Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma

Abstract Piezo1 is identified as a novel mechanosensitive ion channel protein regulating a variety of physiological and pathological processes. However, the cellular effects of activation of Piezo1 protein on hepatocellular carcinoma (HCC) remains to be illuminated. In this study, we investigated th...

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Main Authors: Juanfen Mo, YuXuan Zhang, Chenxi Cao, WeiLi Zheng, Li Zheng, Xiaoguang Wang, Shiyue Wang, Jiayuan Wu, Yi Bao
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
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Online Access:https://doi.org/10.1186/s12964-025-02289-7
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