Magnesium ions attenuate tendon graft fibrosis during its ligamentization after ACL reconstruction through modulation of fibroblast to myofibroblast trans-differentiation by promoting PGE2 secretion

Magnesium ions attenuate tendon graft fibrosis during its ligamentization after ACL reconstruction through modulation of fibroblast to myofibroblast trans-differentiation by promoting PGE2 secretion

The ligamentization process of the tendon graft in anterior cruciate ligament (ACL) reconstruction is crucial for graft healing quality, thereby affecting knee joint function. Excessive scar tissue, caused by activation of trans-differentiation of fibroblasts to myofibroblasts, rather than orientate...

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Bibliographic Details
Main Authors: Changhao Xu, Ying Luo, Zhining Cai, Jiali Ji, Zhiyu Guo, Zhaoji Cai, Chao You, Yibiao Zhou, Zhuoxuan Chen, Weijia Zhang, Ningji Gong, Jiali Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-10-01
Series:Bioactive Materials
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25002476
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