Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.
<h4>Background</h4>Targeting interventions to areas that have recently experienced cases of disease is one strategy to contain outbreaks of infectious disease. Such case-area targeted interventions (CATI) have become an increasingly popular approach for dengue control but there is little...
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| Format: | Article |
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Public Library of Science (PLoS)
2021-08-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0009562 |
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| author | Oliver J Brady Adam J Kucharski Sebastian Funk Yalda Jafari Marnix Van Loock Guillermo Herrera-Taracena Joris Menten W John Edmunds Shuzhen Sim Lee-Ching Ng Stéphane Hué Martin L Hibberd |
| author_facet | Oliver J Brady Adam J Kucharski Sebastian Funk Yalda Jafari Marnix Van Loock Guillermo Herrera-Taracena Joris Menten W John Edmunds Shuzhen Sim Lee-Ching Ng Stéphane Hué Martin L Hibberd |
| author_sort | Oliver J Brady |
| collection | DOAJ |
| description | <h4>Background</h4>Targeting interventions to areas that have recently experienced cases of disease is one strategy to contain outbreaks of infectious disease. Such case-area targeted interventions (CATI) have become an increasingly popular approach for dengue control but there is little evidence to suggest how precisely targeted or how recent cases need to be, to mount an effective response. The growing interest in the development of prophylactic and therapeutic drugs for dengue has also given new relevance for CATI strategies to interrupt transmission or deliver early treatment.<h4>Methods/principal findings</h4>Here we develop a patch-based mathematical model of spatial dengue spread and fit it to spatiotemporal datasets from Singapore. Simulations from this model suggest CATI strategies could be effective, particularly if used in lower density areas. To maximise effectiveness, increasing the size of the radius around an index case should be prioritised even if it results in delays in the intervention being applied. This is partially because large intervention radii ensure individuals receive multiple and regular rounds of drug dosing or vector control, and thus boost overall coverage. Given equivalent efficacy, CATIs using prophylactic drugs are predicted to be more effective than adult mosquito-killing vector control methods and may even offer the possibility of interrupting individual chains of transmission if rapidly deployed. CATI strategies quickly lose their effectiveness if baseline transmission increases or case detection rates fall.<h4>Conclusions/significance</h4>These results suggest CATI strategies can play an important role in dengue control but are likely to be most relevant for low transmission areas where high coverage of other non-reactive interventions already exists. Controlled field trials are needed to assess the field efficacy and practical constraints of large operational CATI strategies. |
| format | Article |
| id | doaj-art-6a745354fac048e69f32bee0153e1f90 |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-6a745354fac048e69f32bee0153e1f902025-08-20T03:25:19ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352021-08-01158e000956210.1371/journal.pntd.0009562Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore.Oliver J BradyAdam J KucharskiSebastian FunkYalda JafariMarnix Van LoockGuillermo Herrera-TaracenaJoris MentenW John EdmundsShuzhen SimLee-Ching NgStéphane HuéMartin L Hibberd<h4>Background</h4>Targeting interventions to areas that have recently experienced cases of disease is one strategy to contain outbreaks of infectious disease. Such case-area targeted interventions (CATI) have become an increasingly popular approach for dengue control but there is little evidence to suggest how precisely targeted or how recent cases need to be, to mount an effective response. The growing interest in the development of prophylactic and therapeutic drugs for dengue has also given new relevance for CATI strategies to interrupt transmission or deliver early treatment.<h4>Methods/principal findings</h4>Here we develop a patch-based mathematical model of spatial dengue spread and fit it to spatiotemporal datasets from Singapore. Simulations from this model suggest CATI strategies could be effective, particularly if used in lower density areas. To maximise effectiveness, increasing the size of the radius around an index case should be prioritised even if it results in delays in the intervention being applied. This is partially because large intervention radii ensure individuals receive multiple and regular rounds of drug dosing or vector control, and thus boost overall coverage. Given equivalent efficacy, CATIs using prophylactic drugs are predicted to be more effective than adult mosquito-killing vector control methods and may even offer the possibility of interrupting individual chains of transmission if rapidly deployed. CATI strategies quickly lose their effectiveness if baseline transmission increases or case detection rates fall.<h4>Conclusions/significance</h4>These results suggest CATI strategies can play an important role in dengue control but are likely to be most relevant for low transmission areas where high coverage of other non-reactive interventions already exists. Controlled field trials are needed to assess the field efficacy and practical constraints of large operational CATI strategies.https://doi.org/10.1371/journal.pntd.0009562 |
| spellingShingle | Oliver J Brady Adam J Kucharski Sebastian Funk Yalda Jafari Marnix Van Loock Guillermo Herrera-Taracena Joris Menten W John Edmunds Shuzhen Sim Lee-Ching Ng Stéphane Hué Martin L Hibberd Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. PLoS Neglected Tropical Diseases |
| title | Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
| title_full | Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
| title_fullStr | Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
| title_full_unstemmed | Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
| title_short | Case-area targeted interventions (CATI) for reactive dengue control: Modelling effectiveness of vector control and prophylactic drugs in Singapore. |
| title_sort | case area targeted interventions cati for reactive dengue control modelling effectiveness of vector control and prophylactic drugs in singapore |
| url | https://doi.org/10.1371/journal.pntd.0009562 |
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