Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021)
Hai Ha Long Le,1,2 Luong Cong Thuc,3 Thang Ba Ta,4 Tien Viet Tran,5 Dinh Viet Hung,6 Hoang Trung Kien,7 Minh Nhat Le,8,9 Vu Huy Luong,10,11 Vinh Thi Ha Nguyen,11,12 Hoa Quynh Pham,13 Hung Van Le,11,13 Nguyen Hoang Viet,14 Le Huy Hoang,15 Tram Thuy Nguyen,15 Mixay Latsavong,16 Tuan Dinh Le,17 Dao Tro...
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Dove Medical Press
2025-01-01
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| Series: | Infection and Drug Resistance |
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| author | Le HHL Thuc LC Ta TB Tran TV Hung DV Kien HT Le MN Luong VH Nguyen VTH Pham HQ Le HV Viet NH Hoang LH Nguyen TT Latsavong M Le TD Trong Tuan D An NV |
| author_facet | Le HHL Thuc LC Ta TB Tran TV Hung DV Kien HT Le MN Luong VH Nguyen VTH Pham HQ Le HV Viet NH Hoang LH Nguyen TT Latsavong M Le TD Trong Tuan D An NV |
| author_sort | Le HHL |
| collection | DOAJ |
| description | Hai Ha Long Le,1,2 Luong Cong Thuc,3 Thang Ba Ta,4 Tien Viet Tran,5 Dinh Viet Hung,6 Hoang Trung Kien,7 Minh Nhat Le,8,9 Vu Huy Luong,10,11 Vinh Thi Ha Nguyen,11,12 Hoa Quynh Pham,13 Hung Van Le,11,13 Nguyen Hoang Viet,14 Le Huy Hoang,15 Tram Thuy Nguyen,15 Mixay Latsavong,16 Tuan Dinh Le,17 Dao Trong Tuan,18 Nguyen Van An19 1Department of Clinical Microbiology and Parasitology, Faculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam; 2Department of Biochemistry, Hematology and Immunology, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 3Cardiovascular Center, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 4Respiratory Center, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 5Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 6Department of Psychiatry, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 7Department of Immunology, Vietnam Military Medical University, Hanoi, Vietnam; 8Tay Nguyen Institute of Science Research, Vietnam Academy of Science and Technology, VAST, Hanoi, Vietnam; 9Antimicrobial Resistance Research Center, National Institute of Infectious Disease, Tokyo, Japan; 10Department of Laser and Skincare, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 11Department of Dermatology and Venereology, Hanoi Medical University, Hanoi, Vietnam; 12Department of General Planning, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 13Department of Microbiology, Mycology and Parasitology, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 14Molecular Pathology Department, Faculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam; 15Department of Bacteriology, National of Hygiene and Epidemiology, Hanoi, Vietnam; 16Department of Nephrology-Hemodialysis, Military Central Hospital 103, Vientiane, Laos; 17Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 18ENT Department, Central Military Hospital 108, Hanoi, Vietnam; 19Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, VietnamCorrespondence: Nguyen Van An, Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, 100000, Vietnam, Tel + 84 982 860 055, Email ank59hvqy@gmail.comPurpose: In a Vietnamese teaching hospital, this study examined the prevalence and patterns of antimicrobial resistance (AMR) of common bacteria isolated from hospitalized patients with urinary tract infections (UTIs) between 2014 and 2021.Methods: From 4060 urine samples collected, common pathogens were isolated using quantitative culture on brilliance UTI Clarity agar and blood agar. Bacterial identification, antimicrobial susceptibility testing, and multidrug resistance (MDR) classification followed standardized techniques. Bacteria with a frequency of less than 2% were excluded. Statistical analysis was performed using R software, with the chi-square test applied and significance set at p < 0.05.Results: Of 4060 urine samples collected, 892 (22.0%) had positive results for common infections. Gram-negative bacteria predominated (591/892; 66.3%), with Escherichia coli being the most prevalent (336/892; 37.7%). Enterococcus spp. (152/892; 17.0%) was the leading Gram-positive pathogen. Some antibiotics had significant resistance rates, especially in Gram-negative bacteria, with ampicillin having the greatest resistance rate (92.8%). Carbapenems and nitrofurantoin remained generally effective. Among Gram-positive bacteria, high resistance was seen for macrolides ranging from 85.5% (azithromycin) to 89.8% (erythromycin), and for tetracyclines, ranging from 0% (teicoplanin) to 85.2% (tetracycline). There was no resistance to tigecycline and teicoplanin, indicating their potential efficacy against multidrug resistance (MDR) bacteria causing UTIs. MDR rates were higher in Gram-negative bacteria (64.8% versus 43.5%), with Klebsiella pneumoniae having the highest rate (78.7%).Conclusion: This study underscores the urgent need for ongoing surveillance of AMR patterns in Vietnam and emphasizes the significance of efficient infection prevention methods, prudent use of antibiotics, and targeted interventions to combat antimicrobial resistance.Keywords: urinary tract infections, UTIs, antimicrobial resistance, multidrug resistance, MDR, Vietnam |
| format | Article |
| id | doaj-art-6a83b945eba141208027c5642bc410c4 |
