SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes.
<h4>Objective</h4>To examine the impact of SARS-CoV-2 on long-term glycemia.<h4>Research design and methods</h4>We conducted a retrospective inception cohort study using Veterans Health Administration data (March 1, 2020-May 31, 2022) among individuals with ≥ 1 positive nasal...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0317348 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850143391048794112 |
|---|---|
| author | Pandora L Wander Elliott Lowy Anna Korpak Lauren A Beste Steven E Kahn Edward J Boyko |
| author_facet | Pandora L Wander Elliott Lowy Anna Korpak Lauren A Beste Steven E Kahn Edward J Boyko |
| author_sort | Pandora L Wander |
| collection | DOAJ |
| description | <h4>Objective</h4>To examine the impact of SARS-CoV-2 on long-term glycemia.<h4>Research design and methods</h4>We conducted a retrospective inception cohort study using Veterans Health Administration data (March 1, 2020-May 31, 2022) among individuals with ≥ 1 positive nasal swab for SARS-CoV-2 and individuals with ≥ 1 laboratory test of any type but no positive swab. Two incident diabetes cohorts were defined based on: 1) a computable phenotype using a combination of diagnosis codes, laboratory tests, and receipt of glucose-lowering medications (n = 17,754); and 2) the presence of ≥ 2 HbA1c results ≥ 6.5% (n = 4,768). We fit log-binomial models examining associations of SARS-CoV-2 with diabetes remission, defined as ≥ 2 HbA1c measurements < 6.5% ≥ 90 days apart after cessation of any glucose-lowering medications. To help equalize laboratory surveillance of glycemia, we conducted a subgroup analysis among non-hospitalized participants.<h4>Results</h4>In cohorts 1 and 2 respectively, 25% and 29% had ≥ 1 positive test for SARS-CoV-2 prior to enrollment, and 21% and 11% had remission. SARS-CoV-2 was associated with a higher chance of remission by both definitions (1: RR 1.22 [95%CI 1.14-1.29]; 2: RR 1.27 [95%CI 1.07-1.50]) over an average 503 (±202) and 494 (±184) days. The association was attenuated among non-hospitalized participants (1: RR 1.11 [1.04-1.20]; 2: R: 1.17 [95%CI 0.97-1.42]).<h4>Conclusions</h4>Diabetes remission was more common in Veterans with new-onset diabetes after SARS-CoV-2. In non-hospitalized participants, who were likely to have more similar laboratory surveillance, the association was diminished. Differences in surveillance or transient hyperglycemia may explain the observed association. |
| format | Article |
| id | doaj-art-6a4a2d0d8a5540c4867686caf7f006ec |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-6a4a2d0d8a5540c4867686caf7f006ec2025-08-20T02:28:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031734810.1371/journal.pone.0317348SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes.Pandora L WanderElliott LowyAnna KorpakLauren A BesteSteven E KahnEdward J Boyko<h4>Objective</h4>To examine the impact of SARS-CoV-2 on long-term glycemia.<h4>Research design and methods</h4>We conducted a retrospective inception cohort study using Veterans Health Administration data (March 1, 2020-May 31, 2022) among individuals with ≥ 1 positive nasal swab for SARS-CoV-2 and individuals with ≥ 1 laboratory test of any type but no positive swab. Two incident diabetes cohorts were defined based on: 1) a computable phenotype using a combination of diagnosis codes, laboratory tests, and receipt of glucose-lowering medications (n = 17,754); and 2) the presence of ≥ 2 HbA1c results ≥ 6.5% (n = 4,768). We fit log-binomial models examining associations of SARS-CoV-2 with diabetes remission, defined as ≥ 2 HbA1c measurements < 6.5% ≥ 90 days apart after cessation of any glucose-lowering medications. To help equalize laboratory surveillance of glycemia, we conducted a subgroup analysis among non-hospitalized participants.<h4>Results</h4>In cohorts 1 and 2 respectively, 25% and 29% had ≥ 1 positive test for SARS-CoV-2 prior to enrollment, and 21% and 11% had remission. SARS-CoV-2 was associated with a higher chance of remission by both definitions (1: RR 1.22 [95%CI 1.14-1.29]; 2: RR 1.27 [95%CI 1.07-1.50]) over an average 503 (±202) and 494 (±184) days. The association was attenuated among non-hospitalized participants (1: RR 1.11 [1.04-1.20]; 2: R: 1.17 [95%CI 0.97-1.42]).<h4>Conclusions</h4>Diabetes remission was more common in Veterans with new-onset diabetes after SARS-CoV-2. In non-hospitalized participants, who were likely to have more similar laboratory surveillance, the association was diminished. Differences in surveillance or transient hyperglycemia may explain the observed association.https://doi.org/10.1371/journal.pone.0317348 |
| spellingShingle | Pandora L Wander Elliott Lowy Anna Korpak Lauren A Beste Steven E Kahn Edward J Boyko SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes. PLoS ONE |
| title | SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes. |
| title_full | SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes. |
| title_fullStr | SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes. |
| title_full_unstemmed | SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes. |
| title_short | SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes. |
| title_sort | sars cov 2 infection is associated with higher chance of diabetes remission among veterans with incident diabetes |
| url | https://doi.org/10.1371/journal.pone.0317348 |
| work_keys_str_mv | AT pandoralwander sarscov2infectionisassociatedwithhigherchanceofdiabetesremissionamongveteranswithincidentdiabetes AT elliottlowy sarscov2infectionisassociatedwithhigherchanceofdiabetesremissionamongveteranswithincidentdiabetes AT annakorpak sarscov2infectionisassociatedwithhigherchanceofdiabetesremissionamongveteranswithincidentdiabetes AT laurenabeste sarscov2infectionisassociatedwithhigherchanceofdiabetesremissionamongveteranswithincidentdiabetes AT stevenekahn sarscov2infectionisassociatedwithhigherchanceofdiabetesremissionamongveteranswithincidentdiabetes AT edwardjboyko sarscov2infectionisassociatedwithhigherchanceofdiabetesremissionamongveteranswithincidentdiabetes |