SHMT inhibitor synergizes with 5-Fu to suppress gastric cancer via cell cycle arrest and chemoresistance alleviation

SHMT inhibitor synergizes with 5-Fu to suppress gastric cancer via cell cycle arrest and chemoresistance alleviation

Abstract Advanced gastric cancer (GC) represents a malignancy tumor with poor prognosis, which requires urgent exploration into its molecular drivers and innovative therapeutic strategies. This study investigates the oncogenic role of serine hydroxymethyltransferase isoforms (SHMT1/SHMT2), key regul...

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Bibliographic Details
Main Authors: Huan Deng, Yajie Wang, Lin Xiao, Mei Feng, Weidong Dou, Yisheng Pan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00926-5
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