Age-related decline in retinal function in marmosets
Abstract Vision deterioration caused by natural aging have a detrimental impact on an individual’s quality of life, which has become a serious problem as the world’s population is aging rapidly. Rodents are the commonly used animal species to investigate the physiological aging process or to identif...
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-05262-z |
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| author | Takahiko Noro Xiaoli Guo Rika Kikuchi Kenya Sato Kazuhiko Namekata Youichi Shinozaki Chikako Harada Terumi Yurimoto Nanako Hashimoto Keiko Moriya-Ito Tadashi Nakano Erika Sasaki Takayuki Harada |
| author_facet | Takahiko Noro Xiaoli Guo Rika Kikuchi Kenya Sato Kazuhiko Namekata Youichi Shinozaki Chikako Harada Terumi Yurimoto Nanako Hashimoto Keiko Moriya-Ito Tadashi Nakano Erika Sasaki Takayuki Harada |
| author_sort | Takahiko Noro |
| collection | DOAJ |
| description | Abstract Vision deterioration caused by natural aging have a detrimental impact on an individual’s quality of life, which has become a serious problem as the world’s population is aging rapidly. Rodents are the commonly used animal species to investigate the physiological aging process or to identify possible therapeutic targets. However, due to anatomical differences and their genetic distance to humans, translation of findings is sometimes complicated. In the present study, as a step toward aging study in vision using non-human primate marmosets, we examined the eyes of aged marmosets non-invasively. We found that the retinal response deteriorated along with the retinal structure in aged marmosets and the retinal peripheral region was more susceptible to aging. Moreover, the expression of the oxidative stress biomarker 4-HNE was increased in the serum of aged marmosets although no significant correlation was found between 4-HNE levels and the retinal thickness. Our study demonstrated that marmosets offer a promising translational model for the research of age-related vision declination. |
| format | Article |
| id | doaj-art-6a898f425f02435d991a92b35c616804 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6a898f425f02435d991a92b35c6168042025-08-20T03:45:28ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-05262-zAge-related decline in retinal function in marmosetsTakahiko Noro0Xiaoli Guo1Rika Kikuchi2Kenya Sato3Kazuhiko Namekata4Youichi Shinozaki5Chikako Harada6Terumi Yurimoto7Nanako Hashimoto8Keiko Moriya-Ito9Tadashi Nakano10Erika Sasaki11Takayuki Harada12Visual Research Project, Tokyo Metropolitan Institute of Medical ScienceVisual Research Project, Tokyo Metropolitan Institute of Medical ScienceCentral Institute for Experimental Medicine and Life ScienceCentral Institute for Experimental Medicine and Life ScienceVisual Research Project, Tokyo Metropolitan Institute of Medical ScienceVisual Research Project, Tokyo Metropolitan Institute of Medical ScienceVisual Research Project, Tokyo Metropolitan Institute of Medical ScienceCentral Institute for Experimental Medicine and Life ScienceCenter for Basic Technology Research, Tokyo Metropolitan Institute of Medical ScienceDevelopmental Neuroscience Project, Tokyo Metropolitan Institute of Medical ScienceDepartment of Ophthalmology, The Jikei University School of MedicineCentral Institute for Experimental Medicine and Life ScienceVisual Research Project, Tokyo Metropolitan Institute of Medical ScienceAbstract Vision deterioration caused by natural aging have a detrimental impact on an individual’s quality of life, which has become a serious problem as the world’s population is aging rapidly. Rodents are the commonly used animal species to investigate the physiological aging process or to identify possible therapeutic targets. However, due to anatomical differences and their genetic distance to humans, translation of findings is sometimes complicated. In the present study, as a step toward aging study in vision using non-human primate marmosets, we examined the eyes of aged marmosets non-invasively. We found that the retinal response deteriorated along with the retinal structure in aged marmosets and the retinal peripheral region was more susceptible to aging. Moreover, the expression of the oxidative stress biomarker 4-HNE was increased in the serum of aged marmosets although no significant correlation was found between 4-HNE levels and the retinal thickness. Our study demonstrated that marmosets offer a promising translational model for the research of age-related vision declination.https://doi.org/10.1038/s41598-025-05262-zAge-related retinal degenerationOxidative stressMarmosets |
| spellingShingle | Takahiko Noro Xiaoli Guo Rika Kikuchi Kenya Sato Kazuhiko Namekata Youichi Shinozaki Chikako Harada Terumi Yurimoto Nanako Hashimoto Keiko Moriya-Ito Tadashi Nakano Erika Sasaki Takayuki Harada Age-related decline in retinal function in marmosets Scientific Reports Age-related retinal degeneration Oxidative stress Marmosets |
| title | Age-related decline in retinal function in marmosets |
| title_full | Age-related decline in retinal function in marmosets |
| title_fullStr | Age-related decline in retinal function in marmosets |
| title_full_unstemmed | Age-related decline in retinal function in marmosets |
| title_short | Age-related decline in retinal function in marmosets |
| title_sort | age related decline in retinal function in marmosets |
| topic | Age-related retinal degeneration Oxidative stress Marmosets |
| url | https://doi.org/10.1038/s41598-025-05262-z |
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