| institution | Kabale University |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj-art-6a83b945eba141208027c5642bc410c42025-01-30T18:07:17ZengDove Medical PressInfection and Drug Resistance1178-69732025-01-01Volume 1861362399748Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021)Le HHLThuc LCTa TBTran TVHung DVKien HTLe MNLuong VHNguyen VTHPham HQLe HVViet NHHoang LHNguyen TTLatsavong MLe TDTrong Tuan DAn NVHai Ha Long Le,1,2 Luong Cong Thuc,3 Thang Ba Ta,4 Tien Viet Tran,5 Dinh Viet Hung,6 Hoang Trung Kien,7 Minh Nhat Le,8,9 Vu Huy Luong,10,11 Vinh Thi Ha Nguyen,11,12 Hoa Quynh Pham,13 Hung Van Le,11,13 Nguyen Hoang Viet,14 Le Huy Hoang,15 Tram Thuy Nguyen,15 Mixay Latsavong,16 Tuan Dinh Le,17 Dao Trong Tuan,18 Nguyen Van An19 1Department of Clinical Microbiology and Parasitology, Faculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam; 2Department of Biochemistry, Hematology and Immunology, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 3Cardiovascular Center, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 4Respiratory Center, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 5Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 6Department of Psychiatry, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 7Department of Immunology, Vietnam Military Medical University, Hanoi, Vietnam; 8Tay Nguyen Institute of Science Research, Vietnam Academy of Science and Technology, VAST, Hanoi, Vietnam; 9Antimicrobial Resistance Research Center, National Institute of Infectious Disease, Tokyo, Japan; 10Department of Laser and Skincare, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 11Department of Dermatology and Venereology, Hanoi Medical University, Hanoi, Vietnam; 12Department of General Planning, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 13Department of Microbiology, Mycology and Parasitology, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 14Molecular Pathology Department, Faculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam; 15Department of Bacteriology, National of Hygiene and Epidemiology, Hanoi, Vietnam; 16Department of Nephrology-Hemodialysis, Military Central Hospital 103, Vientiane, Laos; 17Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 18ENT Department, Central Military Hospital 108, Hanoi, Vietnam; 19Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, VietnamCorrespondence: Nguyen Van An, Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, 100000, Vietnam, Tel + 84 982 860 055, Email ank59hvqy@gmail.comPurpose: In a Vietnamese teaching hospital, this study examined the prevalence and patterns of antimicrobial resistance (AMR) of common bacteria isolated from hospitalized patients with urinary tract infections (UTIs) between 2014 and 2021.Methods: From 4060 urine samples collected, common pathogens were isolated using quantitative culture on brilliance UTI Clarity agar and blood agar. Bacterial identification, antimicrobial susceptibility testing, and multidrug resistance (MDR) classification followed standardized techniques. Bacteria with a frequency of less than 2% were excluded. Statistical analysis was performed using R software, with the chi-square test applied and significance set at p < 0.05.Results: Of 4060 urine samples collected, 892 (22.0%) had positive results for common infections. Gram-negative bacteria predominated (591/892; 66.3%), with Escherichia coli being the most prevalent (336/892; 37.7%). Enterococcus spp. (152/892; 17.0%) was the leading Gram-positive pathogen. Some antibiotics had significant resistance rates, especially in Gram-negative bacteria, with ampicillin having the greatest resistance rate (92.8%). Carbapenems and nitrofurantoin remained generally effective. Among Gram-positive bacteria, high resistance was seen for macrolides ranging from 85.5% (azithromycin) to 89.8% (erythromycin), and for tetracyclines, ranging from 0% (teicoplanin) to 85.2% (tetracycline). There was no resistance to tigecycline and teicoplanin, indicating their potential efficacy against multidrug resistance (MDR) bacteria causing UTIs. MDR rates were higher in Gram-negative bacteria (64.8% versus 43.5%), with Klebsiella pneumoniae having the highest rate (78.7%).Conclusion: This study underscores the urgent need for ongoing surveillance of AMR patterns in Vietnam and emphasizes the significance of efficient infection prevention methods, prudent use of antibiotics, and targeted interventions to combat antimicrobial resistance.Keywords: urinary tract infections, UTIs, antimicrobial resistance, multidrug resistance, MDR, Vietnamhttps://www.dovepress.com/prevailing-antibiotic-resistance-patterns-in-hospitalized-patients-wit-peer-reviewed-fulltext-article-IDRurinary tract infectionsutisantimicrobial resistancemultidrug resistancemdrvietnam |
| spellingShingle | Le HHL Thuc LC Ta TB Tran TV Hung DV Kien HT Le MN Luong VH Nguyen VTH Pham HQ Le HV Viet NH Hoang LH Nguyen TT Latsavong M Le TD Trong Tuan D An NV Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021) Infection and Drug Resistance urinary tract infections utis antimicrobial resistance multidrug resistance mdr vietnam |
| title | Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021) |
| title_full | Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021) |
| title_fullStr | Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021) |
| title_full_unstemmed | Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021) |
| title_short | Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021) |
| title_sort | prevailing antibiotic resistance patterns in hospitalized patients with urinary tract infections in a vietnamese teaching hospital 2014 ndash 2021 |
| topic | urinary tract infections utis antimicrobial resistance multidrug resistance mdr vietnam |
| url | https://www.dovepress.com/prevailing-antibiotic-resistance-patterns-in-hospitalized-patients-wit-peer-reviewed-fulltext-article-IDR |
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