The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
MicroRNA-378a (miR-378a, previously known as miR-378) is one of the small noncoding RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature strands, miR-378a-3p and miR-378a-5p, originate from the first intron of the peroxisome proliferator-activated receptor gamm...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/281756 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551320582619136 |
|---|---|
| author | Bart Krist Urszula Florczyk Katarzyna Pietraszek-Gremplewicz Alicja Józkowicz Jozef Dulak |
| author_facet | Bart Krist Urszula Florczyk Katarzyna Pietraszek-Gremplewicz Alicja Józkowicz Jozef Dulak |
| author_sort | Bart Krist |
| collection | DOAJ |
| description | MicroRNA-378a (miR-378a, previously known as miR-378) is one of the small noncoding RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature strands, miR-378a-3p and miR-378a-5p, originate from the first intron of the peroxisome proliferator-activated receptor gamma, coactivator 1 beta (ppargc1b) gene encoding PGC-1β. Embedding in the sequence of this transcriptional regulator of oxidative energy metabolism implies involvement of miR-378a in metabolic pathways, mitochondrial energy homeostasis, and related biological processes such as muscle development, differentiation, and regeneration. On the other hand, modulating the expression of proangiogenic factors such as vascular endothelial growth factor, angiopoietin-1, or interleukin-8, influencing inflammatory reaction, and affecting tumor suppressors, such as SuFu and Fus-1, miR-378a is considered as a part of an angiogenic network in tumors. In the latter, miR-378a can evoke broader actions by enhancing cell survival, reducing apoptosis, and promoting cell migration and invasion. This review describes the current knowledge on miR-378a linking oxidative/lipid metabolism, muscle biology, and blood vessel formation. |
| format | Article |
| id | doaj-art-6ab371e2dde142a8b41d1aa1f4278bed |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6ab371e2dde142a8b41d1aa1f4278bed2025-02-03T06:01:45ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/281756281756The Role of miR-378a in Metabolism, Angiogenesis, and Muscle BiologyBart Krist0Urszula Florczyk1Katarzyna Pietraszek-Gremplewicz2Alicja Józkowicz3Jozef Dulak4Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30–387 Krakow, PolandDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30–387 Krakow, PolandDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30–387 Krakow, PolandDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30–387 Krakow, PolandDepartment of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30–387 Krakow, PolandMicroRNA-378a (miR-378a, previously known as miR-378) is one of the small noncoding RNA molecules able to regulate gene expression at posttranscriptional level. Its two mature strands, miR-378a-3p and miR-378a-5p, originate from the first intron of the peroxisome proliferator-activated receptor gamma, coactivator 1 beta (ppargc1b) gene encoding PGC-1β. Embedding in the sequence of this transcriptional regulator of oxidative energy metabolism implies involvement of miR-378a in metabolic pathways, mitochondrial energy homeostasis, and related biological processes such as muscle development, differentiation, and regeneration. On the other hand, modulating the expression of proangiogenic factors such as vascular endothelial growth factor, angiopoietin-1, or interleukin-8, influencing inflammatory reaction, and affecting tumor suppressors, such as SuFu and Fus-1, miR-378a is considered as a part of an angiogenic network in tumors. In the latter, miR-378a can evoke broader actions by enhancing cell survival, reducing apoptosis, and promoting cell migration and invasion. This review describes the current knowledge on miR-378a linking oxidative/lipid metabolism, muscle biology, and blood vessel formation.http://dx.doi.org/10.1155/2015/281756 |
| spellingShingle | Bart Krist Urszula Florczyk Katarzyna Pietraszek-Gremplewicz Alicja Józkowicz Jozef Dulak The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology International Journal of Endocrinology |
| title | The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology |
| title_full | The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology |
| title_fullStr | The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology |
| title_full_unstemmed | The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology |
| title_short | The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology |
| title_sort | role of mir 378a in metabolism angiogenesis and muscle biology |
| url | http://dx.doi.org/10.1155/2015/281756 |
| work_keys_str_mv | AT bartkrist theroleofmir378ainmetabolismangiogenesisandmusclebiology AT urszulaflorczyk theroleofmir378ainmetabolismangiogenesisandmusclebiology AT katarzynapietraszekgremplewicz theroleofmir378ainmetabolismangiogenesisandmusclebiology AT alicjajozkowicz theroleofmir378ainmetabolismangiogenesisandmusclebiology AT jozefdulak theroleofmir378ainmetabolismangiogenesisandmusclebiology AT bartkrist roleofmir378ainmetabolismangiogenesisandmusclebiology AT urszulaflorczyk roleofmir378ainmetabolismangiogenesisandmusclebiology AT katarzynapietraszekgremplewicz roleofmir378ainmetabolismangiogenesisandmusclebiology AT alicjajozkowicz roleofmir378ainmetabolismangiogenesisandmusclebiology AT jozefdulak roleofmir378ainmetabolismangiogenesisandmusclebiology |