Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy

Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy

Abstract Diabetic retinopathy (DR) is a leading cause of irreversible vision loss in working-age populations. Fat mass and obesity-associated protein (FTO) is an N6-methyladenosine (m6A) demethylase that demethylates RNAs involved in energy homeostasis, though its influence on DR is not well studied...

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Bibliographic Details
Main Authors: Xue Chen, Ying Wang, Jia-Nan Wang, Yi-Chen Zhang, Ye-Ran Zhang, Ru-Xu Sun, Bing Qin, Yuan-Xin Dai, Hong-Jing Zhu, Jin-Xiang Zhao, Wei-Wei Zhang, Jiang-Dong Ji, Song-Tao Yuan, Qun-Dong Shen, Qing-Huai Liu
Format: Article
Language:English
Published: Springer Nature 2024-01-01
Series:EMBO Molecular Medicine
Subjects:
Diabetic Retinopathy (DR)
FTO
N6-Methyladenosine (m6A)
Vascular Endothelial Cells
Pericyte
Online Access:https://doi.org/10.1038/s44321-024-00025-1
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