Clinical outcomes in both the guselkumab and risankizumab groups had remained unaffected during prior biologic treatments, including anti-TNF, anti-IL17, and/or anti-IL12/23. Treatments yielded consistent outcomes regardless of factors such as obesity, gender, and comorbidities.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962025000200305&lng=en&tlng=enBiological productsGuselkumabPsoriasisRisankizumab |
| spellingShingle | Leyla Baykal Selçuk Hande Ermiş Akkuş Burak Akşan Deniz Aksu Arıca Risankizumab and guselkumab for psoriasis: a 1-year real-world practice indirect comparison Anais Brasileiros de Dermatologia Biological products Guselkumab Psoriasis Risankizumab |
| title | Risankizumab and guselkumab for psoriasis: a 1-year real-world practice indirect comparison |
| title_full | Risankizumab and guselkumab for psoriasis: a 1-year real-world practice indirect comparison |
| title_fullStr | Risankizumab and guselkumab for psoriasis: a 1-year real-world practice indirect comparison |
| title_full_unstemmed | Risankizumab and guselkumab for psoriasis: a 1-year real-world practice indirect comparison |
| title_short | Risankizumab and guselkumab for psoriasis: a 1-year real-world practice indirect comparison |
| title_sort | risankizumab and guselkumab for psoriasis a 1 year real world practice indirect comparison |
| topic | Biological products Guselkumab Psoriasis Risankizumab |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962025000200305&lng=en&tlng=en |
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