Association between the red blood cell distribution width-albumin ratio and cardiovascular diseases
BackgroundCardiovascular disease (CVD) is the major cause of death globally, ranking first in terms of morbidity and mortality among non-communicable diseases. Red blood cell distribution width (RDW) and albumin (ALB) possess potential clinical application values. Moreover, the ratio of the two, nam...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1529533/full |
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| author | Yan Liu Shougang Sun Ling Liu |
| author_facet | Yan Liu Shougang Sun Ling Liu |
| author_sort | Yan Liu |
| collection | DOAJ |
| description | BackgroundCardiovascular disease (CVD) is the major cause of death globally, ranking first in terms of morbidity and mortality among non-communicable diseases. Red blood cell distribution width (RDW) and albumin (ALB) possess potential clinical application values. Moreover, the ratio of the two, namely RAR, might hold more advantages in disease diagnosis. However, the relationship between RAR and CVD in the general population has not been studied yet.MethodThis represents a study encompassing 12,765 subjects. Logistic regression, Cox regression, restricted cubic splines, mediation analysis, and receiver operating characteristic curves were utilized to probe into the association between RAR and CVD, cardiovascular mortality rate and all—cause mortality rate.ResultA total of 12,765 participants were enrolled in this study, The mean age was 47.47 ± 16.33 years. Logistic regression revealed that RAR was positively correlated with the CVD. Furthermore, COX regression also illustrated that RAR was non—linearly and positively associated with both all—cause mortality rate and cardiovascular mortality rate (all—cause mortality: p−non−linear = 0.0322; cardiovascular mortality: p−non−linear = 0.0280). Additionally, the ROC results indicated that at various time points, RAR exhibited a stronger discriminatory capacity for cardiovascular mortality rate compared to all—cause mortality rate. HbA1c partially mediated the relationship between RAR and CVD. Subgroup analysis and interaction findings demonstrated that hypertension and race exerted a significant influence on the relationship between RAR and both all—cause mortality rate and cardiovascular mortality rate.ConclusionRAR was significantly linked to an elevated risk of CVD. The higher the RAR level, the greater the cardiovascular mortality rate and all—cause mortality rate. Thus, RAR could potentially be an independent risk factor for CVD. This underscores the crucial value of RAR in the discrimination and management of CVD. |
| format | Article |
| id | doaj-art-6a3fa6b092c041b0861263e44b006a8f |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-6a3fa6b092c041b0861263e44b006a8f2025-08-20T02:16:29ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-04-011210.3389/fcvm.2025.15295331529533Association between the red blood cell distribution width-albumin ratio and cardiovascular diseasesYan Liu0Shougang Sun1Ling Liu2The Second Clinical Medical School, The Second Hospital of Lanzhou University, Lanzhou, ChinaDepartment of Cardiology, The Second Hospital of Lanzhou University, Lanzhou, ChinaNursing Department, Chongqing Rongchang Hospital of Traditional Chinese Medicine, Chongqing, ChinaBackgroundCardiovascular disease (CVD) is the major cause of death globally, ranking first in terms of morbidity and mortality among non-communicable diseases. Red blood cell distribution width (RDW) and albumin (ALB) possess potential clinical application values. Moreover, the ratio of the two, namely RAR, might hold more advantages in disease diagnosis. However, the relationship between RAR and CVD in the general population has not been studied yet.MethodThis represents a study encompassing 12,765 subjects. Logistic regression, Cox regression, restricted cubic splines, mediation analysis, and receiver operating characteristic curves were utilized to probe into the association between RAR and CVD, cardiovascular mortality rate and all—cause mortality rate.ResultA total of 12,765 participants were enrolled in this study, The mean age was 47.47 ± 16.33 years. Logistic regression revealed that RAR was positively correlated with the CVD. Furthermore, COX regression also illustrated that RAR was non—linearly and positively associated with both all—cause mortality rate and cardiovascular mortality rate (all—cause mortality: p−non−linear = 0.0322; cardiovascular mortality: p−non−linear = 0.0280). Additionally, the ROC results indicated that at various time points, RAR exhibited a stronger discriminatory capacity for cardiovascular mortality rate compared to all—cause mortality rate. HbA1c partially mediated the relationship between RAR and CVD. Subgroup analysis and interaction findings demonstrated that hypertension and race exerted a significant influence on the relationship between RAR and both all—cause mortality rate and cardiovascular mortality rate.ConclusionRAR was significantly linked to an elevated risk of CVD. The higher the RAR level, the greater the cardiovascular mortality rate and all—cause mortality rate. Thus, RAR could potentially be an independent risk factor for CVD. This underscores the crucial value of RAR in the discrimination and management of CVD.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1529533/fullthe red blood cell distribution width-to-albumin ratiocardiovascular diseasesall -cause mortality rateall-cause mortality rateinflammation |
| spellingShingle | Yan Liu Shougang Sun Ling Liu Association between the red blood cell distribution width-albumin ratio and cardiovascular diseases Frontiers in Cardiovascular Medicine the red blood cell distribution width-to-albumin ratio cardiovascular diseases all -cause mortality rate all-cause mortality rate inflammation |
| title | Association between the red blood cell distribution width-albumin ratio and cardiovascular diseases |
| title_full | Association between the red blood cell distribution width-albumin ratio and cardiovascular diseases |
| title_fullStr | Association between the red blood cell distribution width-albumin ratio and cardiovascular diseases |
| title_full_unstemmed | Association between the red blood cell distribution width-albumin ratio and cardiovascular diseases |
| title_short | Association between the red blood cell distribution width-albumin ratio and cardiovascular diseases |
| title_sort | association between the red blood cell distribution width albumin ratio and cardiovascular diseases |
| topic | the red blood cell distribution width-to-albumin ratio cardiovascular diseases all -cause mortality rate all-cause mortality rate inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1529533/full |
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