Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology
Rheumatoid arthritis (RA) is an immune-mediated rheumatic disease (IMRDs) characterized by chronic erosive arthritis and systemic damage to internal organs, leading to early disability and reduced life expectancy in patients. A particularly important place among the systemic manifestations of RA is...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2022-12-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/3242 |
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| author | E. L. Nasonov L. P. Ananyeva S. N. Avdeev |
| author_facet | E. L. Nasonov L. P. Ananyeva S. N. Avdeev |
| author_sort | E. L. Nasonov |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is an immune-mediated rheumatic disease (IMRDs) characterized by chronic erosive arthritis and systemic damage to internal organs, leading to early disability and reduced life expectancy in patients. A particularly important place among the systemic manifestations of RA is occupied by interstitial lung diseases (ILD) – the most severe form of pulmonary pathology in RA, defined as RA-ILD, which is pathogenetically associated with risk factors (smoking, etc.) and autoimmune mechanisms underlying RA. RA-ILD is a subtype of RA characterized by a severe course and a poor prognosis. The review presents new data regarding risk factors and biomarkers for RA-ILD; modern diagnostic capabilities based on the use of functional lung tests, high-resolution computed tomography, ultrasound examination of the lungs. Particular attention is paid to the efficacy and safety of pharmacotherapy, including methotrexate, biologics, JAK inhibitors, and antifibrotic therapy. An algorithm for the pharmacotherapy of RA-ILD has been proposed. |
| format | Article |
| id | doaj-art-6aa1a7c164a64ee2bba6cff45fa2e18c |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-6aa1a7c164a64ee2bba6cff45fa2e18c2025-08-20T03:37:53ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922022-12-0160651753410.47360/1995-4484-2022-12855Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonologyE. L. Nasonov0L. P. Ananyeva1S. N. Avdeev2V.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)V.A. Nasonova Research Institute of RheumatologyI.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)Rheumatoid arthritis (RA) is an immune-mediated rheumatic disease (IMRDs) characterized by chronic erosive arthritis and systemic damage to internal organs, leading to early disability and reduced life expectancy in patients. A particularly important place among the systemic manifestations of RA is occupied by interstitial lung diseases (ILD) – the most severe form of pulmonary pathology in RA, defined as RA-ILD, which is pathogenetically associated with risk factors (smoking, etc.) and autoimmune mechanisms underlying RA. RA-ILD is a subtype of RA characterized by a severe course and a poor prognosis. The review presents new data regarding risk factors and biomarkers for RA-ILD; modern diagnostic capabilities based on the use of functional lung tests, high-resolution computed tomography, ultrasound examination of the lungs. Particular attention is paid to the efficacy and safety of pharmacotherapy, including methotrexate, biologics, JAK inhibitors, and antifibrotic therapy. An algorithm for the pharmacotherapy of RA-ILD has been proposed.https://rsp.mediar-press.net/rsp/article/view/3242rheumatoid arthritisinterstitial lung diseasemethotrexatebiologicsjak inhibitorsantifibrotic drugsnintedanib |
| spellingShingle | E. L. Nasonov L. P. Ananyeva S. N. Avdeev Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology Научно-практическая ревматология rheumatoid arthritis interstitial lung disease methotrexate biologics jak inhibitors antifibrotic drugs nintedanib |
| title | Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology |
| title_full | Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology |
| title_fullStr | Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology |
| title_full_unstemmed | Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology |
| title_short | Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology |
| title_sort | interstitial lung disease in rheumatoid arthritis a multidisciplinary problem in rheumatology and pulmonology |
| topic | rheumatoid arthritis interstitial lung disease methotrexate biologics jak inhibitors antifibrotic drugs nintedanib |
| url | https://rsp.mediar-press.net/rsp/article/view/3242 |
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