To cleave or not and how? The DNA exonucleases and endonucleases in immunity
DNA exonucleases and endonucleases are key executors of the genome during many physiological processes. They generate double-stranded DNA by cleaving damaged endogenous or exogenous DNA, triggering the activation of the innate immune pathways such as cGAS-STING-IFN, and enabling the body to produce...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304224000163 |
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| author | Mingjun Lu Jinghong Wu Qing Gao Renjing Jin Changming An Teng Ma |
| author_facet | Mingjun Lu Jinghong Wu Qing Gao Renjing Jin Changming An Teng Ma |
| author_sort | Mingjun Lu |
| collection | DOAJ |
| description | DNA exonucleases and endonucleases are key executors of the genome during many physiological processes. They generate double-stranded DNA by cleaving damaged endogenous or exogenous DNA, triggering the activation of the innate immune pathways such as cGAS-STING-IFN, and enabling the body to produce anti-viral or anti-tumor immune responses. This is of great significance for maintaining the stability of the genome and improving the therapeutic efficacy of tumors. In addition, genomic instability caused by exonuclease mutations contributes to the development of various autoimmune diseases. This review summarizes the DNA exonucleases and endonucleases which have critical functions in immunity and associated diseases. |
| format | Article |
| id | doaj-art-6a270bd551cd4e9e94a6f24922f1178b |
| institution | OA Journals |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-6a270bd551cd4e9e94a6f24922f1178b2025-08-20T02:35:29ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-03-0112210121910.1016/j.gendis.2024.101219To cleave or not and how? The DNA exonucleases and endonucleases in immunityMingjun Lu0Jinghong Wu1Qing Gao2Renjing Jin3Changming An4Teng Ma5Cancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaCancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaCancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaCancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, ChinaDepartment of Head and Neck Surgery, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China; Corresponding author.Cancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Corresponding author.DNA exonucleases and endonucleases are key executors of the genome during many physiological processes. They generate double-stranded DNA by cleaving damaged endogenous or exogenous DNA, triggering the activation of the innate immune pathways such as cGAS-STING-IFN, and enabling the body to produce anti-viral or anti-tumor immune responses. This is of great significance for maintaining the stability of the genome and improving the therapeutic efficacy of tumors. In addition, genomic instability caused by exonuclease mutations contributes to the development of various autoimmune diseases. This review summarizes the DNA exonucleases and endonucleases which have critical functions in immunity and associated diseases.http://www.sciencedirect.com/science/article/pii/S2352304224000163cGAS-STING pathwayDNA repairEndonucleasesExonucleasesImmunity |
| spellingShingle | Mingjun Lu Jinghong Wu Qing Gao Renjing Jin Changming An Teng Ma To cleave or not and how? The DNA exonucleases and endonucleases in immunity Genes and Diseases cGAS-STING pathway DNA repair Endonucleases Exonucleases Immunity |
| title | To cleave or not and how? The DNA exonucleases and endonucleases in immunity |
| title_full | To cleave or not and how? The DNA exonucleases and endonucleases in immunity |
| title_fullStr | To cleave or not and how? The DNA exonucleases and endonucleases in immunity |
| title_full_unstemmed | To cleave or not and how? The DNA exonucleases and endonucleases in immunity |
| title_short | To cleave or not and how? The DNA exonucleases and endonucleases in immunity |
| title_sort | to cleave or not and how the dna exonucleases and endonucleases in immunity |
| topic | cGAS-STING pathway DNA repair Endonucleases Exonucleases Immunity |
| url | http://www.sciencedirect.com/science/article/pii/S2352304224000163 |
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