Spinal ultrasound imaging implied the vascular dynamics in chronic and acute pain
Neurovascular coupling links local neural activity to cerebral blood flow changes, crucial for pain transduction. In this undertaking, we present an advanced spinal functional ultrasound imaging that exhibits precise observation capabilities of the influence of analgesic medications on spinal cord b...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | MethodsX |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215016125001190 |
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| author | Yingzhuo Ding Chunxia Yu Qingqing Chi Mengjiao Deng Dongxia Duan Jinbao Wei Yufei Xi Qin Li Le Ma |
| author_facet | Yingzhuo Ding Chunxia Yu Qingqing Chi Mengjiao Deng Dongxia Duan Jinbao Wei Yufei Xi Qin Li Le Ma |
| author_sort | Yingzhuo Ding |
| collection | DOAJ |
| description | Neurovascular coupling links local neural activity to cerebral blood flow changes, crucial for pain transduction. In this undertaking, we present an advanced spinal functional ultrasound imaging that exhibits precise observation capabilities of the influence of analgesic medications on spinal cord blood flow, encompassing both acute and chronic pain scenarios. Utilizing gabapentin as the primary analgesic agent, we have observed that intrathecal administration of gabapentin notably augments the blood flow intensity in neuropathic rats while exerting minimal influence on the blood flow of the sham rats. Furthermore, subcutaneous formalin injection increases spinal cord blood flow, but gabapentin pretreatment prevents those effects. These findings demonstrated the analgesic effect of gabapentin exhibits a synergistic interaction with the intensity of blood flow around neurons, which is crucial for understanding the mechanisms underlying the occurrence of pain. In this article, we show:• A simple method to build the spinal cord ligation-induced chronic pain model.• A generic way to build the formalin-induced acute pain model.• An optimized functional ultrasound imaging technique in chronic and acute pain. |
| format | Article |
| id | doaj-art-6a9225eaa2ed48cab67a78d5ad3b018b |
| institution | Kabale University |
| issn | 2215-0161 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | MethodsX |
| spelling | doaj-art-6a9225eaa2ed48cab67a78d5ad3b018b2025-08-20T03:30:29ZengElsevierMethodsX2215-01612025-06-011410327310.1016/j.mex.2025.103273Spinal ultrasound imaging implied the vascular dynamics in chronic and acute painYingzhuo Ding0Chunxia Yu1Qingqing Chi2Mengjiao Deng3Dongxia Duan4Jinbao Wei5Yufei Xi6Qin Li7Le Ma8Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongji University, National Clinical Research Center for Eye Diseases, Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, NO.1440 Hongqiao Road, 200336 Shanghai, ChinaShanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongji University, National Clinical Research Center for Eye Diseases, Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, NO.1440 Hongqiao Road, 200336 Shanghai, ChinaShanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongji University, National Clinical Research Center for Eye Diseases, Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, NO.1440 Hongqiao Road, 200336 Shanghai, ChinaShanghai Pulmonary Hospital, Tongji University of Medicine, 507 Zhengmin Road, 200433 Shanghai, ChinaShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 201108 Shanghai, ChinaDepartment of Pharmacy, Xiamen Haicang Hospital, 361026 Xiamen, ChinaShanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongji University, National Clinical Research Center for Eye Diseases, Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, NO.1440 Hongqiao Road, 200336 Shanghai, China; Corresponding authors.Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongji University, National Clinical Research Center for Eye Diseases, Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, NO.1440 Hongqiao Road, 200336 Shanghai, China; Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, 200080 Shanghai, PR China; Corresponding author at: Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, 200080 Shanghai, PR China.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 201108 Shanghai, China; Corresponding authors.Neurovascular coupling links local neural activity to cerebral blood flow changes, crucial for pain transduction. In this undertaking, we present an advanced spinal functional ultrasound imaging that exhibits precise observation capabilities of the influence of analgesic medications on spinal cord blood flow, encompassing both acute and chronic pain scenarios. Utilizing gabapentin as the primary analgesic agent, we have observed that intrathecal administration of gabapentin notably augments the blood flow intensity in neuropathic rats while exerting minimal influence on the blood flow of the sham rats. Furthermore, subcutaneous formalin injection increases spinal cord blood flow, but gabapentin pretreatment prevents those effects. These findings demonstrated the analgesic effect of gabapentin exhibits a synergistic interaction with the intensity of blood flow around neurons, which is crucial for understanding the mechanisms underlying the occurrence of pain. In this article, we show:• A simple method to build the spinal cord ligation-induced chronic pain model.• A generic way to build the formalin-induced acute pain model.• An optimized functional ultrasound imaging technique in chronic and acute pain.http://www.sciencedirect.com/science/article/pii/S2215016125001190spinal functional ultrasound imaging |
| spellingShingle | Yingzhuo Ding Chunxia Yu Qingqing Chi Mengjiao Deng Dongxia Duan Jinbao Wei Yufei Xi Qin Li Le Ma Spinal ultrasound imaging implied the vascular dynamics in chronic and acute pain MethodsX spinal functional ultrasound imaging |
| title | Spinal ultrasound imaging implied the vascular dynamics in chronic and acute pain |
| title_full | Spinal ultrasound imaging implied the vascular dynamics in chronic and acute pain |
| title_fullStr | Spinal ultrasound imaging implied the vascular dynamics in chronic and acute pain |
| title_full_unstemmed | Spinal ultrasound imaging implied the vascular dynamics in chronic and acute pain |
| title_short | Spinal ultrasound imaging implied the vascular dynamics in chronic and acute pain |
| title_sort | spinal ultrasound imaging implied the vascular dynamics in chronic and acute pain |
| topic | spinal functional ultrasound imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2215016125001190 |
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