Combination of dapagliflozin and pioglitazone lacks superiority against monotherapy in streptozotocin-induced nephropathy

Combination of dapagliflozin and pioglitazone lacks superiority against monotherapy in streptozotocin-induced nephropathy

Abstract Oxidative stress and apoptosis are highly engaged in development of diabetic nephropathy (DN). In monotherapy, dapagliflozin and pioglitazone positively modulate target organ damage even independently of their hypoglycaemic effect. This study evaluated whether a simultaneous PPARγ activatio...

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Bibliographic Details
Main Authors: Aneta Cinakova, Diana Vavrincova-Yaghi, Peter Krenek, Jan Klimas, Eva Kralova
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Diabetic nephropathy
Rat
Dapagliflozin
Pioglitazone
Diabetes mellitus
Online Access:https://doi.org/10.1038/s41598-024-84487-w
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