Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia
Large-scale study of regulation and disadaptation mechanisms of blood system in hypoxia of different genesis is performed. Negative influence of encephalopathy and associated with it adrenergic system activation on hemopoiesis is shown which manifests in disturbed erythropoiesis and production of pa...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2006-06-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3064 |
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| _version_ | 1849241113510019072 |
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| author | Ye. D. Goldberg A. M. Dygai G. N. Zyuz’Kov |
| author_facet | Ye. D. Goldberg A. M. Dygai G. N. Zyuz’Kov |
| author_sort | Ye. D. Goldberg |
| collection | DOAJ |
| description | Large-scale study of regulation and disadaptation mechanisms of blood system in hypoxia of different genesis is performed. Negative influence of encephalopathy and associated with it adrenergic system activation on hemopoiesis is shown which manifests in disturbed erythropoiesis and production of pathologic forms of erythrocytes. Participation of bone marrow mesenchimal stem cells and increased content of neural cells-precursors in central nervous system in conditions of oxygen deficiency are revealed. Failure of the given adaptation mechanisms of “deep reserve” in severe hypoxia which manifests in the development of encephalopathy and disadaptation of hemopoietic tissue is revealed. |
| format | Article |
| id | doaj-art-6aab198f1ae84ba49198294325ae6eeb |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2006-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-6aab198f1ae84ba49198294325ae6eeb2025-08-20T04:00:18ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842006-06-0152435110.20538/1682-0363-2006-2-43-511722Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxiaYe. D. Goldberg0A. M. Dygai1G. N. Zyuz’Kov2НИИ фармакологии ТНЦ СО РАМННИИ фармакологии ТНЦ СО РАМННИИ фармакологии ТНЦ СО РАМНLarge-scale study of regulation and disadaptation mechanisms of blood system in hypoxia of different genesis is performed. Negative influence of encephalopathy and associated with it adrenergic system activation on hemopoiesis is shown which manifests in disturbed erythropoiesis and production of pathologic forms of erythrocytes. Participation of bone marrow mesenchimal stem cells and increased content of neural cells-precursors in central nervous system in conditions of oxygen deficiency are revealed. Failure of the given adaptation mechanisms of “deep reserve” in severe hypoxia which manifests in the development of encephalopathy and disadaptation of hemopoietic tissue is revealed.https://bulletin.ssmu.ru/jour/article/view/3064гипоксияэнцефалопатиягемопоэзгемопоэзиндуцирующее микроокружениемезенхимальные стволовые клеткинейральные клетки-предшественникиhypoxiaencephalopathyhemopoiesishemopoiesis-induced micro-environmentmesenchimal stem cellsneural cells-precursors |
| spellingShingle | Ye. D. Goldberg A. M. Dygai G. N. Zyuz’Kov Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia Бюллетень сибирской медицины гипоксия энцефалопатия гемопоэз гемопоэзиндуцирующее микроокружение мезенхимальные стволовые клетки нейральные клетки-предшественники hypoxia encephalopathy hemopoiesis hemopoiesis-induced micro-environment mesenchimal stem cells neural cells-precursors |
| title | Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia |
| title_full | Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia |
| title_fullStr | Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia |
| title_full_unstemmed | Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia |
| title_short | Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia |
| title_sort | blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia |
| topic | гипоксия энцефалопатия гемопоэз гемопоэзиндуцирующее микроокружение мезенхимальные стволовые клетки нейральные клетки-предшественники hypoxia encephalopathy hemopoiesis hemopoiesis-induced micro-environment mesenchimal stem cells neural cells-precursors |
| url | https://bulletin.ssmu.ru/jour/article/view/3064 |
| work_keys_str_mv | AT yedgoldberg bloodsystemregulationmechanismsinoxygeninsufficiencyandparticipationofneuralstemcellsintheadaptationtohypoxia AT amdygai bloodsystemregulationmechanismsinoxygeninsufficiencyandparticipationofneuralstemcellsintheadaptationtohypoxia AT gnzyuzkov bloodsystemregulationmechanismsinoxygeninsufficiencyandparticipationofneuralstemcellsintheadaptationtohypoxia |