Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease
ObjectiveTo investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients and explore the mediating role of cognitive function over time.MethodsData from 892 PD patients from the Parkinson’s Progression Markers Initiative (PPM...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1513373/full |
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| author | Yue Xu Yue Xu Durong Chen Meiqi Dong Yun Zhang Yun Zhang Hongmei Yu Hongmei Yu Hongmei Yu Yanqing Han Yanqing Han Yanqing Han |
| author_facet | Yue Xu Yue Xu Durong Chen Meiqi Dong Yun Zhang Yun Zhang Hongmei Yu Hongmei Yu Hongmei Yu Yanqing Han Yanqing Han Yanqing Han |
| author_sort | Yue Xu |
| collection | DOAJ |
| description | ObjectiveTo investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients and explore the mediating role of cognitive function over time.MethodsData from 892 PD patients from the Parkinson’s Progression Markers Initiative (PPMI) database were included in this study, and depression, cognitive function, and ADL were measured using the Geriatric Depression Scale (GDS-15), Montreal Cognitive Assessment Scale (MoCA), and Unified Parkinson’s Disease Rating Scale, Part II (UPDRS II) respectively. The cross-lagged panel model (CLPM) was employed to analyze the reciprocal relationship between depression and ADL. Then, we explored the mediating role of cognitive function in the bidirectional relationship between depression and ADL in patients with PD, and the mediation effect test was carried out using a bias-corrected nonparametric percentile bootstrap approach.ResultsDepression in patients with PD predicted their subsequent ADL (β = 0.079, p < 0.01), and ADL also predicted their subsequent depression (β = 0.069, p < 0.05), In addition, Bootstrap analysis showed that cognitive function played a significant mediating role in prediction of depression to ADL in patients with PD (β = 0.006, p = 0.074, 95%CI = 0.001 ~ 0.014), and cognitive function also played a significant mediating role in prediction of depression to ADL (β = 0.006, p = 0.067, 95%CI = 0.001 ~ 0.013).ConclusionThere is a bidirectional relationship between depression and ADL in patients with PD. Furthermore, we found that cognitive function mediates the relationship that exists between depression and ADL in patients with PD. Interventions aimed at enhancing cognitive function could potentially lessen the vicious cycle of depression and ADL in PD, thus improving patient quality of life (QOL). |
| format | Article |
| id | doaj-art-6a34106126364e2f9d270ab92105118e |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-6a34106126364e2f9d270ab92105118e2025-02-12T07:25:39ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-02-011710.3389/fnagi.2025.15133731513373Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s diseaseYue Xu0Yue Xu1Durong Chen2Meiqi Dong3Yun Zhang4Yun Zhang5Hongmei Yu6Hongmei Yu7Hongmei Yu8Yanqing Han9Yanqing Han10Yanqing Han11Department of Neurology, Shanxi Cardiovascular Hospital, Taiyuan, ChinaDepartment of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, ChinaDepartment of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, ChinaDepartment of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, ChinaDepartment of Neurology, Shanxi Cardiovascular Hospital, Taiyuan, ChinaDepartment of Neurology, Cardiovascular Hospital Affiliated to Shanxi Medical University, Taiyuan, ChinaDepartment of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, ChinaShanxi Provincial Key Laboratory of Major Diseases Risk Assessment, Shanxi Medical University, Taiyuan, ChinaMOE Key Laboratory of Coal Environmental Pathogebicity and Prevention, Shanxi Medical University, Taiyuan, ChinaDepartment of Neurology, Shanxi Cardiovascular Hospital, Taiyuan, ChinaDepartment of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, ChinaDepartment of Neurology, Cardiovascular Hospital Affiliated to Shanxi Medical University, Taiyuan, ChinaObjectiveTo investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients and explore the mediating role of cognitive function over time.MethodsData from 892 PD patients from the Parkinson’s Progression Markers Initiative (PPMI) database were included in this study, and depression, cognitive function, and ADL were measured using the Geriatric Depression Scale (GDS-15), Montreal Cognitive Assessment Scale (MoCA), and Unified Parkinson’s Disease Rating Scale, Part II (UPDRS II) respectively. The cross-lagged panel model (CLPM) was employed to analyze the reciprocal relationship between depression and ADL. Then, we explored the mediating role of cognitive function in the bidirectional relationship between depression and ADL in patients with PD, and the mediation effect test was carried out using a bias-corrected nonparametric percentile bootstrap approach.ResultsDepression in patients with PD predicted their subsequent ADL (β = 0.079, p < 0.01), and ADL also predicted their subsequent depression (β = 0.069, p < 0.05), In addition, Bootstrap analysis showed that cognitive function played a significant mediating role in prediction of depression to ADL in patients with PD (β = 0.006, p = 0.074, 95%CI = 0.001 ~ 0.014), and cognitive function also played a significant mediating role in prediction of depression to ADL (β = 0.006, p = 0.067, 95%CI = 0.001 ~ 0.013).ConclusionThere is a bidirectional relationship between depression and ADL in patients with PD. Furthermore, we found that cognitive function mediates the relationship that exists between depression and ADL in patients with PD. Interventions aimed at enhancing cognitive function could potentially lessen the vicious cycle of depression and ADL in PD, thus improving patient quality of life (QOL).https://www.frontiersin.org/articles/10.3389/fnagi.2025.1513373/fullParkinson’s diseasedepressioncognitive functionactivities of daily livingcross-lagged panel modellongitudinal mediation analysis |
| spellingShingle | Yue Xu Yue Xu Durong Chen Meiqi Dong Yun Zhang Yun Zhang Hongmei Yu Hongmei Yu Hongmei Yu Yanqing Han Yanqing Han Yanqing Han Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease Frontiers in Aging Neuroscience Parkinson’s disease depression cognitive function activities of daily living cross-lagged panel model longitudinal mediation analysis |
| title | Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease |
| title_full | Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease |
| title_fullStr | Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease |
| title_full_unstemmed | Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease |
| title_short | Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease |
| title_sort | bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with parkinson s disease |
| topic | Parkinson’s disease depression cognitive function activities of daily living cross-lagged panel model longitudinal mediation analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1513373/full |
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