High frequency repetitive transcranial magnetic stimulation for auditory verbal hallucinations in schizophrenia-spectrum disorders: a naturalistic study
BackgroundThis study investigates the efficacy of high frequency repetitive transcranial magnetic stimulation (rTMS) for auditory verbal hallucinations in patients with schizophrenia spectrum disorders in routine clinical practice.MethodsIn this monocentric study, data were collected on patients wit...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1551901/full |
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| author | Virginie Moulier Virginie Moulier Charlotte Lemonnier Sonia Dollfus Sonia Dollfus Sonia Dollfus Sonia Dollfus Olivier Guillin Olivier Guillin Olivier Guillin Olivier Guillin Olivier Guillin Maud Rothärmel Maud Rothärmel Maud Rothärmel |
| author_facet | Virginie Moulier Virginie Moulier Charlotte Lemonnier Sonia Dollfus Sonia Dollfus Sonia Dollfus Sonia Dollfus Olivier Guillin Olivier Guillin Olivier Guillin Olivier Guillin Olivier Guillin Maud Rothärmel Maud Rothärmel Maud Rothärmel |
| author_sort | Virginie Moulier |
| collection | DOAJ |
| description | BackgroundThis study investigates the efficacy of high frequency repetitive transcranial magnetic stimulation (rTMS) for auditory verbal hallucinations in patients with schizophrenia spectrum disorders in routine clinical practice.MethodsIn this monocentric study, data were collected on patients with schizophrenia treated by rTMS for resistant auditory verbal hallucinations from May 2020 to May 2024. Treatment efficacy was regularly assessed.ResultsThe data of 65 patients were collected. There was a significant improvement in the Auditory Hallucination Rating Scale (AHRS, p<0.001), in the Brief psychiatric Rating scale (BPRS, p<0.001) and in the Clinical Global Impression-Improvement (p<0.001) scores over time (from baseline up to six months). The maximum response rate (40%) was obtained after nine weeks of rTMS (on average (SD), after 30.6 (7.8) rTMS sessions). The responders were significantly younger than non-responders (p=0.002). The good tolerance of the rTMS treatment allowed excellent compliance: only seven patients (10.8%) asked to stop rTMS or were non-compliant.ConclusionThese data show the clinical interest and the good tolerance of rTMS in daily practice in patients with schizophrenia suffering from auditory verbal hallucinations. |
| format | Article |
| id | doaj-art-6a6c343e43f74ef8bed17f81bc59c950 |
| institution | DOAJ |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-6a6c343e43f74ef8bed17f81bc59c9502025-08-20T03:07:51ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-06-011610.3389/fpsyt.2025.15519011551901High frequency repetitive transcranial magnetic stimulation for auditory verbal hallucinations in schizophrenia-spectrum disorders: a naturalistic studyVirginie Moulier0Virginie Moulier1Charlotte Lemonnier2Sonia Dollfus3Sonia Dollfus4Sonia Dollfus5Sonia Dollfus6Olivier Guillin7Olivier Guillin8Olivier Guillin9Olivier Guillin10Olivier Guillin11Maud Rothärmel12Maud Rothärmel13Maud Rothärmel14Centre Hospitalier du Rouvray, Service Hospitalo-Universitaire de Psychiatrie, Centre d’Excellence Thérapeutique, Sotteville-lès-Rouen, FranceEtablissement Public de Santé (EPS) Ville Evrard, Centre de Recherche Clinique, Neuilly-sur-Marne, FranceCentre Hospitalier du Rouvray, Service Hospitalo-Universitaire de Psychiatrie, Centre d’Excellence Thérapeutique, Sotteville-lès-Rouen, FranceInserm UMR-S 1237 PhIND, Presage team, GIP Cyceron, Caen, FranceNormandie Univ, Université de Caen Normandie (UNICAEN), UFR de Médecine, Caen, FranceCHU de Caen, Service de Psychiatrie, Caen, FranceFédération Hospitalo-Universitaire (FHU) A2M2P- CHU, Caen, FranceCentre Hospitalier du Rouvray, Service Hospitalo-Universitaire de Psychiatrie, Centre d’Excellence