Plasmodium falciparum multidrug resistance 1 gene polymorphisms associated with outcomes after anti-malarial treatment

Plasmodium falciparum multidrug resistance 1 gene polymorphisms associated with outcomes after anti-malarial treatment

Abstract Background Plasmodium falciparum multidrug resistance transporter 1 (Pfmdr1) gene mutations are associated with altered response to artemisinin-based combination therapy (ACT), particularly the combinations containing the partner drugs lumefantrine and amodiaquine (i.e., artemether-lumefant...

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Main Authors: Veronika R. Laird, Mateusz M. Plucinski, Meera Venkatesan, Kelsey A. Rondini, Milijaona Randrianarivelojosia, Mauricette N. Andriamananjara, Hawela Moonga, Deus S. Ishengoma, Arlindo Chidimatembue, Pedro Rafael Dimbu, Adicatou-Laï Adeothy, Abdoul Habib Beavogui, Simon Kariuki, Sam L. Nsobya, Aline Uwimana, Gauthier Mesia Kahunu, Ashenafi Assefa, Ousmane A. Koita, Naomi W. Lucchi, Samaly S. Svigel Souza, Zhiyong Zhou, Leah F. Moriarty, Eric S. Halsey
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
Africa
Antimalarials
Drug resistance
Online Access:https://doi.org/10.1186/s12936-025-05248-2
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