The Application of Organoid Technology in the Research of Central Nervous System Tumors
In recent years, organoid technology has emerged as a pivotal tool in central nervous system (CNS) tumor research. By recapitulating the 3D architecture, molecular profiles, and dynamic interactions of tumors with their microenvironment, it provides an innovative platform for elucidating disease mec...
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| Format: | Article |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2025-07-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2025-0065 |
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| author | WANG Zicong ZHAO Yahui YUAN Kexin ZHAO Yuanli |
| author_facet | WANG Zicong ZHAO Yahui YUAN Kexin ZHAO Yuanli |
| author_sort | WANG Zicong |
| collection | DOAJ |
| description | In recent years, organoid technology has emerged as a pivotal tool in central nervous system (CNS) tumor research. By recapitulating the 3D architecture, molecular profiles, and dynamic interactions of tumors with their microenvironment, it provides an innovative platform for elucidating disease mechanisms and facilitating drug screening. Brain organoids are primarily utilized to model normal neurodevelopmental processes and investigate CNS disease pathogenesis, whereas CNS tumor organoids are chiefly employed to simulate tumor heterogeneity and therapeutic responses. This review delineates the methodologies for establishing brain organoids and CNS tumor organoid models, along with their applications in CNS oncology research, with particular emphasis on the technical features and advantages of pluripotent stem cell-derived, patient-derived, and xenograft-derived organoid models. Furthermore, it examines current challenges in model standardization, microenvironment recapitulation, and ethical considerations pertaining to human tissue sources. Future directions for advancing this technology are also discussed. |
| format | Article |
| id | doaj-art-6a961cd4b92c4ef6adb804c4fca3198e |
| institution | Kabale University |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-6a961cd4b92c4ef6adb804c4fca3198e2025-08-20T04:00:28ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812025-07-0116483684610.12290/xhyxzz.2025-0065The Application of Organoid Technology in the Research of Central Nervous System TumorsWANG ZicongZHAO Yahui0YUAN Kexin1ZHAO Yuanli2Neurosurgery Center, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaIn recent years, organoid technology has emerged as a pivotal tool in central nervous system (CNS) tumor research. By recapitulating the 3D architecture, molecular profiles, and dynamic interactions of tumors with their microenvironment, it provides an innovative platform for elucidating disease mechanisms and facilitating drug screening. Brain organoids are primarily utilized to model normal neurodevelopmental processes and investigate CNS disease pathogenesis, whereas CNS tumor organoids are chiefly employed to simulate tumor heterogeneity and therapeutic responses. This review delineates the methodologies for establishing brain organoids and CNS tumor organoid models, along with their applications in CNS oncology research, with particular emphasis on the technical features and advantages of pluripotent stem cell-derived, patient-derived, and xenograft-derived organoid models. Furthermore, it examines current challenges in model standardization, microenvironment recapitulation, and ethical considerations pertaining to human tissue sources. Future directions for advancing this technology are also discussed.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2025-0065organoid technologycentral nervous system tumorspathogenesisdrug screening |
| spellingShingle | WANG Zicong ZHAO Yahui YUAN Kexin ZHAO Yuanli The Application of Organoid Technology in the Research of Central Nervous System Tumors Xiehe Yixue Zazhi organoid technology central nervous system tumors pathogenesis drug screening |
| title | The Application of Organoid Technology in the Research of Central Nervous System Tumors |
| title_full | The Application of Organoid Technology in the Research of Central Nervous System Tumors |
| title_fullStr | The Application of Organoid Technology in the Research of Central Nervous System Tumors |
| title_full_unstemmed | The Application of Organoid Technology in the Research of Central Nervous System Tumors |
| title_short | The Application of Organoid Technology in the Research of Central Nervous System Tumors |
| title_sort | application of organoid technology in the research of central nervous system tumors |
| topic | organoid technology central nervous system tumors pathogenesis drug screening |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2025-0065 |
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