Decoding the enigmatic role of T-cadherin in tumor angiogenesis
The cadherin family, which includes T-cadherin, plays a significant role in angiogenesis, a critical process involved in tumor growth, metastasis, and recurrence. T-cadherin is extensively expressed in both normal and tumor vascular tissues and has been shown to facilitate the proliferation and migr...
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| Format: | Article |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564130/full |
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| author | Yiyang Wen Yiyang Wen Li Ma Yuanyuan Liu Huabao Xiong Dongmei Shi Dongmei Shi |
| author_facet | Yiyang Wen Yiyang Wen Li Ma Yuanyuan Liu Huabao Xiong Dongmei Shi Dongmei Shi |
| author_sort | Yiyang Wen |
| collection | DOAJ |
| description | The cadherin family, which includes T-cadherin, plays a significant role in angiogenesis, a critical process involved in tumor growth, metastasis, and recurrence. T-cadherin is extensively expressed in both normal and tumor vascular tissues and has been shown to facilitate the proliferation and migration of vascular cells in some studies. However, T-cadherin also exerts inhibitory effects on angiogenesis in various tumor tissues. The functional role of T-cadherin may vary depending on the tumor type and the interaction between tumor cells and vascular cells, suggesting that it acts as a modulator rather than a primary driver of angiogenesis. Additionally, T-cadherin exhibits distinct characteristics depending on the tumor microenvironment. This review provides an overview of recent research on the role of T-cadherin in tumor angiogenesis and discusses its potential as a diagnostic or therapeutic marker in the field of tumor biology. |
| format | Article |
| id | doaj-art-6a4263ccaf62473793d01a00542bafdb |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-6a4263ccaf62473793d01a00542bafdb2025-08-20T02:10:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15641301564130Decoding the enigmatic role of T-cadherin in tumor angiogenesisYiyang Wen0Yiyang Wen1Li Ma2Yuanyuan Liu3Huabao Xiong4Dongmei Shi5Dongmei Shi6The Laboratory of Medical Mycology, Jining No.1 People’s Hospital, Jining, Shandong, ChinaDepartment of Pathology, Jining No.1 People’s Hospital, Jining, Shandong, ChinaThe Laboratory of Medical Mycology, Jining No.1 People’s Hospital, Jining, Shandong, ChinaThe Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong, ChinaDepartment of Pathology, Jining No.1 People’s Hospital, Jining, Shandong, ChinaDepartment of Dermatology, Jining No.1 People’s Hospital, Jining, Shandong, ChinaThe cadherin family, which includes T-cadherin, plays a significant role in angiogenesis, a critical process involved in tumor growth, metastasis, and recurrence. T-cadherin is extensively expressed in both normal and tumor vascular tissues and has been shown to facilitate the proliferation and migration of vascular cells in some studies. However, T-cadherin also exerts inhibitory effects on angiogenesis in various tumor tissues. The functional role of T-cadherin may vary depending on the tumor type and the interaction between tumor cells and vascular cells, suggesting that it acts as a modulator rather than a primary driver of angiogenesis. Additionally, T-cadherin exhibits distinct characteristics depending on the tumor microenvironment. This review provides an overview of recent research on the role of T-cadherin in tumor angiogenesis and discusses its potential as a diagnostic or therapeutic marker in the field of tumor biology.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564130/fullT-cadherinendothelial cellstumor angiogenesistumorVEGF |
| spellingShingle | Yiyang Wen Yiyang Wen Li Ma Yuanyuan Liu Huabao Xiong Dongmei Shi Dongmei Shi Decoding the enigmatic role of T-cadherin in tumor angiogenesis Frontiers in Immunology T-cadherin endothelial cells tumor angiogenesis tumor VEGF |
| title | Decoding the enigmatic role of T-cadherin in tumor angiogenesis |
| title_full | Decoding the enigmatic role of T-cadherin in tumor angiogenesis |
| title_fullStr | Decoding the enigmatic role of T-cadherin in tumor angiogenesis |
| title_full_unstemmed | Decoding the enigmatic role of T-cadherin in tumor angiogenesis |
| title_short | Decoding the enigmatic role of T-cadherin in tumor angiogenesis |
| title_sort | decoding the enigmatic role of t cadherin in tumor angiogenesis |
| topic | T-cadherin endothelial cells tumor angiogenesis tumor VEGF |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564130/full |
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