Screening of Potential Antibiotics, Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis (2-C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Derivatives)
The recently discovered nonmevalonate pathway of isoprenoid biosynthesis Is a prospective target in screening of new antibiotics. Because of the absence of the pathway in the animal cells, the specific inhibitors of the pathway will be a new class of antibiotics against many pathogens (which cause e...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/303 |
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| Summary: | The recently discovered nonmevalonate pathway of isoprenoid biosynthesis Is a prospective target in screening of new antibiotics. Because of the absence of the pathway in the animal cells, the specific inhibitors of the pathway will be a new class of antibiotics against many pathogens (which cause e.g. malaria, tuberculosis, etc), combining high efficiency and low toxicity. Several derivatives of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate (MEC) were synthesized. 4-Phospho-methyl-D-erythritol-1,2-cyclophosphate, benzyl ether and benzyliden derivative of MEC inhibited the14C-MEC incorporation into isoprenoids of chromoplasts from red pepper with IC50 of 1.7-5 мМ. Some inhibition (about 10 %) was also observed with the use of dimethyl ether and isopropyliden derivative of MEC. |
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| ISSN: | 0235-2990 |