Effectiveness and equity of vaccination strategies against Rift Valley fever in a heterogeneous landscape.
Spatio-temporal variations in environmental and socio-agricultural factors create heterogeneity in livestock disease transmission risk, raising challenges in identifying populations most at risk and how this risk changes over time. Consequently, effective vaccination strategies require careful plann...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-07-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0013346 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850039139543547904 |
|---|---|
| author | Warren S D Tennant Eric Cardinale Youssouf Moutroifi Simon E F Spencer Onzade Charafouddine Michael J Tildesley Raphaëlle Métras |
| author_facet | Warren S D Tennant Eric Cardinale Youssouf Moutroifi Simon E F Spencer Onzade Charafouddine Michael J Tildesley Raphaëlle Métras |
| author_sort | Warren S D Tennant |
| collection | DOAJ |
| description | Spatio-temporal variations in environmental and socio-agricultural factors create heterogeneity in livestock disease transmission risk, raising challenges in identifying populations most at risk and how this risk changes over time. Consequently, effective vaccination strategies require careful planning to achieve optimal or equitable outcomes across regions. We developed a metapopulation model for Rift Valley fever transmission in livestock across the Comoros archipelago which incorporates livestock vaccination in addition to heterogeneity in viral transmission rates and animal movements. We used the model to evaluate three vaccine allocation strategies-proportional allocation, optimal allocation for maximising total infections averted across the archipelago, and optimal allocation for more equitable outcomes across islands-under different vaccination coverage levels and animal identification scenarios. We report that (i) both archipelago-wide and island-specific strategy effectiveness were impacted by vaccination rate, allocation strategy, and animal identification approach, (ii) optimally allocating vaccines improved strategy effectiveness compared with proportional allocation but resulted in inequitable outcomes between islands, and (iii) tagging animals post-vaccination boosted overall strategy effectiveness for all vaccination rates. |
| format | Article |
| id | doaj-art-6a4f6950a3df49999eb3bc3d19416ec0 |
| institution | DOAJ |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-6a4f6950a3df49999eb3bc3d19416ec02025-08-20T02:56:25ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352025-07-01197e001334610.1371/journal.pntd.0013346Effectiveness and equity of vaccination strategies against Rift Valley fever in a heterogeneous landscape.Warren S D TennantEric CardinaleYoussouf MoutroifiSimon E F SpencerOnzade CharafouddineMichael J TildesleyRaphaëlle MétrasSpatio-temporal variations in environmental and socio-agricultural factors create heterogeneity in livestock disease transmission risk, raising challenges in identifying populations most at risk and how this risk changes over time. Consequently, effective vaccination strategies require careful planning to achieve optimal or equitable outcomes across regions. We developed a metapopulation model for Rift Valley fever transmission in livestock across the Comoros archipelago which incorporates livestock vaccination in addition to heterogeneity in viral transmission rates and animal movements. We used the model to evaluate three vaccine allocation strategies-proportional allocation, optimal allocation for maximising total infections averted across the archipelago, and optimal allocation for more equitable outcomes across islands-under different vaccination coverage levels and animal identification scenarios. We report that (i) both archipelago-wide and island-specific strategy effectiveness were impacted by vaccination rate, allocation strategy, and animal identification approach, (ii) optimally allocating vaccines improved strategy effectiveness compared with proportional allocation but resulted in inequitable outcomes between islands, and (iii) tagging animals post-vaccination boosted overall strategy effectiveness for all vaccination rates.https://doi.org/10.1371/journal.pntd.0013346 |
| spellingShingle | Warren S D Tennant Eric Cardinale Youssouf Moutroifi Simon E F Spencer Onzade Charafouddine Michael J Tildesley Raphaëlle Métras Effectiveness and equity of vaccination strategies against Rift Valley fever in a heterogeneous landscape. PLoS Neglected Tropical Diseases |
| title | Effectiveness and equity of vaccination strategies against Rift Valley fever in a heterogeneous landscape. |
| title_full | Effectiveness and equity of vaccination strategies against Rift Valley fever in a heterogeneous landscape. |
| title_fullStr | Effectiveness and equity of vaccination strategies against Rift Valley fever in a heterogeneous landscape. |
| title_full_unstemmed | Effectiveness and equity of vaccination strategies against Rift Valley fever in a heterogeneous landscape. |
| title_short | Effectiveness and equity of vaccination strategies against Rift Valley fever in a heterogeneous landscape. |
| title_sort | effectiveness and equity of vaccination strategies against rift valley fever in a heterogeneous landscape |
| url | https://doi.org/10.1371/journal.pntd.0013346 |
| work_keys_str_mv | AT warrensdtennant effectivenessandequityofvaccinationstrategiesagainstriftvalleyfeverinaheterogeneouslandscape AT ericcardinale effectivenessandequityofvaccinationstrategiesagainstriftvalleyfeverinaheterogeneouslandscape AT youssoufmoutroifi effectivenessandequityofvaccinationstrategiesagainstriftvalleyfeverinaheterogeneouslandscape AT simonefspencer effectivenessandequityofvaccinationstrategiesagainstriftvalleyfeverinaheterogeneouslandscape AT onzadecharafouddine effectivenessandequityofvaccinationstrategiesagainstriftvalleyfeverinaheterogeneouslandscape AT michaeljtildesley effectivenessandequityofvaccinationstrategiesagainstriftvalleyfeverinaheterogeneouslandscape AT raphaellemetras effectivenessandequityofvaccinationstrategiesagainstriftvalleyfeverinaheterogeneouslandscape |