Epidemiological characteristics and prognostic risk factors of pulmonary blastoma based on the 2021 WHO classification
Abstract Pulmonary blastoma (PB) is a rare and aggressive lung malignancy. Prior studies were confounded by inconsistent histological classifications, particularly before the 2021 World Health Organization (WHO) reclassification. This study aimed to characterize PB’s epidemiological features and pro...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-08571-5 |
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| author | Lu Yang Lei Yu Shimin Tang Ji Ma Qiang Zhou Li Liu Yong Li Na Li |
| author_facet | Lu Yang Lei Yu Shimin Tang Ji Ma Qiang Zhou Li Liu Yong Li Na Li |
| author_sort | Lu Yang |
| collection | DOAJ |
| description | Abstract Pulmonary blastoma (PB) is a rare and aggressive lung malignancy. Prior studies were confounded by inconsistent histological classifications, particularly before the 2021 World Health Organization (WHO) reclassification. This study aimed to characterize PB’s epidemiological features and prognostic factors under the updated 2021 WHO criteria. Data on patients diagnosed with PB from the The Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2020 were collected. Kaplan-Meier curves were used to evaluate overall survival (OS), and univariate/multivariate Cox regression analysis was employed to identify independent factors affecting prognosis. PB affected females more frequently (61.5%) and occurred across all ages without a clear peak. The median tumor size was 77.83 mm, with upper/lower lung lobes being common sites. Surgical resection was performed in 73.8% of patients. The 1-, 3-, and 5-year OS rates were 70.3%, 57.2%, and 51.9%, respectively. Multivariate analysis revealed age, histological grade, and surgical status as independent prognostic factors. This study provides the first comprehensive analysis of PB under the 2021 WHO classification, demonstrating improved survival outcomes compared to historical reports. Age, histological grade, and surgical intervention are critical prognostic determinants. These findings underscore the importance of accurate histological classification and surgical resection in optimizing PB management. |
| format | Article |
| id | doaj-art-6a4452ea68754d36a3e2c40a0aaff70c |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-6a4452ea68754d36a3e2c40a0aaff70c2025-08-20T03:03:25ZengNature PortfolioScientific Reports2045-23222025-07-011511710.1038/s41598-025-08571-5Epidemiological characteristics and prognostic risk factors of pulmonary blastoma based on the 2021 WHO classificationLu Yang0Lei Yu1Shimin Tang2Ji Ma3Qiang Zhou4Li Liu5Yong Li6Na Li7Suining Central HospitalSuining Central HospitalSuining Central HospitalSuining Central HospitalSuining Central HospitalSuining Central HospitalSuining Central HospitalSuining Central HospitalAbstract Pulmonary blastoma (PB) is a rare and aggressive lung malignancy. Prior studies were confounded by inconsistent histological classifications, particularly before the 2021 World Health Organization (WHO) reclassification. This study aimed to characterize PB’s epidemiological features and prognostic factors under the updated 2021 WHO criteria. Data on patients diagnosed with PB from the The Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2020 were collected. Kaplan-Meier curves were used to evaluate overall survival (OS), and univariate/multivariate Cox regression analysis was employed to identify independent factors affecting prognosis. PB affected females more frequently (61.5%) and occurred across all ages without a clear peak. The median tumor size was 77.83 mm, with upper/lower lung lobes being common sites. Surgical resection was performed in 73.8% of patients. The 1-, 3-, and 5-year OS rates were 70.3%, 57.2%, and 51.9%, respectively. Multivariate analysis revealed age, histological grade, and surgical status as independent prognostic factors. This study provides the first comprehensive analysis of PB under the 2021 WHO classification, demonstrating improved survival outcomes compared to historical reports. Age, histological grade, and surgical intervention are critical prognostic determinants. These findings underscore the importance of accurate histological classification and surgical resection in optimizing PB management.https://doi.org/10.1038/s41598-025-08571-5Pulmonary BlastomaEpidemiological characteristicsRisk factorsRare lung malignancy |
| spellingShingle | Lu Yang Lei Yu Shimin Tang Ji Ma Qiang Zhou Li Liu Yong Li Na Li Epidemiological characteristics and prognostic risk factors of pulmonary blastoma based on the 2021 WHO classification Scientific Reports Pulmonary Blastoma Epidemiological characteristics Risk factors Rare lung malignancy |
| title | Epidemiological characteristics and prognostic risk factors of pulmonary blastoma based on the 2021 WHO classification |
| title_full | Epidemiological characteristics and prognostic risk factors of pulmonary blastoma based on the 2021 WHO classification |
| title_fullStr | Epidemiological characteristics and prognostic risk factors of pulmonary blastoma based on the 2021 WHO classification |
| title_full_unstemmed | Epidemiological characteristics and prognostic risk factors of pulmonary blastoma based on the 2021 WHO classification |
| title_short | Epidemiological characteristics and prognostic risk factors of pulmonary blastoma based on the 2021 WHO classification |
| title_sort | epidemiological characteristics and prognostic risk factors of pulmonary blastoma based on the 2021 who classification |
| topic | Pulmonary Blastoma Epidemiological characteristics Risk factors Rare lung malignancy |
| url | https://doi.org/10.1038/s41598-025-08571-5 |
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