Clinical and pathological characteristics of 7 cases of colorectal cancer in organ transplant recipients
[Objectives] To analyze the clinical and pathological characteristics of colorectal cancer in organ transplant recipients and provide references for clinical diagnosis and treatment. [Methods] Retrospective analysis of 7 organ transplant recipients confirmed with colorectal adenocarcinoma who underw...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Colorectal & Anal Surgery
2023-04-01
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| Series: | 结直肠肛门外科 |
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| Online Access: | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=233&cateName=2023%E5%B9%B4%20%E7%AC%AC29%E5%8D%B7%20%E7%AC%AC2%E6%9C%9F |
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| author | Wang Ye Lou Zheng Meng Ronggui Ji Liqiang Li Shuyuan Zheng Kuo Jin Lu Gong Haifeng Liu Lianjie Hao Liqiang Zhang Wei |
| author_facet | Wang Ye Lou Zheng Meng Ronggui Ji Liqiang Li Shuyuan Zheng Kuo Jin Lu Gong Haifeng Liu Lianjie Hao Liqiang Zhang Wei |
| author_sort | Wang Ye |
| collection | DOAJ |
| description | [Objectives] To analyze the clinical and pathological characteristics of colorectal cancer in organ transplant recipients and provide references for clinical diagnosis and treatment. [Methods] Retrospective analysis of 7 organ transplant recipients confirmed with colorectal adenocarcinoma who underwent radical surgery at the Department of Colorectal Surgery of the First Affiliated Hospital of Naval Medical University from September 2002 to September 2021 was performed. Clinical and pathological characteristics of colorectal cancer in organ transplant recipients were summarized and analyzed. [Results] The initial symptoms were hematochezia in 3 cases, abdominal pain in 1 case, diarrhea in 1 case, abdominal distension and vomiting in 1 case, and abnormal colonoscopy in 1 case. The preoperative serum levels of CEA were 1.61 to 123.20 ng/mL, the median serum CEA level was 5.12 (1.76, 10.28) ng/mL; the preoperative serum levels of CA199 were 4.79 to 184.96 U/mL, and the median serum CA199 level was 18.59 (9.37, 135.60) U/mL. Three patients had normal preoperative serum CEA, and five had normal preoperative serum CA199. The tumor was located in the ascending colon in 1 case, descending colon in 1 case, sigmoid colon in 1 case, rectosigmoid junction in 1 case, and rectum in 3 cases. Among them, 3 cases at stage Ⅲ, 3 cases at stage Ⅱ, and 1 case at stageⅠ;3 cases were poorly differentiated, 1 case was moderately to poorly differentiated, and 3 cases were moderately differentiated; The tumor occupied less than the entire intestinal circumference in 2 cases and the entire intestinal circumference in 5 cases. [Conclusion] Colorectal cancer in organ transplant recipients tends to occur within five years, and the tumor is usually located in the rectum, with most patients diagnosed with locally advanced stage. Therefore, for individuals who have undergone organ transplantation, it is recommended to strengthen early diagnosis and treatment of colorectal cancer to improve prognosis. |
| format | Article |
| id | doaj-art-6a609d4de61b49459afa1def42e7b78f |
| institution | OA Journals |
| issn | 1674-0491 |
| language | zho |
| publishDate | 2023-04-01 |
| publisher | Editorial Office of Journal of Colorectal & Anal Surgery |
| record_format | Article |
| series | 结直肠肛门外科 |
| spelling | doaj-art-6a609d4de61b49459afa1def42e7b78f2025-08-20T02:31:44ZzhoEditorial Office of Journal of Colorectal & Anal Surgery结直肠肛门外科1674-04912023-04-0129217017310.19668/j.cnki.issn1674-0491.2023.02.013Clinical and pathological characteristics of 7 cases of colorectal cancer in organ transplant recipientsWang Ye0Lou Zheng1Meng Ronggui2Ji Liqiang3Li Shuyuan4Zheng Kuo5Jin Lu6Gong Haifeng7Liu Lianjie8Hao Liqiang9Zhang Wei10Department of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, ChinaDepartment of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, ChinaDepartment of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, ChinaDepartment