Mechanism and application prospect of magnesium-based materials in cancer treatment
Magnesium-based materials, including magnesium alloys, have emerged as a promising class of biodegradable materials with potential applications in cancer therapy due to their unique properties, including biocompatibility, biodegradability, and the ability to modulate the tumor microenvironment. The...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Journal of Magnesium and Alloys |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956725000441 |
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| author | Yutong Ma Yi Wang Siwei Song Xinyue Yu Can Xu Long Wan Fan Yao Ke Yang Frank Witte Shude Yang |
| author_facet | Yutong Ma Yi Wang Siwei Song Xinyue Yu Can Xu Long Wan Fan Yao Ke Yang Frank Witte Shude Yang |
| author_sort | Yutong Ma |
| collection | DOAJ |
| description | Magnesium-based materials, including magnesium alloys, have emerged as a promising class of biodegradable materials with potential applications in cancer therapy due to their unique properties, including biocompatibility, biodegradability, and the ability to modulate the tumor microenvironment. The main degradation products of magnesium alloys are magnesium ions (Mg2+), hydrogen (H2), and magnesium hydroxide (Mg(OH)2). Magnesium ions can regulate tumor growth and metastasis by mediating the inflammatory response and oxidative stress, maintaining genomic stability, and affecting the tumor microenvironment. Similarly, hydrogen can inhibit tumorigenesis through antioxidant and anti-inflammatory properties. Moreover, Mg(OH)2 can alter the pH of the microenvironment, impacting tumorigenesis. Biodegradable magnesium alloys serve various functions in clinical applications, including, but not limited to, bone fixation, coronary stents, and drug carriers. Nonetheless, the anti-tumor mechanism associated with magnesium-based materials has not been thoroughly investigated. This review provides a comprehensive overview of the current state of magnesium-based therapies for cancer. It highlights the mechanisms of action, identifies the challenges that must be addressed, and discusses prospects for oncological applications. |
| format | Article |
| id | doaj-art-6a2a6abf85b04e95ae8b0d9a07cc01a6 |
| institution | DOAJ |
| issn | 2213-9567 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj-art-6a2a6abf85b04e95ae8b0d9a07cc01a62025-08-20T03:17:51ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672025-03-01133982101110.1016/j.jma.2025.02.010Mechanism and application prospect of magnesium-based materials in cancer treatmentYutong Ma0Yi Wang1Siwei Song2Xinyue Yu3Can Xu4Long Wan5Fan Yao6Ke Yang7Frank Witte8Shude Yang9Department of Breast Surgery, The First Hospital of China Medical University, Shenyang 110001, ChinaThe First Clinical College of China Medical University, Shenyang 110001, ChinaThe Second Clinical College of China Medical University, Shenyang 110001, ChinaThe Second Clinical College of China Medical University, Shenyang 110001, ChinaThe Second Clinical College of China Medical University, Shenyang 110001, ChinaDepartment of Pharmacy, The First Hospital of China Medical University, Shenyang 110001, Liaoning ChinaDepartment of Breast Surgery, The First Hospital of China Medical University, Shenyang 110001, China; Corresponding authors.Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China; Corresponding authors.Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité Medical University, 14197 Berlin, Germany; Corresponding authors.Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang 110011, China; Corresponding authors.Magnesium-based materials, including magnesium alloys, have emerged as a promising class of biodegradable materials with potential applications in cancer therapy due to their unique properties, including biocompatibility, biodegradability, and the ability to modulate the tumor microenvironment. The main degradation products of magnesium alloys are magnesium ions (Mg2+), hydrogen (H2), and magnesium hydroxide (Mg(OH)2). Magnesium ions can regulate tumor growth and metastasis by mediating the inflammatory response and oxidative stress, maintaining genomic stability, and affecting the tumor microenvironment. Similarly, hydrogen can inhibit tumorigenesis through antioxidant and anti-inflammatory properties. Moreover, Mg(OH)2 can alter the pH of the microenvironment, impacting tumorigenesis. Biodegradable magnesium alloys serve various functions in clinical applications, including, but not limited to, bone fixation, coronary stents, and drug carriers. Nonetheless, the anti-tumor mechanism associated with magnesium-based materials has not been thoroughly investigated. This review provides a comprehensive overview of the current state of magnesium-based therapies for cancer. It highlights the mechanisms of action, identifies the challenges that must be addressed, and discusses prospects for oncological applications.http://www.sciencedirect.com/science/article/pii/S2213956725000441Cancer therapyMagnesium based materialsMagnesium ionsHydrogen gasMg(OH)2Anti-tumor mechanism |
| spellingShingle | Yutong Ma Yi Wang Siwei Song Xinyue Yu Can Xu Long Wan Fan Yao Ke Yang Frank Witte Shude Yang Mechanism and application prospect of magnesium-based materials in cancer treatment Journal of Magnesium and Alloys Cancer therapy Magnesium based materials Magnesium ions Hydrogen gas Mg(OH)2 Anti-tumor mechanism |
| title | Mechanism and application prospect of magnesium-based materials in cancer treatment |
| title_full | Mechanism and application prospect of magnesium-based materials in cancer treatment |
| title_fullStr | Mechanism and application prospect of magnesium-based materials in cancer treatment |
| title_full_unstemmed | Mechanism and application prospect of magnesium-based materials in cancer treatment |
| title_short | Mechanism and application prospect of magnesium-based materials in cancer treatment |
| title_sort | mechanism and application prospect of magnesium based materials in cancer treatment |
| topic | Cancer therapy Magnesium based materials Magnesium ions Hydrogen gas Mg(OH)2 Anti-tumor mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2213956725000441 |
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