Nasal Delivery of Asiatic Acid Ameliorates Scopolamine-Induced Memory Dysfunction in Mice
Asiatic acid (AA) has previously shown its neuroprotective effects, but low oral bioavailability limits its penetration into the brain. This study aimed to investigate the effect of intranasal AA administration in mice with memory dysfunction induced by scopolamine. Mice received either intranasal A...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2024/9941034 |
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| author | Su Lwin Lwin Myint Ratchanee Rodsiri Hattaya Benya-Aphikul Tissana Rojanaratha Garnpimol Ritthidej Ridho Islamie |
| author_facet | Su Lwin Lwin Myint Ratchanee Rodsiri Hattaya Benya-Aphikul Tissana Rojanaratha Garnpimol Ritthidej Ridho Islamie |
| author_sort | Su Lwin Lwin Myint |
| collection | DOAJ |
| description | Asiatic acid (AA) has previously shown its neuroprotective effects, but low oral bioavailability limits its penetration into the brain. This study aimed to investigate the effect of intranasal AA administration in mice with memory dysfunction induced by scopolamine. Mice received either intranasal AA (INAA), oral AA (POAA3 or POAA30), or donepezil, followed by scopolamine for 10 days. Morris water maze (MWM) was performed on days 0–5, 30 min after treatment. Locomotor activity was conducted on day 6 followed by brain collection. In MWM, INAA treatment had significantly reduced escape latency on days 2–4, while POAA3 decreased escape latency on day 3 and POAA30 and donepezil decreased escape latency on day 4. INAA inhibited acetylcholinesterase activity, increased catalase protein expression, and decreased malondialdehyde levels in the brain tissue. Therefore, intranasal administration of AA produced a rapid onset in the protection of learning and memory deficits induced by scopolamine through acetylcholinesterase inhibition and antioxidant effect. |
| format | Article |
| id | doaj-art-6a27f14bb3734eb5b1e02e486355d53c |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-6a27f14bb3734eb5b1e02e486355d53c2025-02-03T11:56:02ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902024-01-01202410.1155/2024/9941034Nasal Delivery of Asiatic Acid Ameliorates Scopolamine-Induced Memory Dysfunction in MiceSu Lwin Lwin Myint0Ratchanee Rodsiri1Hattaya Benya-Aphikul2Tissana Rojanaratha3Garnpimol Ritthidej4Ridho Islamie5Department of Pharmacology and PhysiologyDepartment of Pharmacology and PhysiologyDepartment of Pharmacology and PhysiologyDepartment of Pharmaceutics and Industrial PharmacyDepartment of Pharmaceutics and Industrial PharmacyDepartment of Pharmacology and PhysiologyAsiatic acid (AA) has previously shown its neuroprotective effects, but low oral bioavailability limits its penetration into the brain. This study aimed to investigate the effect of intranasal AA administration in mice with memory dysfunction induced by scopolamine. Mice received either intranasal AA (INAA), oral AA (POAA3 or POAA30), or donepezil, followed by scopolamine for 10 days. Morris water maze (MWM) was performed on days 0–5, 30 min after treatment. Locomotor activity was conducted on day 6 followed by brain collection. In MWM, INAA treatment had significantly reduced escape latency on days 2–4, while POAA3 decreased escape latency on day 3 and POAA30 and donepezil decreased escape latency on day 4. INAA inhibited acetylcholinesterase activity, increased catalase protein expression, and decreased malondialdehyde levels in the brain tissue. Therefore, intranasal administration of AA produced a rapid onset in the protection of learning and memory deficits induced by scopolamine through acetylcholinesterase inhibition and antioxidant effect.http://dx.doi.org/10.1155/2024/9941034 |
| spellingShingle | Su Lwin Lwin Myint Ratchanee Rodsiri Hattaya Benya-Aphikul Tissana Rojanaratha Garnpimol Ritthidej Ridho Islamie Nasal Delivery of Asiatic Acid Ameliorates Scopolamine-Induced Memory Dysfunction in Mice Advances in Pharmacological and Pharmaceutical Sciences |
| title | Nasal Delivery of Asiatic Acid Ameliorates Scopolamine-Induced Memory Dysfunction in Mice |
| title_full | Nasal Delivery of Asiatic Acid Ameliorates Scopolamine-Induced Memory Dysfunction in Mice |
| title_fullStr | Nasal Delivery of Asiatic Acid Ameliorates Scopolamine-Induced Memory Dysfunction in Mice |
| title_full_unstemmed | Nasal Delivery of Asiatic Acid Ameliorates Scopolamine-Induced Memory Dysfunction in Mice |
| title_short | Nasal Delivery of Asiatic Acid Ameliorates Scopolamine-Induced Memory Dysfunction in Mice |
| title_sort | nasal delivery of asiatic acid ameliorates scopolamine induced memory dysfunction in mice |
| url | http://dx.doi.org/10.1155/2024/9941034 |
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