of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, ChinaDepartment of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, ChinaDepartment of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, ChinaDepartment of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, ChinaDepartment of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, ChinaDepartment of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, ChinaDepartment of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, ChinaDepartment of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China[Objectives] To analyze the clinical and pathological characteristics of colorectal cancer in organ transplant recipients and provide references for clinical diagnosis and treatment. [Methods] Retrospective analysis of 7 organ transplant recipients confirmed with colorectal adenocarcinoma who underwent radical surgery at the Department of Colorectal Surgery of the First Affiliated Hospital of Naval Medical University from September 2002 to September 2021 was performed. Clinical and pathological characteristics of colorectal cancer in organ transplant recipients were summarized and analyzed. [Results] The initial symptoms were hematochezia in 3 cases, abdominal pain in 1 case, diarrhea in 1 case, abdominal distension and vomiting in 1 case, and abnormal colonoscopy in 1 case. The preoperative serum levels of CEA were 1.61 to 123.20 ng/mL, the median serum CEA level was 5.12 (1.76, 10.28) ng/mL; the preoperative serum levels of CA199 were 4.79 to 184.96 U/mL, and the median serum CA199 level was 18.59 (9.37, 135.60) U/mL. Three patients had normal preoperative serum CEA, and five had normal preoperative serum CA199. The tumor was located in the ascending colon in 1 case, descending colon in 1 case, sigmoid colon in 1 case, rectosigmoid junction in 1 case, and rectum in 3 cases. Among them, 3 cases at stage Ⅲ, 3 cases at stage Ⅱ, and 1 case at stageⅠ;3 cases were poorly differentiated, 1 case was moderately to poorly differentiated, and 3 cases were moderately differentiated; The tumor occupied less than the entire intestinal circumference in 2 cases and the entire intestinal circumference in 5 cases. [Conclusion] Colorectal cancer in organ transplant recipients tends to occur within five years, and the tumor is usually located in the rectum, with most patients diagnosed with locally advanced stage. Therefore, for individuals who have undergone organ transplantation, it is recommended to strengthen early diagnosis and treatment of colorectal cancer to improve prognosis.https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=233&cateName=2023%E5%B9%B4%20%E7%AC%AC29%E5%8D%B7%20%E7%AC%AC2%E6%9C%9Fcolorectal cancerorgan transplantclinicopathologic features |
| spellingShingle | Wang Ye Lou Zheng Meng Ronggui Ji Liqiang Li Shuyuan Zheng Kuo Jin Lu Gong Haifeng Liu Lianjie Hao Liqiang Zhang Wei Clinical and pathological characteristics of 7 cases of colorectal cancer in organ transplant recipients 结直肠肛门外科 colorectal cancer organ transplant clinicopathologic features |
| title | Clinical and pathological characteristics of 7 cases of colorectal cancer in organ transplant recipients |
| title_full | Clinical and pathological characteristics of 7 cases of colorectal cancer in organ transplant recipients |
| title_fullStr | Clinical and pathological characteristics of 7 cases of colorectal cancer in organ transplant recipients |
| title_full_unstemmed | Clinical and pathological characteristics of 7 cases of colorectal cancer in organ transplant recipients |
| title_short | Clinical and pathological characteristics of 7 cases of colorectal cancer in organ transplant recipients |
| title_sort | clinical and pathological characteristics of 7 cases of colorectal cancer in organ transplant recipients |
| topic | colorectal cancer organ transplant clinicopathologic features |
| url | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=233&cateName=2023%E5%B9%B4%20%E7%AC%AC29%E5%8D%B7%20%E7%AC%AC2%E6%9C%9F |
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