Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery
Lymphangiogenesis, the formation of new lymphatic vessels, is essential for embryonic development and the maintenance of tissue fluid balance, as well as for responding to physiological challenges such as injury, inflammation, and oedema. This process is also aberrantly activated in pathological con...
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MDPI AG
2025-07-01
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| author | Srdjan Boskovic Kazuhide Shaun Okuda |
| author_facet | Srdjan Boskovic Kazuhide Shaun Okuda |
| author_sort | Srdjan Boskovic |
| collection | DOAJ |
| description | Lymphangiogenesis, the formation of new lymphatic vessels, is essential for embryonic development and the maintenance of tissue fluid balance, as well as for responding to physiological challenges such as injury, inflammation, and oedema. This process is also aberrantly activated in pathological conditions including lymphatic anomalies and cancer. Understanding the molecular and cellular mechanisms regulating induced lymphangiogenesis in various conditions is critical for the development of novel anti- or pro-lymphangiogenic therapeutic strategies. In recent years, the zebrafish has emerged as an important model organism for studying both physiological and pathological lymphangiogenesis. Its optical transparency, conserved lymphatic architecture and signalling pathways, and amenability to genetic manipulation and drug screening make it an especially well-suited model. In this review, we highlight zebrafish models used to investigate induced lymphangiogenesis in the context of regeneration, inflammation, fluid imbalance, and congenital lymphatic anomalies. We will also demonstrate how zebrafish are used to discover new drugs targeting lymphatic vessels under various conditions. Finally, we will discuss the current limitations of using zebrafish to model induced lymphangiogenesis and highlight potential future directions. The findings presented in this review underscore the undeniable value the zebrafish model brings to lymphatic research and therapeutic discovery. |
| format | Article |
| id | doaj-art-6a4fe674fefc4d129eeb8c68cc834915 |
| institution | DOAJ |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
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| series | Pharmaceuticals |
| spelling | doaj-art-6a4fe674fefc4d129eeb8c68cc8349152025-08-20T03:07:55ZengMDPI AGPharmaceuticals1424-82472025-07-01187107610.3390/ph18071076Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic DiscoverySrdjan Boskovic0Kazuhide Shaun Okuda1Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC 3086, AustraliaDepartment of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC 3086, AustraliaLymphangiogenesis, the formation of new lymphatic vessels, is essential for embryonic development and the maintenance of tissue fluid balance, as well as for responding to physiological challenges such as injury, inflammation, and oedema. This process is also aberrantly activated in pathological conditions including lymphatic anomalies and cancer. Understanding the molecular and cellular mechanisms regulating induced lymphangiogenesis in various conditions is critical for the development of novel anti- or pro-lymphangiogenic therapeutic strategies. In recent years, the zebrafish has emerged as an important model organism for studying both physiological and pathological lymphangiogenesis. Its optical transparency, conserved lymphatic architecture and signalling pathways, and amenability to genetic manipulation and drug screening make it an especially well-suited model. In this review, we highlight zebrafish models used to investigate induced lymphangiogenesis in the context of regeneration, inflammation, fluid imbalance, and congenital lymphatic anomalies. We will also demonstrate how zebrafish are used to discover new drugs targeting lymphatic vessels under various conditions. Finally, we will discuss the current limitations of using zebrafish to model induced lymphangiogenesis and highlight potential future directions. The findings presented in this review underscore the undeniable value the zebrafish model brings to lymphatic research and therapeutic discovery.https://www.mdpi.com/1424-8247/18/7/1076zebrafishlymphaticlymphatic diseaseregenerationdrug discovery |
| spellingShingle | Srdjan Boskovic Kazuhide Shaun Okuda Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery Pharmaceuticals zebrafish lymphatic lymphatic disease regeneration drug discovery |
| title | Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery |
| title_full | Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery |
| title_fullStr | Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery |
| title_full_unstemmed | Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery |
| title_short | Zebrafish Models of Induced Lymphangiogenesis: Current Advancements and Therapeutic Discovery |
| title_sort | zebrafish models of induced lymphangiogenesis current advancements and therapeutic discovery |
| topic | zebrafish lymphatic lymphatic disease regeneration drug discovery |
| url | https://www.mdpi.com/1424-8247/18/7/1076 |
| work_keys_str_mv | AT srdjanboskovic zebrafishmodelsofinducedlymphangiogenesiscurrentadvancementsandtherapeuticdiscovery AT kazuhideshaunokuda zebrafishmodelsofinducedlymphangiogenesiscurrentadvancementsandtherapeuticdiscovery |