Inhaled nitric oxide in adult patients with acute respiratory distress syndrome
p>In some patients, acute respiratory distress syndrome (ARDS) leads to life-threatening refractory hypoxemia developing. Physicians may consider hypoxemic rescue therapies in an attempt to improve oxygenation in these patients while on conventional mechanical ventilation support. Use of inhaled...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-03-01
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| Series: | Farmacia Hospitalaria |
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| Online Access: | http://www.aulamedica.es/fh/pdf/10533.pdf |
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| author | José Ángel Monsalve-Naharro Esther Domingo-Chiva Sergio García Castillo Pablo Cuesta-Montero José María Jiménez-Vizuete |
| author_facet | José Ángel Monsalve-Naharro Esther Domingo-Chiva Sergio García Castillo Pablo Cuesta-Montero José María Jiménez-Vizuete |
| author_sort | José Ángel Monsalve-Naharro |
| collection | DOAJ |
| description | p>In some patients, acute respiratory distress syndrome (ARDS) leads to life-threatening refractory hypoxemia developing. Physicians may consider hypoxemic rescue therapies in an attempt to improve oxygenation in these patients while on conventional mechanical ventilation support. Use of inhaled nitric oxide (iNO) in ARDS is one of the most widely-studied pharmacological interventions over the past two decades. Its efficacy was examined in several randomized clinical trials and has undergone meta-analyses. Although iNO treatment was associated with improved oxygenation, researchers unfortunately never demonstrated a concomitant decrease in mortality or any improved outcome. Hence the current evidence suggests that iNO should not be routinely used in patients with ARDS however may be considered as adjunct therapy to tentatively improve oxygenation while other therapies are being considered in patients with severely hypoxemic ARDS.<br />This review focuses on the therapeutic use of iNO in adult ARDS patients. We set out some recommendations for its use as rescue therapy against refractory hypoxemia.</p> |
| format | Article |
| id | doaj-art-6a8bf8e8d9ad4d35b866db6bae79c1ca |
| institution | Kabale University |
| issn | 1130-6343 2171-8695 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Farmacia Hospitalaria |
| spelling | doaj-art-6a8bf8e8d9ad4d35b866db6bae79c1ca2025-01-02T16:49:00ZengElsevierFarmacia Hospitalaria1130-63432171-86952017-03-0141229231310.7399/fh.2017.41.2.10533Inhaled nitric oxide in adult patients with acute respiratory distress syndromeJosé Ángel Monsalve-Naharro0Esther Domingo-Chiva1Sergio García Castillo2Pablo Cuesta-Montero3José María Jiménez-Vizuete4Anesthesiology and Recovery Department. Albacete University Hospital Complex. Integrated Healthcare Management Office for Albacete. Calle Hermanos Falcó 37, Albacete.Hospital Pharmacy Department. Albacete University Hospital Complex. Integrated Healthcare Management Office for Albacete. Calle Hermanos Falcó 37, AlbacetePulmonology Department. Albacete University Hospital Complex. Integrated Healthcare Management Office for Albacete. Calle Hermanos Falcó 37, Albacete.Anesthesiology and Recovery Department. Albacete University Hospital Complex. Integrated Healthcare Management Office for Albacete. Calle Hermanos Falcó 37, AlbaceteAnesthesiology and Recovery Department. Albacete University Hospital Complex. Integrated Healthcare Management Office for Albacete. Calle Hermanos Falcó 37, Albacetep>In some patients, acute respiratory distress syndrome (ARDS) leads to life-threatening refractory hypoxemia developing. Physicians may consider hypoxemic rescue therapies in an attempt to improve oxygenation in these patients while on conventional mechanical ventilation support. Use of inhaled nitric oxide (iNO) in ARDS is one of the most widely-studied pharmacological interventions over the past two decades. Its efficacy was examined in several randomized clinical trials and has undergone meta-analyses. Although iNO treatment was associated with improved oxygenation, researchers unfortunately never demonstrated a concomitant decrease in mortality or any improved outcome. Hence the current evidence suggests that iNO should not be routinely used in patients with ARDS however may be considered as adjunct therapy to tentatively improve oxygenation while other therapies are being considered in patients with severely hypoxemic ARDS.<br />This review focuses on the therapeutic use of iNO in adult ARDS patients. We set out some recommendations for its use as rescue therapy against refractory hypoxemia.</p>http://www.aulamedica.es/fh/pdf/10533.pdfAcute respiratory distress syndromeAcute lung injury; HypoxemiaNitric oxide |
| spellingShingle | José Ángel Monsalve-Naharro Esther Domingo-Chiva Sergio García Castillo Pablo Cuesta-Montero José María Jiménez-Vizuete Inhaled nitric oxide in adult patients with acute respiratory distress syndrome Farmacia Hospitalaria Acute respiratory distress syndrome Acute lung injury ; Hypoxemia Nitric oxide |
| title | Inhaled nitric oxide in adult patients with acute respiratory distress syndrome |
| title_full | Inhaled nitric oxide in adult patients with acute respiratory distress syndrome |
| title_fullStr | Inhaled nitric oxide in adult patients with acute respiratory distress syndrome |
| title_full_unstemmed | Inhaled nitric oxide in adult patients with acute respiratory distress syndrome |
| title_short | Inhaled nitric oxide in adult patients with acute respiratory distress syndrome |
| title_sort | inhaled nitric oxide in adult patients with acute respiratory distress syndrome |
| topic | Acute respiratory distress syndrome Acute lung injury ; Hypoxemia Nitric oxide |
| url | http://www.aulamedica.es/fh/pdf/10533.pdf |
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