Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease

Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease

ObjectiveTo investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients and explore the mediating role of cognitive function over time.MethodsData from 892 PD patients from the Parkinson’s Progression Markers Initiative (PPM...

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Bibliographic Details
Main Authors: Yue Xu, Durong Chen, Meiqi Dong, Yun Zhang, Hongmei Yu, Yanqing Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
depression
cognitive function
activities of daily living
cross-lagged panel model
longitudinal mediation analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1513373/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1513373/full

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