Development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices Risk Prediction Tool for Estimating Peri- and Postoperative Outcomes, Including Surgical Difficulty, in Major Urological Surgery—A Protocol for a Delphi Study
This protocol will outline the development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices (IPRADES), a tool designed to predict perioperative outcomes and surgical complexity in major urological procedures. Its objective will be to enhance preoperative planning and risk...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | European Urology Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666168325001089 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850103072868532224 |
|---|---|
| author | Christopher Soliman Patrick Y. Wuethrich Jochen Walz Niall M. Corcoran Nathan Lawrentschuk Anna Walde Marc A. Furrer |
| author_facet | Christopher Soliman Patrick Y. Wuethrich Jochen Walz Niall M. Corcoran Nathan Lawrentschuk Anna Walde Marc A. Furrer |
| author_sort | Christopher Soliman |
| collection | DOAJ |
| description | This protocol will outline the development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices (IPRADES), a tool designed to predict perioperative outcomes and surgical complexity in major urological procedures. Its objective will be to enhance preoperative planning and risk stratification by systematically evaluating a range of patient-, organ-, and surgery-specific factors. The study will be conducted in three phases. Firstly, expert consensus will be established through a Delphi survey involving experienced high-volume surgeons to identify key parameters influencing surgical difficulty and complications. Secondly, data will be collected from the CAMUS Collaboration database and augmented with additional parameters from a prospective open cystectomy database. Thirdly, using this extensive dataset, a nomogram will be developed to evaluate the association between the identified parameters and postoperative complications, as well as to quantify their predictive values. Each parameter will be assigned a weighted significance, which will be integrated into the final risk prediction model. Statistical analyses will incorporate multivariable regression models to identify predictors of complications and mortality. The model’s performance will be evaluated through c-statistics, Hosmer-Lemeshow tests, and Brier scores, with internal validation performed via dataset splitting and bootstrap resampling. Additionally, the study will compare the predictive accuracy of universal versus procedure-specific models. The tool will not only account for patient and surgical factors, but also incorporate the influence of surgeon experience and learning curves on surgical outcomes. A web-based calculator will be developed to facilitate seamless integration into daily clinical practice, providing real-time risk assessments. Following validation, the CAMUS IPRADES tool will refine surgical planning, optimise resource allocation, and enhance patient counselling. By delivering data-driven risk assessments, it will further enable surgeon and institutional benchmarking, thereby contributing to education, training, and clinical research. Ultimately, this tool will play a pivotal role in advancing the quality and safety of urological surgeries. |
| format | Article |
| id | doaj-art-6a7b985e4db3439f8cc6c8165c1fc353 |
| institution | DOAJ |
| issn | 2666-1683 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Urology Open Science |
| spelling | doaj-art-6a7b985e4db3439f8cc6c8165c1fc3532025-08-20T02:39:37ZengElsevierEuropean Urology Open Science2666-16832025-06-0176233710.1016/j.euros.2025.04.002Development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices Risk Prediction Tool for Estimating Peri- and Postoperative Outcomes, Including Surgical Difficulty, in Major Urological Surgery—A Protocol for a Delphi StudyChristopher Soliman0Patrick Y. Wuethrich1Jochen Walz2Niall M. Corcoran3Nathan Lawrentschuk4Anna Walde5Marc A. Furrer6Department of Urology, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, AustraliaDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Urology, Institut Paoli-Calmettes Cancer Centre, Marseille, FranceDepartment of Urology, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Urology, Western Health, Victoria, AustraliaDepartment of Urology, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, AustraliaDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Center for Space and Habitability, University of Bern, Bern, SwitzerlandDepartment of Urology, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Urology, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK; Department of Urology, Solothurner Spitäler AG, Kantonsspital Olten, and Bürgerspital Solothurn, University of Bern, Switzerland; Corresponding author. Department of Urology, Kantonsspital Olten, Baslerstrasse 150, 4600 Olten, Germany. Tel. +41 62 311 41 11.This protocol will outline the development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices (IPRADES), a tool designed to predict perioperative outcomes and surgical complexity in major urological procedures. Its objective will be to enhance preoperative planning and risk stratification by systematically evaluating a range of patient-, organ-, and surgery-specific factors. The study will be conducted in three phases. Firstly, expert consensus will be established through a Delphi survey involving experienced high-volume surgeons to identify key parameters influencing surgical difficulty and complications. Secondly, data