Enhanced Immunogenicity of Chicken H9N2 Influenza Inactivated Vaccine Through a Novel Dual-Targeting Fusion Protein Strategy

Enhanced Immunogenicity of Chicken H9N2 Influenza Inactivated Vaccine Through a Novel Dual-Targeting Fusion Protein Strategy

Background/Objectives: Targeted delivery of antigens to dendritic cells (DCs) is an effective strategy for enhancing vaccine efficacy. Methods: In this study, dual-targeting fusion proteins (GRFT-VHH54 and GRFT-VHH74) were constructed by fusing Griffithsin (GRFT), an algae-derived lectin with envelo...

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Bibliographic Details
Main Authors: Hai Xu, Bihua Deng, Erzhong Wu, Yalu Zhu, Qiurong Qi, Yaming Feng, Yu Lu
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Vaccines
Subjects:
dual targeting
avian influenza
dendritic cell
envelope virus
Online Access:https://www.mdpi.com/2076-393X/13/3/294
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