Development of a multiplex loop-mediated isothermal amplification (LAMP) method for differential detection of Mycobacterium bovis and Mycobacterium tuberculosis by dipstick DNA chromatography

Development of a multiplex loop-mediated isothermal amplification (LAMP) method for differential detection of Mycobacterium bovis and Mycobacterium tuberculosis by dipstick DNA chromatography

ABSTRACT Although human tuberculosis (TB) caused by Mycobacterium bovis is clinically, pathologically, and radiologically indistinguishable from Mycobacterium tuberculosis-caused TB, M. bovis is innately resistant to pyrazinamide, a key first-line drug effective against M. tuberculosis. The rapid di...

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Main Authors: Mwangala L. Akapelwa, Thoko F. Kapalamula, Lavel C. Moonga, Precious Bwalya, Eddie S. Solo, Joseph Y. Chizimu, Jeewan Thapa, Kyoko Hayashida, Bernard M. Hang'ombe, Musso Munyeme, Aki Tamaru, Takayuki Wada, Shiomi Yoshida, Takuya Kodera, Mistuo Kawase, Stephen V. Gordon, Keiko Yamada, Chie Nakajima, Yasuhiko Suzuki
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:Microbiology Spectrum
Subjects:
M. bovis
M. tuberculosis
simultaneous detection
multiplex LAMP
dipstick chromatography
biovar differentiation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02421-24
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