Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease
Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. Fourteen cy...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3604842 |
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| _version_ | 1849414865517543424 |
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| author | Senthooran Selvarajah Ian Todd Patrick J. Tighe Michelle John Charlotte E. Bolton Timothy Harrison Lucy C. Fairclough |
| author_facet | Senthooran Selvarajah Ian Todd Patrick J. Tighe Michelle John Charlotte E. Bolton Timothy Harrison Lucy C. Fairclough |
| author_sort | Senthooran Selvarajah |
| collection | DOAJ |
| description | Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. Fourteen cytokines were measured in serum from never-smokers, ex-smokers, current smokers, and COPD patients (GOLD stages 1–3). Certain individual circulating cytokines (particularly TNFα and IL-1β) were significantly elevated in concentration in the serum of particular COPD patients (and some current/ex-smokers without COPD) and may serve as markers of particularly significant systemic inflammation. However, numerous circulating cytokines were raised such that their combined, but not individual, elevation was significantly associated with severity of disease, and these may be further indicators of, and contributors to, the systemic inflammatory manifestations of COPD. The coelevation of numerous circulating cytokines in COPD is consistent with the insidious development, chronic nature, and systemic comorbidities of the disease. |
| format | Article |
| id | doaj-art-6aabfe3a0b054d5d8bf5c2d30a1f8b98 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6aabfe3a0b054d5d8bf5c2d30a1f8b982025-08-20T03:33:41ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/36048423604842Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary DiseaseSenthooran Selvarajah0Ian Todd1Patrick J. Tighe2Michelle John3Charlotte E. Bolton4Timothy Harrison5Lucy C. Fairclough6School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UKSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UKSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UKNottingham Respiratory Research Unit, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UKNottingham Respiratory Research Unit, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UKNottingham Respiratory Research Unit, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UKSchool of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UKInflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. Fourteen cytokines were measured in serum from never-smokers, ex-smokers, current smokers, and COPD patients (GOLD stages 1–3). Certain individual circulating cytokines (particularly TNFα and IL-1β) were significantly elevated in concentration in the serum of particular COPD patients (and some current/ex-smokers without COPD) and may serve as markers of particularly significant systemic inflammation. However, numerous circulating cytokines were raised such that their combined, but not individual, elevation was significantly associated with severity of disease, and these may be further indicators of, and contributors to, the systemic inflammatory manifestations of COPD. The coelevation of numerous circulating cytokines in COPD is consistent with the insidious development, chronic nature, and systemic comorbidities of the disease.http://dx.doi.org/10.1155/2016/3604842 |
| spellingShingle | Senthooran Selvarajah Ian Todd Patrick J. Tighe Michelle John Charlotte E. Bolton Timothy Harrison Lucy C. Fairclough Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease Mediators of Inflammation |
| title | Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease |
| title_full | Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease |
| title_fullStr | Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease |
| title_short | Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease |
| title_sort | multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease |
| url | http://dx.doi.org/10.1155/2016/3604842 |
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