Thérapeutique, Sotteville-lès-Rouen, FranceFédération Hospitalo-Universitaire (FHU) A2M2P- CHU, Caen, FranceDepartment of Psychiatry, Rouen University Hospital, Rouen, FranceFaculté de Médecine, Normandie University, Rouen, FranceINSERM U 1245, University of Rouen, Rouen, FranceCentre Hospitalier du Rouvray, Service Hospitalo-Universitaire de Psychiatrie, Centre d’Excellence Thérapeutique, Sotteville-lès-Rouen, FranceFédération Hospitalo-Universitaire (FHU) A2M2P- CHU, Caen, FranceINSERM U 1245, University of Rouen, Rouen, FranceBackgroundThis study investigates the efficacy of high frequency repetitive transcranial magnetic stimulation (rTMS) for auditory verbal hallucinations in patients with schizophrenia spectrum disorders in routine clinical practice.MethodsIn this monocentric study, data were collected on patients with schizophrenia treated by rTMS for resistant auditory verbal hallucinations from May 2020 to May 2024. Treatment efficacy was regularly assessed.ResultsThe data of 65 patients were collected. There was a significant improvement in the Auditory Hallucination Rating Scale (AHRS, p<0.001), in the Brief psychiatric Rating scale (BPRS, p<0.001) and in the Clinical Global Impression-Improvement (p<0.001) scores over time (from baseline up to six months). The maximum response rate (40%) was obtained after nine weeks of rTMS (on average (SD), after 30.6 (7.8) rTMS sessions). The responders were significantly younger than non-responders (p=0.002). The good tolerance of the rTMS treatment allowed excellent compliance: only seven patients (10.8%) asked to stop rTMS or were non-compliant.ConclusionThese data show the clinical interest and the good tolerance of rTMS in daily practice in patients with schizophrenia suffering from auditory verbal hallucinations.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1551901/fullschizophreniahallucinationsrepetitive transcranial magnetic stimulation (rTMS)high frequency rTMSleft temporo-parietal junction region |
| spellingShingle | Virginie Moulier Virginie Moulier Charlotte Lemonnier Sonia Dollfus Sonia Dollfus Sonia Dollfus Sonia Dollfus Olivier Guillin Olivier Guillin Olivier Guillin Olivier Guillin Olivier Guillin Maud Rothärmel Maud Rothärmel Maud Rothärmel High frequency repetitive transcranial magnetic stimulation for auditory verbal hallucinations in schizophrenia-spectrum disorders: a naturalistic study Frontiers in Psychiatry schizophrenia hallucinations repetitive transcranial magnetic stimulation (rTMS) high frequency rTMS left temporo-parietal junction region |
| title | High frequency repetitive transcranial magnetic stimulation for auditory verbal hallucinations in schizophrenia-spectrum disorders: a naturalistic study |
| title_full | High frequency repetitive transcranial magnetic stimulation for auditory verbal hallucinations in schizophrenia-spectrum disorders: a naturalistic study |
| title_fullStr | High frequency repetitive transcranial magnetic stimulation for auditory verbal hallucinations in schizophrenia-spectrum disorders: a naturalistic study |
| title_full_unstemmed | High frequency repetitive transcranial magnetic stimulation for auditory verbal hallucinations in schizophrenia-spectrum disorders: a naturalistic study |
| title_short | High frequency repetitive transcranial magnetic stimulation for auditory verbal hallucinations in schizophrenia-spectrum disorders: a naturalistic study |
| title_sort | high frequency repetitive transcranial magnetic stimulation for auditory verbal hallucinations in schizophrenia spectrum disorders a naturalistic study |
| topic | schizophrenia hallucinations repetitive transcranial magnetic stimulation (rTMS) high frequency rTMS left temporo-parietal junction region |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1551901/full |
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