A pediatric case of hepatitis A (genotype IIIA) with biliary stasis-type liver dysfunction and dyslipidemia
Hepatitis A is fecally transmitted through water or food contaminated with the virus. Owing to improved sanitary conditions, the number of reported cases in Japan has decreased, and imported cases are more common. Hepatitis A rarely causes biliary stasis; it has been reported in adults, but not in c...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | Journal of Clinical and Translational Endocrinology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214624525000036 |
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| Summary: | Hepatitis A is fecally transmitted through water or food contaminated with the virus. Owing to improved sanitary conditions, the number of reported cases in Japan has decreased, and imported cases are more common. Hepatitis A rarely causes biliary stasis; it has been reported in adults, but not in children. In viral hepatitis, cholesterol levels are often low owing to impaired liver function. Here, we report a pediatric case of hepatitis A with biliary stasis and lipid abnormalities. The patient was a 9-year-old Indian boy living in Japan. He travelled to India and played in a river. Two months after returning to Japan, his parents noticed yellowing of the eyes and brownish urine. Laboratory results showed biliary stasis-type liver dysfunction (aspartate transaminase, 153 IU/L, alanine transaminase, 714 IU/L, γ-glutamyl transaminase, 221 IU/L) and hyperlipidemia (triglycerides 252 mg/dL, LDL cholesterol 248 mg/dL, HDL cholesterol 12 mg/dL). Polymerase chain reaction testing for ribonucleic acid of hepatitis A virus revealed a diagnosis of hepatitis A (genotype IIIA). Treatment consisted of bed rest and intravenous infusion, and the patient's hematological abnormalities resolved spontaneously. |
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| ISSN: | 2214-6245 |