Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer
Genetic polymorphisms in DNA repair genes may induce individual variations in DNA repair capacity, which may in turn contribute to the risk of cancer developing. Homologous recombination repair (HRR) plays a critical role in maintaining chromosomal integrity and protecting against carcinogenic facto...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/828646 |
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| author | Maria Nowacka-Zawisza Ewelina Wiśnik Andrzej Wasilewski Milena Skowrońska Ewa Forma Magdalena Bryś Waldemar Różański Wanda M. Krajewska |
| author_facet | Maria Nowacka-Zawisza Ewelina Wiśnik Andrzej Wasilewski Milena Skowrońska Ewa Forma Magdalena Bryś Waldemar Różański Wanda M. Krajewska |
| author_sort | Maria Nowacka-Zawisza |
| collection | DOAJ |
| description | Genetic polymorphisms in DNA repair genes may induce individual variations in DNA repair capacity, which may in turn contribute to the risk of cancer developing. Homologous recombination repair (HRR) plays a critical role in maintaining chromosomal integrity and protecting against carcinogenic factors. The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms (SNPs) in the genes involved in HRR, that is, RAD51 (rs1801320 and rs1801321), RAD51B (rs10483813 and rs3784099), XRCC2 (rs3218536), and XRCC3 (rs861539). Polymorphisms were analyzed by PCR-RFLP and Real-Time PCR in 101 patients with prostate adenocarcinoma and 216 age- and sex-matched controls. A significant relationship was detected between the RAD51 gene rs1801320 polymorphism and increased prostate cancer risk. Our results indicate that the RAD51 gene rs1801320 polymorphism may contribute to prostate cancer susceptibility in Poland. |
| format | Article |
| id | doaj-art-6a607255e66d4fa0b916ae7124d1b1ef |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-6a607255e66d4fa0b916ae7124d1b1ef2025-02-03T00:58:54ZengWileyAnalytical Cellular Pathology2210-71772210-71852015-01-01201510.1155/2015/828646828646Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate CancerMaria Nowacka-Zawisza0Ewelina Wiśnik1Andrzej Wasilewski2Milena Skowrońska3Ewa Forma4Magdalena Bryś5Waldemar Różański6Wanda M. Krajewska7Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland2nd Department of Urology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, 93-513 Lodz, PolandDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, PolandGenetic polymorphisms in DNA repair genes may induce individual variations in DNA repair capacity, which may in turn contribute to the risk of cancer developing. Homologous recombination repair (HRR) plays a critical role in maintaining chromosomal integrity and protecting against carcinogenic factors. The aim of the present study was to evaluate the relationship between prostate cancer risk and the presence of single nucleotide polymorphisms (SNPs) in the genes involved in HRR, that is, RAD51 (rs1801320 and rs1801321), RAD51B (rs10483813 and rs3784099), XRCC2 (rs3218536), and XRCC3 (rs861539). Polymorphisms were analyzed by PCR-RFLP and Real-Time PCR in 101 patients with prostate adenocarcinoma and 216 age- and sex-matched controls. A significant relationship was detected between the RAD51 gene rs1801320 polymorphism and increased prostate cancer risk. Our results indicate that the RAD51 gene rs1801320 polymorphism may contribute to prostate cancer susceptibility in Poland.http://dx.doi.org/10.1155/2015/828646 |
| spellingShingle | Maria Nowacka-Zawisza Ewelina Wiśnik Andrzej Wasilewski Milena Skowrońska Ewa Forma Magdalena Bryś Waldemar Różański Wanda M. Krajewska Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer Analytical Cellular Pathology |
| title | Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer |
| title_full | Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer |
| title_fullStr | Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer |
| title_full_unstemmed | Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer |
| title_short | Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer |
| title_sort | polymorphisms of homologous recombination rad51 rad51b xrcc2 and xrcc3 genes and the risk of prostate cancer |
| url | http://dx.doi.org/10.1155/2015/828646 |
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