A pediatric case of hepatitis A (genotype IIIA) with biliary stasis-type liver dysfunction and dyslipidemia
Hepatitis A is fecally transmitted through water or food contaminated with the virus. Owing to improved sanitary conditions, the number of reported cases in Japan has decreased, and imported cases are more common. Hepatitis A rarely causes biliary stasis; it has been reported in adults, but not in c...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Journal of Clinical and Translational Endocrinology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214624525000036 |
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| author | Kosuke Oikawa Motohiro Taki Takaaki Takayanagi Shunseki Koyama Shinji Asayama Hiroyuki Satoh |
| author_facet | Kosuke Oikawa Motohiro Taki Takaaki Takayanagi Shunseki Koyama Shinji Asayama Hiroyuki Satoh |
| author_sort | Kosuke Oikawa |
| collection | DOAJ |
| description | Hepatitis A is fecally transmitted through water or food contaminated with the virus. Owing to improved sanitary conditions, the number of reported cases in Japan has decreased, and imported cases are more common. Hepatitis A rarely causes biliary stasis; it has been reported in adults, but not in children. In viral hepatitis, cholesterol levels are often low owing to impaired liver function. Here, we report a pediatric case of hepatitis A with biliary stasis and lipid abnormalities. The patient was a 9-year-old Indian boy living in Japan. He travelled to India and played in a river. Two months after returning to Japan, his parents noticed yellowing of the eyes and brownish urine. Laboratory results showed biliary stasis-type liver dysfunction (aspartate transaminase, 153 IU/L, alanine transaminase, 714 IU/L, γ-glutamyl transaminase, 221 IU/L) and hyperlipidemia (triglycerides 252 mg/dL, LDL cholesterol 248 mg/dL, HDL cholesterol 12 mg/dL). Polymerase chain reaction testing for ribonucleic acid of hepatitis A virus revealed a diagnosis of hepatitis A (genotype IIIA). Treatment consisted of bed rest and intravenous infusion, and the patient's hematological abnormalities resolved spontaneously. |
| format | Article |
| id | doaj-art-6ab1d7ee8ced407194336f3d2d9e1d11 |
| institution | Kabale University |
| issn | 2214-6245 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical and Translational Endocrinology Case Reports |
| spelling | doaj-art-6ab1d7ee8ced407194336f3d2d9e1d112025-08-20T03:25:59ZengElsevierJournal of Clinical and Translational Endocrinology Case Reports2214-62452025-06-013610018410.1016/j.jecr.2025.100184A pediatric case of hepatitis A (genotype IIIA) with biliary stasis-type liver dysfunction and dyslipidemiaKosuke Oikawa0Motohiro Taki1Takaaki Takayanagi2Shunseki Koyama3Shinji Asayama4Hiroyuki Satoh5Department of Pediatrics, Tokyo Metropolitan Ebara Hospital, 4-5-10 Higashiyukigaya, Ota-ku, Tokyo, Japan; Department of Pediatrics, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan; Department of Hygiene, Public Health and Preventive Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan; Corresponding author. Department of Pediatrics, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.Department of Pediatrics, Tokyo Metropolitan Ebara Hospital, 4-5-10 Higashiyukigaya, Ota-ku, Tokyo, Japan; Department of Pediatrics, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, JapanDepartment of Pediatrics, Tokyo Metropolitan Ebara Hospital, 4-5-10 Higashiyukigaya, Ota-ku, Tokyo, Japan; Department of Pediatrics, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, JapanDepartment of Pediatrics, Tokyo Metropolitan Ebara Hospital, 4-5-10 Higashiyukigaya, Ota-ku, Tokyo, JapanDepartment of Pediatrics, Tokyo Metropolitan Ebara Hospital, 4-5-10 Higashiyukigaya, Ota-ku, Tokyo, Japan; Department of Pediatrics, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, JapanDepartment of Pediatrics, Tokyo Metropolitan Ebara Hospital, 4-5-10 Higashiyukigaya, Ota-ku, Tokyo, Japan; Department of Pediatrics, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, JapanHepatitis A is fecally transmitted through water or food contaminated with the virus. Owing to improved sanitary conditions, the number of reported cases in Japan has decreased, and imported cases are more common. Hepatitis A rarely causes biliary stasis; it has been reported in adults, but not in children. In viral hepatitis, cholesterol levels are often low owing to impaired liver function. Here, we report a pediatric case of hepatitis A with biliary stasis and lipid abnormalities. The patient was a 9-year-old Indian boy living in Japan. He travelled to India and played in a river. Two months after returning to Japan, his parents noticed yellowing of the eyes and brownish urine. Laboratory results showed biliary stasis-type liver dysfunction (aspartate transaminase, 153 IU/L, alanine transaminase, 714 IU/L, γ-glutamyl transaminase, 221 IU/L) and hyperlipidemia (triglycerides 252 mg/dL, LDL cholesterol 248 mg/dL, HDL cholesterol 12 mg/dL). Polymerase chain reaction testing for ribonucleic acid of hepatitis A virus revealed a diagnosis of hepatitis A (genotype IIIA). Treatment consisted of bed rest and intravenous infusion, and the patient's hematological abnormalities resolved spontaneously.http://www.sciencedirect.com/science/article/pii/S2214624525000036Biliary stasisHepatitis ALipid disordersLiver dysfunctionPediatrics |
| spellingShingle | Kosuke Oikawa Motohiro Taki Takaaki Takayanagi Shunseki Koyama Shinji Asayama Hiroyuki Satoh A pediatric case of hepatitis A (genotype IIIA) with biliary stasis-type liver dysfunction and dyslipidemia Journal of Clinical and Translational Endocrinology Case Reports Biliary stasis Hepatitis A Lipid disorders Liver dysfunction Pediatrics |
| title | A pediatric case of hepatitis A (genotype IIIA) with biliary stasis-type liver dysfunction and dyslipidemia |
| title_full | A pediatric case of hepatitis A (genotype IIIA) with biliary stasis-type liver dysfunction and dyslipidemia |
| title_fullStr | A pediatric case of hepatitis A (genotype IIIA) with biliary stasis-type liver dysfunction and dyslipidemia |
| title_full_unstemmed | A pediatric case of hepatitis A (genotype IIIA) with biliary stasis-type liver dysfunction and dyslipidemia |
| title_short | A pediatric case of hepatitis A (genotype IIIA) with biliary stasis-type liver dysfunction and dyslipidemia |
| title_sort | pediatric case of hepatitis a genotype iiia with biliary stasis type liver dysfunction and dyslipidemia |
| topic | Biliary stasis Hepatitis A Lipid disorders Liver dysfunction Pediatrics |
| url | http://www.sciencedirect.com/science/article/pii/S2214624525000036 |
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