Association Between Glycation Gap and Renal Complications in People with Type 2 Diabetes
OBJECTIVE: This study’s objective is to ascertain the degree of glycosylation gap in individuals with type 2 diabetes (T2D) and how it relates to renal failure. MATERIAL AND METHODS: 210 participants, ages 25 to 75 years, were enlisted in this study and divided into three groups. Seventy people with...
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Via Medica
2025-01-01
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| Series: | Clinical Diabetology |
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| Online Access: | https://journals.viamedica.pl/clinical_diabetology/article/view/104794 |
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| author | Anwar Jamal Asis Mitra |
| author_facet | Anwar Jamal Asis Mitra |
| author_sort | Anwar Jamal |
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| description | OBJECTIVE: This study’s objective is to ascertain the degree of glycosylation gap in individuals with type 2 diabetes (T2D) and how it relates to renal failure. MATERIAL AND METHODS: 210 participants, ages 25 to 75 years, were enlisted in this study and divided into three groups. Seventy people without diabetes made up Group 1, which acted as a control. Seventy patients with T2D who did not have chronic kidney disease (CKD) were in Group 2, while 70 patients with T2D who did have CKD were in Group 3. All groups had their levels of fructosamine (FA) and glycated hemoglobin (HbA1c) assessed to calculate the mean blood glucose (MBG), projected HbA1c, and glycosylation gap (GG). RESULTS: In comparison to individuals with diabetes and controls (0.886 ± 0.14; 0.921 ± 0.1), patients with CKD had significantly higher serum creatinine levels (1.96 ± 0.88). In comparison to patients without CKD and controls, the study showed a substantial increase in serum FA, measured and projected HbA1c, and MBG in patients with diabetes with CKD. GG was detected in patients with T2D without CKD (0.631 ± 0.44), patients with diabetes with CKD (1 ± 0.96), and healthy controls (–0.52 ± 0.71). CONCLUSIONS: Glycation gap may be associated with renal complication in people with T2D. |
| format | Article |
| id | doaj-art-6a969046b88c4b52b712d8fc7b674e49 |
| institution | Kabale University |
| issn | 2450-7458 2450-8187 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Clinical Diabetology |
| spelling | doaj-art-6a969046b88c4b52b712d8fc7b674e492025-08-21T05:52:11ZengVia MedicaClinical Diabetology2450-74582450-81872025-01-0114310.5603/cd.104794Association Between Glycation Gap and Renal Complications in People with Type 2 DiabetesAnwar Jamal0Asis Mitra1Department of Diabetology, Islamia Hospital, Kolkata, IndiaDepartment of Medicine, Ruby General Hospital, Kolkata, IndiaOBJECTIVE: This study’s objective is to ascertain the degree of glycosylation gap in individuals with type 2 diabetes (T2D) and how it relates to renal failure. MATERIAL AND METHODS: 210 participants, ages 25 to 75 years, were enlisted in this study and divided into three groups. Seventy people without diabetes made up Group 1, which acted as a control. Seventy patients with T2D who did not have chronic kidney disease (CKD) were in Group 2, while 70 patients with T2D who did have CKD were in Group 3. All groups had their levels of fructosamine (FA) and glycated hemoglobin (HbA1c) assessed to calculate the mean blood glucose (MBG), projected HbA1c, and glycosylation gap (GG). RESULTS: In comparison to individuals with diabetes and controls (0.886 ± 0.14; 0.921 ± 0.1), patients with CKD had significantly higher serum creatinine levels (1.96 ± 0.88). In comparison to patients without CKD and controls, the study showed a substantial increase in serum FA, measured and projected HbA1c, and MBG in patients with diabetes with CKD. GG was detected in patients with T2D without CKD (0.631 ± 0.44), patients with diabetes with CKD (1 ± 0.96), and healthy controls (–0.52 ± 0.71). CONCLUSIONS: Glycation gap may be associated with renal complication in people with T2D.https://journals.viamedica.pl/clinical_diabetology/article/view/104794glycosylation gapglycated hemoglobindiabetes mellituschronic kidney diseasefructosamine |
| spellingShingle | Anwar Jamal Asis Mitra Association Between Glycation Gap and Renal Complications in People with Type 2 Diabetes Clinical Diabetology glycosylation gap glycated hemoglobin diabetes mellitus chronic kidney disease fructosamine |
| title | Association Between Glycation Gap and Renal Complications in People with Type 2 Diabetes |
| title_full | Association Between Glycation Gap and Renal Complications in People with Type 2 Diabetes |
| title_fullStr | Association Between Glycation Gap and Renal Complications in People with Type 2 Diabetes |
| title_full_unstemmed | Association Between Glycation Gap and Renal Complications in People with Type 2 Diabetes |
| title_short | Association Between Glycation Gap and Renal Complications in People with Type 2 Diabetes |
| title_sort | association between glycation gap and renal complications in people with type 2 diabetes |
| topic | glycosylation gap glycated hemoglobin diabetes mellitus chronic kidney disease fructosamine |
| url | https://journals.viamedica.pl/clinical_diabetology/article/view/104794 |
| work_keys_str_mv | AT anwarjamal associationbetweenglycationgapandrenalcomplicationsinpeoplewithtype2diabetes AT asismitra associationbetweenglycationgapandrenalcomplicationsinpeoplewithtype2diabetes |