A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma
ObjectiveGastric cancer is a serious human chronic disease. The gastric signet ring cell carcinoma (GSRCC) is the most-dangerous subtype with several acute complications, including gastrointestinal hemorrhage, gastric perforation, pyloric obstruction and so on. This study aimed to compare the predic...
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Frontiers Media S.A.
2025-05-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1600626/full |
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| author | Cenzhu Wang Ying Fang Yuhan Zhang Shuhan Feng Rui Hou Hanfang Fan Zeyu Wang Lei Liu Junli Ding Junying Xu |
| author_facet | Cenzhu Wang Ying Fang Yuhan Zhang Shuhan Feng Rui Hou Hanfang Fan Zeyu Wang Lei Liu Junli Ding Junying Xu |
| author_sort | Cenzhu Wang |
| collection | DOAJ |
| description | ObjectiveGastric cancer is a serious human chronic disease. The gastric signet ring cell carcinoma (GSRCC) is the most-dangerous subtype with several acute complications, including gastrointestinal hemorrhage, gastric perforation, pyloric obstruction and so on. This study aimed to compare the predictive efficiency of positive lymph nodes (PLN) and log odds of positive lymph nodes (LODDS) for survival and to establish a LODDS-based nomogram model in stage III-IV GSRCC.MethodsStage III-IV GSRCC patients were acquired between 2015 and 2019 from SEER dataset and the affiliated Yixing hospital of jiangsu university, serving as training and validation datasets respectively. The X-tile software was used to identify cut-off values while their relationship with clinical features was explored by chi-square test. The Kaplan-Meier analysis was applied for survival curve while cox regression analysis was performed for independent risk factors. The nomogram model was built with ROC and calibration curves for verification.ResultsA total of 585 stage III-IV GSRCC patients were included in this study with 536 patients for training and 49 patients for validation. The LODDS showed better predictive efficiency for overall survival (OS) and cancer-specific survival (CSS) than PLN. The LODDS, M stage and chemotherapy status were independent factors for both OS and CSS, with LODDS contribution accounting for 31.47% in OS and 30.39% in CSS. A LODDS-based nomogram was built with accurate efficiency in stage III-IV GSRCC. The 1-year, 2-year, 3-year OS area under curve (AUC) values were 0.755, 0.795, 0.759 for internal and 0.776, 0.756, 0.816 for external verification while 1-year, 2-year, 3-year CSS AUC values were 0.745, 0.803, 0.770 for internal and 0.796, 0.762, 0.820 for external verification.ConclusionLODDS is an independent risk factor in stage III-IV GSRCC. The LODDS-based nomogram model showed excellent predictive efficiency, providing a novel insight for early diagnosis and precise therapies of stage III-IV GSRCC. |
| format | Article |
| id | doaj-art-6a8efb93683b4b34b4cc8df0b4a353ab |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-6a8efb93683b4b34b4cc8df0b4a353ab2025-08-20T01:49:27ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-05-011210.3389/fmolb.2025.16006261600626A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinomaCenzhu Wang0Ying Fang1Yuhan Zhang2Shuhan Feng3Rui Hou4Hanfang Fan5Zeyu Wang6Lei Liu7Junli Ding8Junying Xu9Department of Oncology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Chemotherapy, Jiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Institute of Cancer Research, Nanjing, ChinaDepartment of Oncology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Gastroenterology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, ChinaDepartment of Oncology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Oncology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Oncology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Gastroenterology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, ChinaDepartment of Oncology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Oncology, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaObjectiveGastric cancer is a serious human chronic disease. The gastric signet ring cell carcinoma (GSRCC) is the most-dangerous subtype with several acute complications, including gastrointestinal hemorrhage, gastric perforation, pyloric obstruction and so on. This study aimed to compare the predictive efficiency of positive lymph nodes (PLN) and log odds of positive lymph nodes (LODDS) for survival and to establish a LODDS-based nomogram model in stage III-IV GSRCC.MethodsStage III-IV GSRCC patients were acquired between 2015 and 2019 from SEER dataset and the affiliated Yixing hospital of jiangsu university, serving as training and validation datasets respectively. The X-tile software was used to identify cut-off values while their relationship with clinical features was explored by chi-square test. The Kaplan-Meier analysis was applied for survival curve while cox regression analysis was performed for independent risk factors. The nomogram model was built with ROC and calibration curves for verification.ResultsA total of 585 stage III-IV GSRCC patients were included in this study with 536 patients for training and 49 patients for validation. The LODDS showed better predictive efficiency for overall survival (OS) and cancer-specific survival (CSS) than PLN. The LODDS, M stage and chemotherapy status were independent factors for both OS and CSS, with LODDS contribution accounting for 31.47% in OS and 30.39% in CSS. A LODDS-based nomogram was built with accurate efficiency in stage III-IV GSRCC. The 1-year, 2-year, 3-year OS area under curve (AUC) values were 0.755, 0.795, 0.759 for internal and 0.776, 0.756, 0.816 for external verification while 1-year, 2-year, 3-year CSS AUC values were 0.745, 0.803, 0.770 for internal and 0.796, 0.762, 0.820 for external verification.ConclusionLODDS is an independent risk factor in stage III-IV GSRCC. The LODDS-based nomogram model showed excellent predictive efficiency, providing a novel insight for early diagnosis and precise therapies of stage III-IV GSRCC.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1600626/fullGSRCCstage III-IVPLNLODDSnomogram |
| spellingShingle | Cenzhu Wang Ying Fang Yuhan Zhang Shuhan Feng Rui Hou Hanfang Fan Zeyu Wang Lei Liu Junli Ding Junying Xu A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma Frontiers in Molecular Biosciences GSRCC stage III-IV PLN LODDS nomogram |
| title | A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma |
| title_full | A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma |
| title_fullStr | A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma |
| title_full_unstemmed | A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma |
| title_short | A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma |
| title_sort | lodds based nomogram for overall and cancer specific survival in stage iii iv gastric signet ring cell carcinoma |
| topic | GSRCC stage III-IV PLN LODDS nomogram |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1600626/full |
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