Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting‐State fMRI Study
ABSTRACT Objective This study utilized functional magnetic resonance imaging (fMRI) data to investigate cognitive function changes in trigeminal neuralgia (TN) patients and healthy controls (HCs), and to elucidate the potential mechanism. Materials and Methods The cognitive function of 34 patients w...
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Wiley
2025-03-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70434 |
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| author | Xueyun Deng Lihua Liu Jiafei Chen Zhi Liu Hua Feng |
| author_facet | Xueyun Deng Lihua Liu Jiafei Chen Zhi Liu Hua Feng |
| author_sort | Xueyun Deng |
| collection | DOAJ |
| description | ABSTRACT Objective This study utilized functional magnetic resonance imaging (fMRI) data to investigate cognitive function changes in trigeminal neuralgia (TN) patients and healthy controls (HCs), and to elucidate the potential mechanism. Materials and Methods The cognitive function of 34 patients with TN and 30 HCs was evaluated. Afterward, we calculated the amplitude of low‐frequency fluctuations (ALFFs), regional homogeneity (ReHo), and degree centrality (DC). These metrics were correlated with cognitive performance using the Spearman correlation analysis. Results Patients with TN exhibited diminished cognitive performance compared to HCs. Increased mean ALFF (mALFF) levels were detected in the right temporal pole, superior temporal gyrus, and right insula in individuals with TN. These increases were negatively correlated with cognitive function. In contrast, decreased mALFF values were observed in the right lingual gyrus, bilateral calcarine, and left middle occipital gyrus, which were associated with improved cognitive function. Increased DC values were found in various areas, such as the right temporal pole, superior temporal gyrus, right opercular inferior frontal gyrus, bilateral medial superior frontal gyrus, left supplementary motor area, left anterior cingulum, and right middle cingulum in individuals with TN. These values negatively correlated with cognitive performance. Conclusion TN patients exhibited impairments in multiple cognitive areas, such as attention, memory, executive function, visual perception and executive ability, information processing speed, and motor speed. The metrics ALFF and DC exhibited alterations in TN patients, suggesting that cognitive impairments may be linked to decreased functional activity in specific brain regions. Concurrently, certain cerebral regions may exhibit increased functional activity as a compensatory response to cognitive deficits. These findings hold significant theoretical value and clinical application potential, providing novel methodologies and perspectives for early diagnosis, personalized treatment, and efficacy evaluation. Such advancements are poised to enhance the overall treatment outcomes and quality of life for TN patients. |
| format | Article |
| id | doaj-art-6a8575cd8a124143863fb3f6d820bebb |
| institution | DOAJ |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-6a8575cd8a124143863fb3f6d820bebb2025-08-20T03:05:14ZengWileyBrain and Behavior2162-32792025-03-01153n/an/a10.1002/brb3.70434Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting‐State fMRI StudyXueyun Deng0Lihua Liu1Jiafei Chen2Zhi Liu3Hua Feng4Department of Neurosurgery Southwest Hospital, Army Medical University Chongqing ChinaDepartment of Geriatrics Sichuan Provincial People's Hospital Eastern Sichuan Hospital & Dazhou First People's Hospital Dazhou Sichuan ChinaDepartment of Radiology Southwest Hospital, Army Medical University Chongqing ChinaDepartment of Neurosurgery Southwest Hospital, Army Medical University Chongqing ChinaDepartment of Neurosurgery Southwest Hospital, Army Medical University Chongqing ChinaABSTRACT Objective This study utilized functional magnetic resonance imaging (fMRI) data to investigate cognitive function changes in trigeminal neuralgia (TN) patients and healthy controls (HCs), and to elucidate the potential mechanism. Materials and Methods The cognitive function of 34 patients with TN and 30 HCs was evaluated. Afterward, we calculated the amplitude of low‐frequency fluctuations (ALFFs), regional homogeneity (ReHo), and degree centrality (DC). These metrics were correlated with cognitive performance using the Spearman correlation analysis. Results Patients with TN exhibited diminished cognitive performance compared to HCs. Increased mean ALFF (mALFF) levels were detected in the right temporal pole, superior temporal gyrus, and right insula in individuals with TN. These increases were negatively correlated with cognitive function. In contrast, decreased mALFF values were observed in the right lingual gyrus, bilateral calcarine, and left middle occipital gyrus, which were associated with improved cognitive function. Increased DC values were found in various areas, such as the right temporal pole, superior temporal gyrus, right opercular inferior frontal gyrus, bilateral medial superior frontal gyrus, left supplementary motor area, left anterior cingulum, and right middle cingulum in individuals with TN. These values negatively correlated with cognitive performance. Conclusion TN patients exhibited impairments in multiple cognitive areas, such as attention, memory, executive function, visual perception and executive ability, information processing speed, and motor speed. The metrics ALFF and DC exhibited alterations in TN patients, suggesting that cognitive impairments may be linked to decreased functional activity in specific brain regions. Concurrently, certain cerebral regions may exhibit increased functional activity as a compensatory response to cognitive deficits. These findings hold significant theoretical value and clinical application potential, providing novel methodologies and perspectives for early diagnosis, personalized treatment, and efficacy evaluation. Such advancements are poised to enhance the overall treatment outcomes and quality of life for TN patients.https://doi.org/10.1002/brb3.70434cognitioncognitive declinecognitive functionresting‐state fMRItrigeminal neuralgia |
| spellingShingle | Xueyun Deng Lihua Liu Jiafei Chen Zhi Liu Hua Feng Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting‐State fMRI Study Brain and Behavior cognition cognitive decline cognitive function resting‐state fMRI trigeminal neuralgia |
| title | Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting‐State fMRI Study |
| title_full | Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting‐State fMRI Study |
| title_fullStr | Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting‐State fMRI Study |
| title_full_unstemmed | Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting‐State fMRI Study |
| title_short | Cognitive Decline in Patients With Trigeminal Neuralgia: A Resting‐State fMRI Study |
| title_sort | cognitive decline in patients with trigeminal neuralgia a resting state fmri study |
| topic | cognition cognitive decline cognitive function resting‐state fMRI trigeminal neuralgia |
| url | https://doi.org/10.1002/brb3.70434 |
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