A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015
Abstract Background To estimate the burden of invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, and acute otitis media before and after inclusion of the 13-valent pneumococcal vaccine (PCV13) into Taiwan’s Childhood Immunization Program in 2015. Methods Episodes of eligible child...
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2025-02-01
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| Online Access: | https://doi.org/10.1186/s12879-024-10379-z |
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| author | Ting-An Yen Jhong-Lin Wu Chi-Chuan Wang Ling-Ya Huang See-Hwee Yeo Dony Patel Cindy Thiow Koon Lim Hung-Wei Lin Eriko Yamada Isaya Sukarom |
| author_facet | Ting-An Yen Jhong-Lin Wu Chi-Chuan Wang Ling-Ya Huang See-Hwee Yeo Dony Patel Cindy Thiow Koon Lim Hung-Wei Lin Eriko Yamada Isaya Sukarom |
| author_sort | Ting-An Yen |
| collection | DOAJ |
| description | Abstract Background To estimate the burden of invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, and acute otitis media before and after inclusion of the 13-valent pneumococcal vaccine (PCV13) into Taiwan’s Childhood Immunization Program in 2015. Methods Episodes of eligible children aged < 18 years hospitalized with invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, or acute otitis media between 1 January 2011 and 31 December 2019 were identified from the National Health Insurance Research Database. Annual hospitalized incidence rate, case fatality rate, and healthcare resource utilization and costs were estimated. Incidence time trends were assessed with interrupted time series analyses. Results 1,284 invasive pneumococcal disease episodes, 25,074 non-bacteremic pneumococcal pneumonia episodes, and 23,139 acute otitis media episodes were identified. The overall annual incidence rates of invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, and acute otitis media were 3.31, 64.61, and 59.62 episodes per 100,000 person-years, respectively. Interrupted time series analyses results showed a significantly lower baseline incidence rate (incidence rate ratio [IRR]:0.58, p-value = 0.001) for invasive pneumococcal disease, and significantly higher baseline incidence rate (IRR:1.17, p-value < 0.001) for non-bacteremic pneumococcal pneumonia in the post-PCV13 period. Baseline incidence rates between the two periods were comparable for acute otitis media. A significant increase in trend of incidence rate was observed for all three diseases. Case fatality rate was 1.79%, 0.09%, and 0.00% for invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, and acute otitis media, respectively. Median length of hospitalization per inpatient visit was comparable between the two periods for invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia, but significantly shorter in the post-PCV13 period for acute otitis media. In the post-PCV13 period, average total costs per episode was lower for invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia, but higher for acute otitis media. Conclusions Residual clinical and economic burden of pneumococcal diseases remained substantial after PCV13 inclusion into Taiwan’s Childhood Immunization Program. To further reduce the disease burden among children, additional research to investigate the cause of increasing trends of hospitalized invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia and acute otitis media in the post-PCV13 era will be required. |
| format | Article |
| id | doaj-art-6aae3edf7d5e483aa254b8593f4c4d87 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Infectious Diseases |
| spelling | doaj-art-6aae3edf7d5e483aa254b8593f4c4d872025-02-09T12:14:31ZengBMCBMC Infectious Diseases1471-23342025-02-0125111510.1186/s12879-024-10379-zA population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015Ting-An Yen0Jhong-Lin Wu1Chi-Chuan Wang2Ling-Ya Huang3See-Hwee Yeo4Dony Patel5Cindy Thiow Koon Lim6Hung-Wei Lin7Eriko Yamada8Isaya Sukarom9Department of Pediatrics, National Taiwan University HospitalDepartment of Emergency Medicine, National Taiwan University HospitalSchool of Pharmacy, College of Medicine, National Taiwan UniversitySchool of Pharmacy, College of Medicine, National Taiwan UniversityReal World Solutions, IQVIA Solutions AsiaGlobal Database Studies, Real World Solutions, IQVIAReal World Solutions, IQVIA Solutions AsiaReal World Solutions, IQVIA Solutions TaiwanGlobal Medical and Scientific Affairs, MSD SingaporeRegional Outcomes Research, MSD ThailandAbstract Background To estimate the burden of invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, and acute otitis media before and after inclusion of the 13-valent pneumococcal vaccine (PCV13) into Taiwan’s Childhood Immunization Program in 2015. Methods Episodes of eligible children aged < 18 years hospitalized with invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, or acute otitis media between 1 January 2011 and 31 December 2019 were identified from the National Health Insurance Research Database. Annual hospitalized incidence rate, case fatality rate, and healthcare resource utilization and costs were estimated. Incidence time trends were assessed with interrupted time series analyses. Results 1,284 invasive pneumococcal disease episodes, 25,074 non-bacteremic pneumococcal pneumonia episodes, and 23,139 acute otitis media episodes were identified. The overall annual incidence rates of invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, and acute otitis media were 3.31, 64.61, and 59.62 episodes per 100,000 person-years, respectively. Interrupted time series analyses results showed a significantly lower baseline incidence rate (incidence rate ratio [IRR]:0.58, p-value = 0.001) for invasive pneumococcal disease, and significantly higher baseline incidence rate (IRR:1.17, p-value < 0.001) for non-bacteremic pneumococcal pneumonia in the post-PCV13 period. Baseline incidence rates between the two periods were comparable for acute otitis media. A significant increase in trend of incidence rate was observed for all three diseases. Case fatality rate was 1.79%, 0.09%, and 0.00% for invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia, and acute otitis media, respectively. Median length of hospitalization per inpatient visit was comparable between the two periods for invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia, but significantly shorter in the post-PCV13 period for acute otitis media. In the post-PCV13 period, average total costs per episode was lower for invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia, but higher for acute otitis media. Conclusions Residual clinical and economic burden of pneumococcal diseases remained substantial after PCV13 inclusion into Taiwan’s Childhood Immunization Program. To further reduce the disease burden among children, additional research to investigate the cause of increasing trends of hospitalized invasive pneumococcal disease, non-bacteremic pneumococcal pneumonia and acute otitis media in the post-PCV13 era will be required.https://doi.org/10.1186/s12879-024-10379-zPneumococcal conjugate vaccineInvasive pneumococcal diseaseNon-bacteremic pneumococcal pneumoniaAcute otitis mediaTaiwan |
| spellingShingle | Ting-An Yen Jhong-Lin Wu Chi-Chuan Wang Ling-Ya Huang See-Hwee Yeo Dony Patel Cindy Thiow Koon Lim Hung-Wei Lin Eriko Yamada Isaya Sukarom A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015 BMC Infectious Diseases Pneumococcal conjugate vaccine Invasive pneumococcal disease Non-bacteremic pneumococcal pneumonia Acute otitis media Taiwan |
| title | A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015 |
| title_full | A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015 |
| title_fullStr | A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015 |
| title_full_unstemmed | A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015 |
| title_short | A population-based study on the burden of hospitalized pediatric pneumococcal disease in Taiwan before and after the introduction of 13-valent pneumococcal conjugate vaccine into the childhood immunization program in 2015 |
| title_sort | population based study on the burden of hospitalized pediatric pneumococcal disease in taiwan before and after the introduction of 13 valent pneumococcal conjugate vaccine into the childhood immunization program in 2015 |
| topic | Pneumococcal conjugate vaccine Invasive pneumococcal disease Non-bacteremic pneumococcal pneumonia Acute otitis media Taiwan |
| url | https://doi.org/10.1186/s12879-024-10379-z |
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