will be collected from the CAMUS Collaboration database and augmented with additional parameters from a prospective open cystectomy database. Thirdly, using this extensive dataset, a nomogram will be developed to evaluate the association between the identified parameters and postoperative complications, as well as to quantify their predictive values. Each parameter will be assigned a weighted significance, which will be integrated into the final risk prediction model. Statistical analyses will incorporate multivariable regression models to identify predictors of complications and mortality. The model’s performance will be evaluated through c-statistics, Hosmer-Lemeshow tests, and Brier scores, with internal validation performed via dataset splitting and bootstrap resampling. Additionally, the study will compare the predictive accuracy of universal versus procedure-specific models. The tool will not only account for patient and surgical factors, but also incorporate the influence of surgeon experience and learning curves on surgical outcomes. A web-based calculator will be developed to facilitate seamless integration into daily clinical practice, providing real-time risk assessments. Following validation, the CAMUS IPRADES tool will refine surgical planning, optimise resource allocation, and enhance patient counselling. By delivering data-driven risk assessments, it will further enable surgeon and institutional benchmarking, thereby contributing to education, training, and clinical research. Ultimately, this tool will play a pivotal role in advancing the quality and safety of urological surgeries.http://www.sciencedirect.com/science/article/pii/S2666168325001089Risk stratificationSurgical difficultyUrological surgeriesDelphi methodConsensus paper |
| spellingShingle | Christopher Soliman Patrick Y. Wuethrich Jochen Walz Niall M. Corcoran Nathan Lawrentschuk Anna Walde Marc A. Furrer Development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices Risk Prediction Tool for Estimating Peri- and Postoperative Outcomes, Including Surgical Difficulty, in Major Urological Surgery—A Protocol for a Delphi Study European Urology Open Science Risk stratification Surgical difficulty Urological surgeries Delphi method Consensus paper |
| title | Development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices Risk Prediction Tool for Estimating Peri- and Postoperative Outcomes, Including Surgical Difficulty, in Major Urological Surgery—A Protocol for a Delphi Study |
| title_full | Development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices Risk Prediction Tool for Estimating Peri- and Postoperative Outcomes, Including Surgical Difficulty, in Major Urological Surgery—A Protocol for a Delphi Study |
| title_fullStr | Development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices Risk Prediction Tool for Estimating Peri- and Postoperative Outcomes, Including Surgical Difficulty, in Major Urological Surgery—A Protocol for a Delphi Study |
| title_full_unstemmed | Development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices Risk Prediction Tool for Estimating Peri- and Postoperative Outcomes, Including Surgical Difficulty, in Major Urological Surgery—A Protocol for a Delphi Study |
| title_short | Development of the CAMUS Intra- and Postoperative Risk and Difficulty Estimation Indices Risk Prediction Tool for Estimating Peri- and Postoperative Outcomes, Including Surgical Difficulty, in Major Urological Surgery—A Protocol for a Delphi Study |
| title_sort | development of the camus intra and postoperative risk and difficulty estimation indices risk prediction tool for estimating peri and postoperative outcomes including surgical difficulty in major urological surgery a protocol for a delphi study |
| topic | Risk stratification Surgical difficulty Urological surgeries Delphi method Consensus paper |
| url | http://www.sciencedirect.com/science/article/pii/S2666168325001089 |
| work_keys_str_mv | AT christophersoliman developmentofthecamusintraandpostoperativeriskanddifficultyestimationindicesriskpredictiontoolforestimatingperiandpostoperativeoutcomesincludingsurgicaldifficultyinmajorurologicalsurgeryaprotocolforadelphistudy AT patrickywuethrich developmentofthecamusintraandpostoperativeriskanddifficultyestimationindicesriskpredictiontoolforestimatingperiandpostoperativeoutcomesincludingsurgicaldifficultyinmajorurologicalsurgeryaprotocolforadelphistudy AT jochenwalz developmentofthecamusintraandpostoperativeriskanddifficultyestimationindicesriskpredictiontoolforestimatingperiandpostoperativeoutcomesincludingsurgicaldifficultyinmajorurologicalsurgeryaprotocolforadelphistudy AT niallmcorcoran developmentofthecamusintraandpostoperativeriskanddifficultyestimationindicesriskpredictiontoolforestimatingperiandpostoperativeoutcomesincludingsurgicaldifficultyinmajorurologicalsurgeryaprotocolforadelphistudy AT nathanlawrentschuk developmentofthecamusintraandpostoperativeriskanddifficultyestimationindicesriskpredictiontoolforestimatingperiandpostoperativeoutcomesincludingsurgicaldifficultyinmajorurologicalsurgeryaprotocolforadelphistudy AT annawalde developmentofthecamusintraandpostoperativeriskanddifficultyestimationindicesriskpredictiontoolforestimatingperiandpostoperativeoutcomesincludingsurgicaldifficultyinmajorurologicalsurgeryaprotocolforadelphistudy AT marcafurrer developmentofthecamusintraandpostoperativeriskanddifficultyestimationindicesriskpredictiontoolforestimatingperiandpostoperativeoutcomesincludingsurgicaldifficultyinmajorurologicalsurgeryaprotocolforadelphistudy |