Screening of Potential Antibiotics, Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis (2-C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Derivatives)
The recently discovered nonmevalonate pathway of isoprenoid biosynthesis Is a prospective target in screening of new antibiotics. Because of the absence of the pathway in the animal cells, the specific inhibitors of the pathway will be a new class of antibiotics against many pathogens (which cause e...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/303 |
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| author | YU. V. Ershov K. V. Mazikin D. N. Ostrovsky |
| author_facet | YU. V. Ershov K. V. Mazikin D. N. Ostrovsky |
| author_sort | YU. V. Ershov |
| collection | DOAJ |
| description | The recently discovered nonmevalonate pathway of isoprenoid biosynthesis Is a prospective target in screening of new antibiotics. Because of the absence of the pathway in the animal cells, the specific inhibitors of the pathway will be a new class of antibiotics against many pathogens (which cause e.g. malaria, tuberculosis, etc), combining high efficiency and low toxicity. Several derivatives of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate (MEC) were synthesized. 4-Phospho-methyl-D-erythritol-1,2-cyclophosphate, benzyl ether and benzyliden derivative of MEC inhibited the14C-MEC incorporation into isoprenoids of chromoplasts from red pepper with IC50 of 1.7-5 мМ. Some inhibition (about 10 %) was also observed with the use of dimethyl ether and isopropyliden derivative of MEC. |
| format | Article |
| id | doaj-art-6a90ff74fc6543818f8592d612e2a4e6 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-6a90ff74fc6543818f8592d612e2a4e62025-08-20T03:20:37ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01555-637302Screening of Potential Antibiotics, Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis (2-C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Derivatives)YU. V. Ershov0K. V. Mazikin1D. N. Ostrovsky2A. N. Bakh Institute of BiochemistryA. N. Bakh Institute of BiochemistryA. N. Bakh Institute of BiochemistryThe recently discovered nonmevalonate pathway of isoprenoid biosynthesis Is a prospective target in screening of new antibiotics. Because of the absence of the pathway in the animal cells, the specific inhibitors of the pathway will be a new class of antibiotics against many pathogens (which cause e.g. malaria, tuberculosis, etc), combining high efficiency and low toxicity. Several derivatives of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate (MEC) were synthesized. 4-Phospho-methyl-D-erythritol-1,2-cyclophosphate, benzyl ether and benzyliden derivative of MEC inhibited the14C-MEC incorporation into isoprenoids of chromoplasts from red pepper with IC50 of 1.7-5 мМ. Some inhibition (about 10 %) was also observed with the use of dimethyl ether and isopropyliden derivative of MEC.https://www.antibiotics-chemotherapy.ru/jour/article/view/303antibiotics screeningisoprenoid biosynthesis inhibitors |
| spellingShingle | YU. V. Ershov K. V. Mazikin D. N. Ostrovsky Screening of Potential Antibiotics, Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis (2-C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Derivatives) Антибиотики и Химиотерапия antibiotics screening isoprenoid biosynthesis inhibitors |
| title | Screening of Potential Antibiotics, Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis (2-C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Derivatives) |
| title_full | Screening of Potential Antibiotics, Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis (2-C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Derivatives) |
| title_fullStr | Screening of Potential Antibiotics, Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis (2-C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Derivatives) |
| title_full_unstemmed | Screening of Potential Antibiotics, Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis (2-C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Derivatives) |
| title_short | Screening of Potential Antibiotics, Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis (2-C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Derivatives) |
| title_sort | screening of potential antibiotics inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis 2 c methyl d erythritol 2 4 cyclodiphosphate derivatives |
| topic | antibiotics screening isoprenoid biosynthesis inhibitors |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/303 |
| work_keys_str_mv | AT yuvershov screeningofpotentialantibioticsinhibitorsofthenonmevalonatepathwayofisoprenoidbiosynthesis2cmethylderythritol24cyclodiphosphatederivatives AT kvmazikin screeningofpotentialantibioticsinhibitorsofthenonmevalonatepathwayofisoprenoidbiosynthesis2cmethylderythritol24cyclodiphosphatederivatives AT dnostrovsky screeningofpotentialantibioticsinhibitorsofthenonmevalonatepathwayofisoprenoidbiosynthesis2cmethylderythritol24cyclodiphosphatederivatives |