Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC

Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC

BackgroundHepatocellular carcinoma (HCC) is one of the most prevalent causes of cancer-related morbidity and mortality worldwide. Late-stage detection and the complex molecular mechanisms driving tumor progression contribute significantly to its poor prognosis. Dysregulated R-loops, three-stranded n...

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Bibliographic Details
Main Authors: Long Chen, Houzhi Yang, Xianfu Wei, Jianchao Liu, Xiuxin Han, Chao Zhang, Yongheng Liu, Yan Zhang, Yao Xu, Yiqin Li, Guowen Wang, Jinyan Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
R-loop
single-cell RNA-sequencing
HCC
tumor immune microenvironment
lipid metabolism reprogram
CLTC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1487372/full
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