Identification of plasma tRNA-derived small RNA i-tRF-15:31-Lys-CTT-1 as a biomarker for diagnosis and prognosis of pulmonary arterial hypertension

Identification of plasma tRNA-derived small RNA i-tRF-15:31-Lys-CTT-1 as a biomarker for diagnosis and prognosis of pulmonary arterial hypertension

Introduction: tRNA-derived small RNAs (tsRNAs) are emerging as noninvasive biomarkers of cellular damage. However, their role in pulmonary arterial hypertension (PAH) remains unclear. Methods: Plasma i-tRF-15:31-Lys-CTT-1 levels were quantified in a discovery cohort (n = 141 PAH patients; n = 50 con...

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Bibliographic Details
Main Authors: Yusi Chen, Tengteng Zhu, Fang Li, Yingjie Tan, Tianyu Wang, Xiaoqin Luo, Jun Luo, Yi Tang, Jianqiang Peng, Jiang Li
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-12-01
Series:Non-coding RNA Research
Subjects:
Pulmonary arterial hypertension
tRNA-derived small RNA
Diagnosis
Prognosis
Risk assessment
Online Access:http://www.sciencedirect.com/science/article/pii/S2468054025000903
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