Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS)
Objective: To provide an applied framework for assessing the genetic contribution to assortative mating (AM) using height as a model trait and disclose the trace of certain pieces of evidence of AM in the form of the shared environmental effects from long-term cohabitation on spouses’ anthropometric...
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Elsevier
2025-02-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025007819 |
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| author | Parisa Riahi Amir Hossein Saeidian Albert Tenesa Carolyn T. Hogan Michael March Kamran Guity Mahmoud Amiri Roudbar Asieh Zahedi Maryam Zarkesh Farideh Neshati Mehdi Hedayati Fereidoun Azizi Hakon Hakonarson Maryam S. Daneshpour Mahdi Akbarzadeh |
| author_facet | Parisa Riahi Amir Hossein Saeidian Albert Tenesa Carolyn T. Hogan Michael March Kamran Guity Mahmoud Amiri Roudbar Asieh Zahedi Maryam Zarkesh Farideh Neshati Mehdi Hedayati Fereidoun Azizi Hakon Hakonarson Maryam S. Daneshpour Mahdi Akbarzadeh |
| author_sort | Parisa Riahi |
| collection | DOAJ |
| description | Objective: To provide an applied framework for assessing the genetic contribution to assortative mating (AM) using height as a model trait and disclose the trace of certain pieces of evidence of AM in the form of the shared environmental effects from long-term cohabitation on spouses’ anthropometric traits and lipid serum levels. Methods: 2315 genotyped couples were extracted from the Tehran Cardiometabolic Genetic Study (TCGS). Pearson correlation analysis was used to assess the relationship between spouses' height. The GCTA-GREML was used to assess the SNP-based heritability of individual and spousal heights with AM adjustments. We used a recent GWAS meta-analysis of ∼5.4M individuals of height to calculate polygenic risk scores (PRS) for spouses’ height. A subset of 1038 spouses out of 2315 couples were subsequently selected to enter the longitudinal resemblance, to be assessed in terms of their anthropometric traits and lipid serum levels in a 15-year follow-up. We conducted a Bayesian hierarchical meta-analysis for each time point to assess the validity of the increasing trend of the longitudinal association. Results: The correlation coefficient of height between spouses was estimated as r = 0.248. We found that a person's genotype determines 6.15 % of the variation in the spouse's height. Furthermore, correlation between PRS of individuals showed a statistical association between an individual’s genotype and their spouse’s genotype (R2 = 4 %) across 1,982 couples with only one genotyped spouse, achieving approximately half of the theoretical maximum accuracy. Long-term spousal resemblance revealed an increasing trend for correlation between husbands and wives in terms of their lipid serum level and obesity-related traits. Conclusion: Our findings support the AM hypothesis for height with a significant spousal correlation and show that selecting the spouse's height is genetically determined. Besides, we provide data showing that AM is predicted to result in a10 % increase in the heritability of height, which is related to the assortative nature of alleles in the population and not to the segregation of genetic variations. Finally, as one of the evolutionary consequences of AM, long-term spousal resemblance provided an increasing trend for correlation between spouses in terms of their lipid serum level and obesity-related traits. |
| format | Article |
| id | doaj-art-6a4074db3d5a4d10baf77ccfc2d0adec |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
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| series | Heliyon |
| spelling | doaj-art-6a4074db3d5a4d10baf77ccfc2d0adec2025-02-08T05:00:43ZengElsevierHeliyon2405-84402025-02-01113e42401Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS)Parisa Riahi0Amir Hossein Saeidian1Albert Tenesa2Carolyn T. Hogan3Michael March4Kamran Guity5Mahmoud Amiri Roudbar6Asieh Zahedi7Maryam Zarkesh8Farideh Neshati9Mehdi Hedayati10Fereidoun Azizi11Hakon Hakonarson12Maryam S. Daneshpour13Mahdi Akbarzadeh14Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranCenter for Applied Genomics (CAG), The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Molecular and Human Genetics, Baylor College of Medicine., Houston, TX, USAThe Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Midlothian, Edinburgh, EH25 9RG, UK, Scotland, UK; MRC HGU at the MRC IGMM, Western General Hospital, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XU, UKDivision