Seasonal influenza vaccine performance and the potential benefits of mRNA vaccines
Influenza remains a public health threat, partly due to suboptimal effectiveness of vaccines. One factor impacting vaccine effectiveness is strain mismatch, occurring when vaccines no longer match circulating strains due to antigenic drift or the incorporation of inadvertent (eg, egg-adaptive) mutat...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2336357 |
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| author | Colin A. Russell Ron A. M. Fouchier Parinaz Ghaswalla Yoonyoung Park Nevena Vicic Jintanat Ananworanich Raffael Nachbagauer Deborah Rudin |
| author_facet | Colin A. Russell Ron A. M. Fouchier Parinaz Ghaswalla Yoonyoung Park Nevena Vicic Jintanat Ananworanich Raffael Nachbagauer Deborah Rudin |
| author_sort | Colin A. Russell |
| collection | DOAJ |
| description | Influenza remains a public health threat, partly due to suboptimal effectiveness of vaccines. One factor impacting vaccine effectiveness is strain mismatch, occurring when vaccines no longer match circulating strains due to antigenic drift or the incorporation of inadvertent (eg, egg-adaptive) mutations during vaccine manufacturing. In this review, we summarize the evidence for antigenic drift of circulating viruses and/or egg-adaptive mutations occurring in vaccine strains during the 2011–2020 influenza seasons. Evidence suggests that antigenic drift led to vaccine mismatch during four seasons and that egg-adaptive mutations caused vaccine mismatch during six seasons. These findings highlight the need for alternative vaccine development platforms. Recently, vaccines based on mRNA technology have demonstrated efficacy against SARS-CoV-2 and respiratory syncytial virus and are under clinical evaluation for seasonal influenza. We discuss the potential for mRNA vaccines to address strain mismatch, as well as new multi-component strategies using the mRNA platform to improve vaccine effectiveness. |
| format | Article |
| id | doaj-art-6a73d975b6bf4fc69c8881c1d8d5e4bf |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-6a73d975b6bf4fc69c8881c1d8d5e4bf2025-08-20T03:22:20ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2336357Seasonal influenza vaccine performance and the potential benefits of mRNA vaccinesColin A. Russell0Ron A. M. Fouchier1Parinaz Ghaswalla2Yoonyoung Park3Nevena Vicic4Jintanat Ananworanich5Raffael Nachbagauer6Deborah Rudin7Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the NetherlandsDepartment of Viroscience, Erasmus Medical Center, Rotterdam, the NetherlandsModerna, Inc., Cambridge, MA, USAModerna, Inc., Cambridge, MA, USAModerna, Inc., Cambridge, MA, USAModerna, Inc., Cambridge, MA, USAModerna, Inc., Cambridge, MA, USAModerna, Inc., Cambridge, MA, USAInfluenza remains a public health threat, partly due to suboptimal effectiveness of vaccines. One factor impacting vaccine effectiveness is strain mismatch, occurring when vaccines no longer match circulating strains due to antigenic drift or the incorporation of inadvertent (eg, egg-adaptive) mutations during vaccine manufacturing. In this review, we summarize the evidence for antigenic drift of circulating viruses and/or egg-adaptive mutations occurring in vaccine strains during the 2011–2020 influenza seasons. Evidence suggests that antigenic drift led to vaccine mismatch during four seasons and that egg-adaptive mutations caused vaccine mismatch during six seasons. These findings highlight the need for alternative vaccine development platforms. Recently, vaccines based on mRNA technology have demonstrated efficacy against SARS-CoV-2 and respiratory syncytial virus and are under clinical evaluation for seasonal influenza. We discuss the potential for mRNA vaccines to address strain mismatch, as well as new multi-component strategies using the mRNA platform to improve vaccine effectiveness.https://www.tandfonline.com/doi/10.1080/21645515.2024.2336357Influenzavaccinationvaccine effectivenessvaccine manufacturingantigenic driftegg-adaptive mutations |
| spellingShingle | Colin A. Russell Ron A. M. Fouchier Parinaz Ghaswalla Yoonyoung Park Nevena Vicic Jintanat Ananworanich Raffael Nachbagauer Deborah Rudin Seasonal influenza vaccine performance and the potential benefits of mRNA vaccines Human Vaccines & Immunotherapeutics Influenza vaccination vaccine effectiveness vaccine manufacturing antigenic drift egg-adaptive mutations |
| title | Seasonal influenza vaccine performance and the potential benefits of mRNA vaccines |
| title_full | Seasonal influenza vaccine performance and the potential benefits of mRNA vaccines |
| title_fullStr | Seasonal influenza vaccine performance and the potential benefits of mRNA vaccines |
| title_full_unstemmed | Seasonal influenza vaccine performance and the potential benefits of mRNA vaccines |
| title_short | Seasonal influenza vaccine performance and the potential benefits of mRNA vaccines |
| title_sort | seasonal influenza vaccine performance and the potential benefits of mrna vaccines |
| topic | Influenza vaccination vaccine effectiveness vaccine manufacturing antigenic drift egg-adaptive mutations |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2336357 |
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