Sequencing whole genomes of the West Javanese population in Indonesia reveals novel variants and improves imputation accuracy

Sequencing whole genomes of the West Javanese population in Indonesia reveals novel variants and improves imputation accuracy

Existing genotype imputation reference panels are mainly derived from European populations, limiting their accuracy in non-European populations. To improve imputation accuracy for Indonesians, the world’s fourth most populous country, we combined Whole Genome Sequencing (WGS) data from 227 West Java...

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Bibliographic Details
Main Authors: Edwin Ardiansyah, Anca-Lelia Riza, Sofiati Dian, Ahmad Rizal Ganiem, Bachti Alisjahbana, Todia P. Setiabudiawan, Arjan van Laarhoven, Reinout van Crevel, Vinod Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Genetics
Subjects:
whole genome sequencing
imputation reference panel
Indonesian genetic architecture
GWAS
West Javanese genetics
imputation accuracy
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1492602/full
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https://www.frontiersin.org/articles/10.3389/fgene.2024.1492602/full

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