of Hepatology, Temple University Hospital, Philadelphia, PA, USACenter for Applied Genomics, The Children's Hospital of Philadelphia, Abramson Research Building, Suite 1016I, 3615 Civic Center Boulevard, Philadelphia, PA, 19104-4318, USACellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Animal Science, Safiabad-Dezful Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education & Extension Organization (AREEO), Dezful, IranCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEndocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranCenter for Applied Genomics (CAG), Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA, 19104, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Faculty of Medicine, University of Iceland, Reykjavik, IcelandCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, Tehran, Iran.Objective: To provide an applied framework for assessing the genetic contribution to assortative mating (AM) using height as a model trait and disclose the trace of certain pieces of evidence of AM in the form of the shared environmental effects from long-term cohabitation on spouses’ anthropometric traits and lipid serum levels. Methods: 2315 genotyped couples were extracted from the Tehran Cardiometabolic Genetic Study (TCGS). Pearson correlation analysis was used to assess the relationship between spouses' height. The GCTA-GREML was used to assess the SNP-based heritability of individual and spousal heights with AM adjustments. We used a recent GWAS meta-analysis of ∼5.4M individuals of height to calculate polygenic risk scores (PRS) for spouses’ height. A subset of 1038 spouses out of 2315 couples were subsequently selected to enter the longitudinal resemblance, to be assessed in terms of their anthropometric traits and lipid serum levels in a 15-year follow-up. We conducted a Bayesian hierarchical meta-analysis for each time point to assess the validity of the increasing trend of the longitudinal association. Results: The correlation coefficient of height between spouses was estimated as r = 0.248. We found that a person's genotype determines 6.15 % of the variation in the spouse's height. Furthermore, correlation between PRS of individuals showed a statistical association between an individual’s genotype and their spouse’s genotype (R2 = 4 %) across 1,982 couples with only one genotyped spouse, achieving approximately half of the theoretical maximum accuracy. Long-term spousal resemblance revealed an increasing trend for correlation between husbands and wives in terms of their lipid serum level and obesity-related traits. Conclusion: Our findings support the AM hypothesis for height with a significant spousal correlation and show that selecting the spouse's height is genetically determined. Besides, we provide data showing that AM is predicted to result in a10 % increase in the heritability of height, which is related to the assortative nature of alleles in the population and not to the segregation of genetic variations. Finally, as one of the evolutionary consequences of AM, long-term spousal resemblance provided an increasing trend for correlation between spouses in terms of their lipid serum level and obesity-related traits.http://www.sciencedirect.com/science/article/pii/S2405844025007819Assortative matingPolygenic risk scoresGenetic AMGWASSpousal resemblanceTCGS |
| spellingShingle | Parisa Riahi Amir Hossein Saeidian Albert Tenesa Carolyn T. Hogan Michael March Kamran Guity Mahmoud Amiri Roudbar Asieh Zahedi Maryam Zarkesh Farideh Neshati Mehdi Hedayati Fereidoun Azizi Hakon Hakonarson Maryam S. Daneshpour Mahdi Akbarzadeh Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) Heliyon Assortative mating Polygenic risk scores Genetic AM GWAS Spousal resemblance TCGS |
| title | Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) |
| title_full | Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) |
| title_fullStr | Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) |
| title_full_unstemmed | Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) |
| title_short | Genetic and environmental contribution to phenotypic resemblance between Iranian couples: Tehran Cardiometabolic and Genetic Study (TCGS) |
| title_sort | genetic and environmental contribution to phenotypic resemblance between iranian couples tehran cardiometabolic and genetic study tcgs |
| topic | Assortative mating Polygenic risk scores Genetic AM GWAS Spousal resemblance TCGS |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025007819 |
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