Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation
Complex microbial interactions occur on the surfaces within the oral cavity, where biofilms form highly organized ecosystems composed of diverse microbial communities and their metabolic products. These biofilms, typically located on the tooth surface or within the gingival sulcus, play a crucial ro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1602962/full |
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| author | Chengyuan Lv Ziyi Wang Ziyi Wang Ziyi Wang Zehui Li Xialing Shi Mingming Xiao Yan Xu |
| author_facet | Chengyuan Lv Ziyi Wang Ziyi Wang Ziyi Wang Zehui Li Xialing Shi Mingming Xiao Yan Xu |
| author_sort | Chengyuan Lv |
| collection | DOAJ |
| description | Complex microbial interactions occur on the surfaces within the oral cavity, where biofilms form highly organized ecosystems composed of diverse microbial communities and their metabolic products. These biofilms, typically located on the tooth surface or within the gingival sulcus, play a crucial role in both oral and systemic health. Recent studies have significantly improved our understanding of the mechanisms of biofilm formation, their structural characteristics, and their persistence over time. However, the intricate interactions between biofilms and the host, as well as their contributions to both local (e.g., dental caries and periodontitis) and systemic conditions, remain only partially understood. This mini-review summarizes recent scientific progress on the formation, structural dynamics, and ecological functions of oral biofilms. It also highlights emerging strategies for modulating biofilm composition and activity, the regulatory systems governing these interactions, and potential directions for microbiome-based therapies in future research. |
| format | Article |
| id | doaj-art-6a281e6d8e2844178d80b3aa19a8d8b1 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-6a281e6d8e2844178d80b3aa19a8d8b12025-08-20T03:28:43ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-07-011610.3389/fmicb.2025.16029621602962Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulationChengyuan Lv0Ziyi Wang1Ziyi Wang2Ziyi Wang3Zehui Li4Xialing Shi5Mingming Xiao6Yan Xu7Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, ChinaDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, ChinaDepartment of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Thoracic Surgery, First Hospital of China Medical University, Shenyang, ChinaDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, ChinaDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, ChinaDepartment of Pathology, The People’s Hospital of Liaoning Province, Shenyang, ChinaDepartment of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, ChinaComplex microbial interactions occur on the surfaces within the oral cavity, where biofilms form highly organized ecosystems composed of diverse microbial communities and their metabolic products. These biofilms, typically located on the tooth surface or within the gingival sulcus, play a crucial role in both oral and systemic health. Recent studies have significantly improved our understanding of the mechanisms of biofilm formation, their structural characteristics, and their persistence over time. However, the intricate interactions between biofilms and the host, as well as their contributions to both local (e.g., dental caries and periodontitis) and systemic conditions, remain only partially understood. This mini-review summarizes recent scientific progress on the formation, structural dynamics, and ecological functions of oral biofilms. It also highlights emerging strategies for modulating biofilm composition and activity, the regulatory systems governing these interactions, and potential directions for microbiome-based therapies in future research.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1602962/fulloral biofilmoral diseasemicrobiomecolonystructurepersistence |
| spellingShingle | Chengyuan Lv Ziyi Wang Ziyi Wang Ziyi Wang Zehui Li Xialing Shi Mingming Xiao Yan Xu Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation Frontiers in Microbiology oral biofilm oral disease microbiome colony structure persistence |
| title | Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation |
| title_full | Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation |
| title_fullStr | Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation |
| title_full_unstemmed | Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation |
| title_short | Formation, architecture, and persistence of oral biofilms: recent scientific discoveries and new strategies for their regulation |
| title_sort | formation architecture and persistence of oral biofilms recent scientific discoveries and new strategies for their regulation |
| topic | oral biofilm oral disease microbiome colony structure persistence |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1602962/full |
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